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Protein

Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Gene

Coq3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.UniRule annotation
S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei124S-adenosyl-L-methionineUniRule annotation1
Binding sitei154S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei175S-adenosyl-L-methionineUniRule annotation1
Binding sitei222S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • glycerol metabolic process Source: Ensembl
  • methylation Source: RGD
  • regulation of ubiquinone biosynthetic process Source: RGD
  • ubiquinone biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13874
BRENDAi2.1.1.114 5301
2.1.1.222 5301
2.1.1.64 5301
ReactomeiR-RNO-2142789 Ubiquinol biosynthesis
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferase, mitochondrialUniRule annotation
Alternative name(s):
3-demethylubiquinol 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Polyprenyldihydroxybenzoate methyltransferaseUniRule annotation (EC:2.1.1.114UniRule annotation)
Gene namesi
Name:Coq3UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2380 Coq3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 86MitochondrionUniRule annotationAdd BLAST86
ChainiPRO_000003592887 – 345Ubiquinone biosynthesis O-methyltransferase, mitochondrialAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143N6-acetyllysineBy similarity1
Modified residuei149N6-acetyllysineBy similarity1
Modified residuei196N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ63159
PRIDEiQ63159

PTM databases

iPTMnetiQ63159
PhosphoSitePlusiQ63159

Expressioni

Gene expression databases

BgeeiENSRNOG00000009974
GenevisibleiQ63159 RN

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013384

Structurei

3D structure databases

ProteinModelPortaliQ63159
SMRiQ63159
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1270 Eukaryota
COG2227 LUCA
GeneTreeiENSGT00390000007284
HOGENOMiHOG000278064
HOVERGENiHBG051078
InParanoidiQ63159
KOiK00591
OMAiGTHDWEK
OrthoDBiEOG091G0ICD
PhylomeDBiQ63159

Family and domain databases

HAMAPiMF_00472 UbiG, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR010233 UbiG_MeTrfase
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01983 UbiG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRGGRLSSR GVRFLETLGF ACPSAVAEPP RVTSWTAFSG NQLTRNLQIK
60 70 80 90 100
PWEFSGHRTM WLRSYRITFS CLTRLKTYRS SWKKLYSTSQ TVDSKEVKTF
110 120 130 140 150
QALAHSWWDE QGKFAPLHSM NDLRVPFIRD NLLKTSTNHD PGKPLSGMKI
160 170 180 190 200
LDVGCGGGLL TEPLGRLGAS VVGIDPVAEN IKIAQHHKSF DPVLDKRIQY
210 220 230 240 250
RVCSLEETLN ENAECFDAVV ASEVVEHVNN LEMFIQCCYQ VLKPGGSLFI
260 270 280 290 300
TTVNKTQLSY VLGIVFSEQI AGIVPKGTHT WEKFVSPEKL ESILEPNGLS
310 320 330 340
VETVAGMVYN PFSGYWHWTE NTSLNYAAHA VRARAQEHLE PAESA
Length:345
Mass (Da):38,708
Last modified:January 4, 2005 - v2
Checksum:i68ABF28DF7E252AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081811 mRNA Translation: AAH81811.1
BC126094 mRNA Translation: AAI26095.1
L20427 mRNA Translation: AAC37643.1
PIRiI53714
RefSeqiNP_062060.1, NM_019187.1
XP_017448690.1, XM_017593201.1
UniGeneiRn.3824

Genome annotation databases

EnsembliENSRNOT00000013384; ENSRNOP00000013384; ENSRNOG00000009974
GeneIDi29309
KEGGirno:29309
UCSCiRGD:2380 rat

Similar proteinsi

Entry informationi

Entry nameiCOQ3_RAT
AccessioniPrimary (citable) accession number: Q63159
Secondary accession number(s): A0JN24, Q642D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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