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Protein

Ubiquinone biosynthesis O-methyltransferase, mitochondrial

Gene

Coq3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.UniRule annotation
S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei124 – 1241S-adenosyl-L-methionineUniRule annotation
Binding sitei154 – 1541S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei175 – 1751S-adenosyl-L-methionineUniRule annotation
Binding sitei222 – 2221S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • glycerol metabolic process Source: Ensembl
  • methylation Source: RGD
  • regulation of ubiquinone biosynthetic process Source: RGD
  • ubiquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13874.
BRENDAi2.1.1.114. 5301.
2.1.1.222. 5301.
2.1.1.64. 5301.
ReactomeiR-RNO-2142789. Ubiquinol biosynthesis.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferase, mitochondrialUniRule annotation
Alternative name(s):
3-demethylubiquinol 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Polyprenyldihydroxybenzoate methyltransferaseUniRule annotation (EC:2.1.1.114UniRule annotation)
Gene namesi
Name:Coq3UniRule annotation
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2380. Coq3.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: UniProtKB-HAMAP
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8686MitochondrionSequence analysisAdd
BLAST
Chaini87 – 345259Ubiquinone biosynthesis O-methyltransferase, mitochondrialPRO_0000035928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei143 – 1431N6-acetyllysineBy similarity
Modified residuei149 – 1491N6-acetyllysineBy similarity
Modified residuei196 – 1961N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ63159.
PRIDEiQ63159.

PTM databases

iPTMnetiQ63159.

Expressioni

Gene expression databases

GenevisibleiQ63159. RN.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013384.

Structurei

3D structure databases

ProteinModelPortaliQ63159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1270. Eukaryota.
COG2227. LUCA.
GeneTreeiENSGT00390000007284.
HOGENOMiHOG000278064.
HOVERGENiHBG051078.
InParanoidiQ63159.
KOiK00591.
OMAiHDWEKFV.
OrthoDBiEOG7FJH1X.
PhylomeDBiQ63159.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRGGRLSSR GVRFLETLGF ACPSAVAEPP RVTSWTAFSG NQLTRNLQIK
60 70 80 90 100
PWEFSGHRTM WLRSYRITFS CLTRLKTYRS SWKKLYSTSQ TVDSKEVKTF
110 120 130 140 150
QALAHSWWDE QGKFAPLHSM NDLRVPFIRD NLLKTSTNHD PGKPLSGMKI
160 170 180 190 200
LDVGCGGGLL TEPLGRLGAS VVGIDPVAEN IKIAQHHKSF DPVLDKRIQY
210 220 230 240 250
RVCSLEETLN ENAECFDAVV ASEVVEHVNN LEMFIQCCYQ VLKPGGSLFI
260 270 280 290 300
TTVNKTQLSY VLGIVFSEQI AGIVPKGTHT WEKFVSPEKL ESILEPNGLS
310 320 330 340
VETVAGMVYN PFSGYWHWTE NTSLNYAAHA VRARAQEHLE PAESA
Length:345
Mass (Da):38,708
Last modified:January 4, 2005 - v2
Checksum:i68ABF28DF7E252AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081811 mRNA. Translation: AAH81811.1.
BC126094 mRNA. Translation: AAI26095.1.
L20427 mRNA. Translation: AAC37643.1.
PIRiI53714.
RefSeqiNP_062060.1. NM_019187.1.
UniGeneiRn.3824.

Genome annotation databases

EnsembliENSRNOT00000013384; ENSRNOP00000013384; ENSRNOG00000009974.
GeneIDi29309.
KEGGirno:29309.
UCSCiRGD:2380. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC081811 mRNA. Translation: AAH81811.1.
BC126094 mRNA. Translation: AAI26095.1.
L20427 mRNA. Translation: AAC37643.1.
PIRiI53714.
RefSeqiNP_062060.1. NM_019187.1.
UniGeneiRn.3824.

3D structure databases

ProteinModelPortaliQ63159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013384.

PTM databases

iPTMnetiQ63159.

Proteomic databases

PaxDbiQ63159.
PRIDEiQ63159.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013384; ENSRNOP00000013384; ENSRNOG00000009974.
GeneIDi29309.
KEGGirno:29309.
UCSCiRGD:2380. rat.

Organism-specific databases

CTDi51805.
RGDi2380. Coq3.

Phylogenomic databases

eggNOGiKOG1270. Eukaryota.
COG2227. LUCA.
GeneTreeiENSGT00390000007284.
HOGENOMiHOG000278064.
HOVERGENiHBG051078.
InParanoidiQ63159.
KOiK00591.
OMAiHDWEKFV.
OrthoDBiEOG7FJH1X.
PhylomeDBiQ63159.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciMetaCyc:MONOMER-13874.
BRENDAi2.1.1.114. 5301.
2.1.1.222. 5301.
2.1.1.64. 5301.
ReactomeiR-RNO-2142789. Ubiquinol biosynthesis.

Miscellaneous databases

PROiQ63159.

Gene expression databases

GenevisibleiQ63159. RN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Heart.
  2. "Cloning of a rat cDNA encoding dihydroxypolyprenylbenzoate methyltransferase by functional complementation of a Saccharomyces cerevisiae mutant deficient in ubiquinone biosynthesis."
    Marbois B.N., Hsu A., Pillai R., Colicelli J., Clarke C.F.
    Gene 138:213-217(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-345.
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiCOQ3_RAT
AccessioniPrimary (citable) accession number: Q63159
Secondary accession number(s): A0JN24, Q642D7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 4, 2005
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.