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Protein
Submitted name:

Protein Sp4

Gene

Sp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: RGD
  • metal ion binding Source: InterPro
  • transcription coactivator activity Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Sp4Imported
Submitted name:
RCG21090Imported
Submitted name:
Zinc finger proteinImported
Gene namesi
Name:Sp4Imported
Synonyms:HF-1bImported
ORF Names:rCG_21090Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi3741. Sp4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • intercellular bridge Source: Ensembl
  • microtubule cytoskeleton Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007625.

Structurei

3D structure databases

SMRiQ63158. Positions 634-732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini646 – 67530C2H2-typeInterPro annotationAdd
BLAST
Domaini676 – 70530C2H2-typeInterPro annotationAdd
BLAST
Domaini706 – 73328C2H2-typeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
KOiK09194.
OMAiERTIEEP.
OrthoDBiEOG7JQBMX.
PhylomeDBiQ63158.
TreeFamiTF350150.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030453. SP4.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF17. PTHR23235:SF17. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63158-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQKKEEEE EAAAAMATEG GKTSEPENNN KKPKTSGSQD SQPSPLALLA
60 70 80 90 100
ATCSKIGTPG ENQATGQQQI IIDPSQGLVQ LQNQPQQLEL VTTQLAGNAW
110 120 130 140 150
QLVASTPPAS KENNVSQPAS SSSSSSSSNN GSSSPTKTKS GNPSTPNQFQ
160 170 180 190 200
VIQVQNPSGS VQYQVIPQLQ TVEGQQIQIN PTSSSSLQDL QGQIQLISAG
210 220 230 240 250
NNQAILTAAN RTASGNILAQ NLANQTVPVQ IRPGVSIPLQ LQTLPGTQAQ
260 270 280 290 300
VVTTLPINIG GVTLALPVIN NVTAGGGTGQ VGQPTTTTTD SGTSNGNQLV
310 320 330 340 350
STPTTSTAPA STMPESPSSS TTCTTTASTS LTSSDTLVSS ADTGQYASTS
360 370 380 390 400
ASSSERTIEE PQTPAATESE AQSSSQLQSN GIQNAQDQSN SLQQVQIVGQ
410 420 430 440 450
PILQQIQIQQ PQQQIIQAIP PQSFQLQSGQ TIQTIQQQPL QNVQLQAVNP
460 470 480 490 500
TQVLIRAPTL TPSGQISWQT VQVQNIQSLS NLQVQNAGLS QQLTITPVSS
510 520 530 540 550
SGGTTLAQIA PVAVAGAPIT LNTAQLASVP NLQTVSVANL GAAGVQVQGV
560 570 580 590 600
PVTITSVAGQ QQGQDGVKVQ QATIAPVTVA VGGIANATIG AVSPDQLTQV
610 620 630 640 650
HLQQGQQTSD AEVQPGKRLR RVACSCPNCR EGEGRGSSEP GKKKQHVCHI
660 670 680 690 700
EGCGKVYGKT SHLRAHLRWH TGERPFICNW MFCGKRFTRS DELQRHRRTH
710 720 730 740 750
TGEKRFECPE CSKRFMRSDH LSKHVKTHQN KKGGGTALAI VTSGELDSSV
760 770 780
TEVLGSPRIV TVAAISQDSN PATPNVSTNM EEF
Length:783
Mass (Da):81,984
Last modified:November 1, 1996 - v1
Checksum:i394AA6D4DEA5A197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07065921 Genomic DNA. No translation available.
U07610 mRNA. Translation: AAA17375.1.
CH474038 Genomic DNA. Translation: EDL89090.1.
PIRiA48143.
RefSeqiNP_036893.1. NM_012761.1.
UniGeneiRn.9989.

Genome annotation databases

EnsembliENSRNOT00000007625; ENSRNOP00000007625; ENSRNOG00000005472.
GeneIDi25162.
KEGGirno:25162.
UCSCiRGD:3741. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07065921 Genomic DNA. No translation available.
U07610 mRNA. Translation: AAA17375.1.
CH474038 Genomic DNA. Translation: EDL89090.1.
PIRiA48143.
RefSeqiNP_036893.1. NM_012761.1.
UniGeneiRn.9989.

3D structure databases

SMRiQ63158. Positions 634-732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007625; ENSRNOP00000007625; ENSRNOG00000005472.
GeneIDi25162.
KEGGirno:25162.
UCSCiRGD:3741. rat.

Organism-specific databases

CTDi6671.
RGDi3741. Sp4.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118984.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
KOiK09194.
OMAiERTIEEP.
OrthoDBiEOG7JQBMX.
PhylomeDBiQ63158.
TreeFamiTF350150.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR030450. Sp1_fam.
IPR030453. SP4.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR23235. PTHR23235. 1 hit.
PTHR23235:SF17. PTHR23235:SF17. 1 hit.
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene."
    Zhu H., Nguyen V.T.B., Brown A.B., Pourhosseini A., Garcia A.V., van Bilsen M., Chien K.R.
    Mol. Cell. Biol. 13:4432-4444(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: HeartImported.
  2. Zhu H.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: HeartImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiQ63158_RAT
AccessioniPrimary (citable) accession number: Q63158
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.