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Protein

Netrin receptor DCC

Gene

Dcc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity).By similarity1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • netrin receptor activity Source: RGD
  • transcription coactivator activity Source: RGD

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • axon guidance Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • response to amphetamine Source: RGD

Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-RNO-418890. Role of second messengers in netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor DCC
Alternative name(s):
Tumor suppressor protein DCC
Gene namesi
Name:Dcc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2492. Dcc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1100 – 1120HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • axon Source: RGD
  • growth cone membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1178S → A: Abolishes phosphorylation by MAPK1; when associated with A-1187 and A-1267. 1 Publication1
Mutagenesisi1187T → A: Abolishes phosphorylation by MAPK1; when associated with A-1178 and A-1267. 1 Publication1
Mutagenesisi1267S → A: Abolishes phosphorylation by MAPK1; when associated with A-1178 and A-1187. 1 Publication1

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000041624626 – 1445Netrin receptor DCCAdd BLAST1420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi61 ↔ 117PROSITE-ProRule annotation1 Publication
Glycosylationi94N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi161 ↔ 212PROSITE-ProRule annotation1 Publication
Disulfide bondi261 ↔ 310PROSITE-ProRule annotation1 Publication
Glycosylationi299N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi318N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi352 ↔ 400PROSITE-ProRule annotation1 Publication
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1178Phosphoserine; by MAPK11 Publication1
Modified residuei1187Phosphothreonine; by MAPK11 Publication1
Modified residuei1267Phosphoserine; by MAPK11 Publication1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ63155.
PRIDEiQ63155.

PTM databases

iPTMnetiQ63155.
PhosphoSitePlusiQ63155.
UniCarbKBiQ63155.

Expressioni

Tissue specificityi

Detected in embryonic spinal cord, predominantly in axons of commissural neurons (at protein level). Detected in embryonic spinal cord.1 Publication

Gene expression databases

BgeeiENSRNOG00000033099.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By similarity). Interacts with DSCAM. Interacts with PTK2/FAK1. Interacts with MYO10 (By similarity). Interacts with MAPK1. Interacts with NTN1. Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-46811N.
IntActiQ63155. 9 interactors.
STRINGi10116.ENSRNOP00000063072.

Structurei

Secondary structure

11445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 44Combined sources6
Beta strandi49 – 51Combined sources3
Beta strandi57 – 59Combined sources3
Beta strandi62 – 64Combined sources3
Beta strandi71 – 76Combined sources6
Beta strandi89 – 91Combined sources3
Beta strandi97 – 99Combined sources3
Beta strandi113 – 120Combined sources8
Helixi122 – 124Combined sources3
Beta strandi126 – 128Combined sources3
Beta strandi132 – 136Combined sources5
Beta strandi149 – 152Combined sources4
Beta strandi157 – 159Combined sources3
Beta strandi170 – 179Combined sources10
Beta strandi188 – 191Combined sources4
Beta strandi197 – 199Combined sources3
Helixi204 – 206Combined sources3
Beta strandi208 – 215Combined sources8
Beta strandi226 – 231Combined sources6
Beta strandi238 – 244Combined sources7
Beta strandi249 – 252Combined sources4
Beta strandi257 – 259Combined sources3
Beta strandi262 – 267Combined sources6
Beta strandi270 – 275Combined sources6
Beta strandi283 – 290Combined sources8
Turni291 – 293Combined sources3
Beta strandi294 – 297Combined sources4
Helixi302 – 304Combined sources3
Beta strandi306 – 314Combined sources9
Beta strandi317 – 335Combined sources19
Beta strandi348 – 350Combined sources3
Beta strandi353 – 358Combined sources6
Beta strandi361 – 366Combined sources6
Beta strandi374 – 380Combined sources7
Turni381 – 383Combined sources3
Beta strandi384 – 389Combined sources6
Helixi392 – 394Combined sources3
Beta strandi396 – 404Combined sources9
Beta strandi407 – 416Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LAFX-ray2.40A39-421[»]
3O71X-ray1.95B1140-1166[»]
ProteinModelPortaliQ63155.
SMRiQ63155.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63155.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 135Ig-like C2-type 1Add BLAST110
Domaini139 – 229Ig-like C2-type 2Add BLAST91
Domaini234 – 326Ig-like C2-type 3Add BLAST93
Domaini331 – 416Ig-like C2-type 4Add BLAST86
Domaini431 – 524Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini530 – 620Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini625 – 718Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini728 – 821Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini846 – 942Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST97
Domaini947 – 1044Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1252 – 1373Pro-richAdd BLAST122

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
HOGENOMiHOG000230686.
HOVERGENiHBG005455.
InParanoidiQ63155.
KOiK06765.
TreeFamiTF321506.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiView protein in InterPro
IPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
PANTHERiPTHR10489:SF898. PTHR10489:SF898. 1 hit.
PfamiView protein in Pfam
PF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 1 hit.
SMARTiView protein in SMART
SM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSLGCVWV PKLAFVLFGA SLLSAHLQVT GFQIKPFTSL HFVSEPSDAV
60 70 80 90 100
TMRGGNVLLN CSAESDRGVP VIKWKKDGLI LALGMDDRKQ QLPNGSLLIQ
110 120 130 140 150
NILHSRHHKP DEGLYQCEAS LGDSGSIISR TAKVMVAGPL RFLSQTESIT
160 170 180 190 200
AFMGDTVLLK CEVIGDPMPT IHWQKNQQDL NPIPGDSRVV VLPSGALQIS
210 220 230 240 250
RLQPGDSGVY RCSARNPAST RTGNEAEVRI LSDPGLHRQL YFLQRPSNVI
260 270 280 290 300
AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV
310 320 330 340 350
TDDDSGTYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF
360 370 380 390 400
ECAVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC
410 420 430 440 450
VAENEAGNAQ SSAQLIVPKP AIPSSSILPS APRDVVPVLV SSRFVRLSWR
460 470 480 490 500
PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF
510 520 530 540 550
RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLHAVSAS PTSILITWEP
560 570 580 590 600
PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYTLRFLA
610 620 630 640 650
YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT
710 720 730 740 750
VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSGPDV STPMLPPVGV
860 870 880 890 900
QAVALTHEAV RVSWADNSVP KNQKTSDVRL YTVRWRTSFS ASAKYKSEDT
910 920 930 940 950
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD
960 970 980 990 1000
LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI
1010 1020 1030 1040 1050
SGDRLTHQIM DLSLDTMYYF RIQARNAKGV GPLSDPILFR TLKVEHPDKM
1060 1070 1080 1090 1100
ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV
1110 1120 1130 1140 1150
ITVVTVGVLT VLVVVIVAVI CTRRSSAQQR KKRATHSASK RKGSQKDLRP
1160 1170 1180 1190 1200
PDLWIHHEEM EMKNIEKPAG TDPAGRGSPI QSCQDLTPVS HSQSESQMGS
1210 1220 1230 1240 1250
KSASHSGQDT EEAGSSMSTL ERSLAARRAT RTKLMIPMEA QSNNPAVVSA
1260 1270 1280 1290 1300
IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRTVS
1310 1320 1330 1340 1350
EGPTAQQQPM LPPAQPEHPS SEEAPSRTIP TACVRPTHPL RSFANPLLPP
1360 1370 1380 1390 1400
PMSAIEPKVP YTPLLSQPGP TLPKTHVKTA SLGLAGKARS PLLPVSVPTA
1410 1420 1430 1440
PEVSEESHKP TEDPASVYEQ DDLSEQMASL EGLMKQLNAI TGSAF
Length:1,445
Mass (Da):157,941
Last modified:January 1, 1998 - v2
Checksum:i084F625954481988
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68725 mRNA. Translation: AAB41099.1.
CH473971 Genomic DNA. Translation: EDM14792.1.
RefSeqiNP_036973.1. NM_012841.1.
UniGeneiRn.10666.

Genome annotation databases

GeneIDi25311.
KEGGirno:25311.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDCC_RAT
AccessioniPrimary (citable) accession number: Q63155
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: January 1, 1998
Last modified: May 10, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families