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Q63148

- CHRD_RAT

UniProt

Q63148 - CHRD_RAT

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Protein
Chordin
Gene
Chrd
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes By similarity.

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: Ensembl
  2. forebrain development Source: Ensembl
  3. gastrulation with mouth forming second Source: Ensembl
  4. mesoderm formation Source: Ensembl
  5. negative regulation of BMP signaling pathway Source: Ensembl
  6. negative regulation of cell migration Source: Ensembl
  7. negative regulation of osteoblast differentiation Source: Ensembl
  8. osteoblast differentiation Source: Ensembl
  9. positive regulation of cell adhesion Source: Ensembl
  10. positive regulation of mesenchymal cell proliferation Source: Ensembl
  11. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Gene namesi
Name:Chrd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi620181. Chrd.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 951925Chordin
PRO_0000219088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi880 – 8801N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63148.
PRIDEiQ63148.

Expressioni

Gene expression databases

GenevestigatoriQ63148.

Interactioni

Subunit structurei

Interacts with TWSG1 and/or BMP4 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002394.

Structurei

3D structure databases

ProteinModelPortaliQ63148.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12678VWFC 1
Add
BLAST
Domaini171 – 280110CHRD 1
Add
BLAST
Domaini282 – 401120CHRD 2
Add
BLAST
Domaini402 – 523122CHRD 3
Add
BLAST
Domaini529 – 649121CHRD 4
Add
BLAST
Domaini702 – 76261VWFC 2
Add
BLAST
Domaini782 – 84867VWFC 3
Add
BLAST
Domaini870 – 93061VWFC 4
Add
BLAST

Sequence similaritiesi

Belongs to the chordin family.
Contains 4 CHRD domains.
Contains 4 VWFC domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG85639.
GeneTreeiENSGT00730000110792.
HOGENOMiHOG000234370.
HOVERGENiHBG005330.
InParanoidiQ63148.
OMAiRDPGEGC.
OrthoDBiEOG7QNVK7.
PhylomeDBiQ63148.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07452. CHRD. 4 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63148-1 [UniParc]FASTAAdd to Basket

« Hide

MPSLPAPPAP RLLLGLLLLG SRPAGGTGPE APALPIRSEK EPLPVRGAAG    50
CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK 100
NIKPQCPTLA CRQPRQLPGH CCQTCPQDAE RSNLDPQPAG LVFEYPRDPE 150
HRSYSDRGEP GTGERTRGDG HTEDFVALLT GPRTQAVARA RVSLLRSSLR 200
FSISYQRLDR PSRVRFTDPT GNILFEHPAA PTQDGLVCGV WRAVPRLSVR 250
LLRAEQLRVA LVTPTHPSEE VWGPLIWQGA LTAETFSAIL TLEDPLQRGV 300
GGIALLTLSD TEDALHFLLL FRGLLGGLAH VPLKLQILHQ GQLLRELQAN 350
ASAQEPGFAE VLPSLTDQEM DWLVLGELQM VLEKMGGPEL RISGYITTRQ 400
SCDVLQSVLC GADALIPVQT GAAGSASFIL LGNGSLIYQV QVIGTGSEVV 450
AMTLETKPQR KNQRTVLCHM AGLQLGGHMA VGVCSGLGAR GAHMLLQNEL 500
FLNIGTKDFP DGELRGHVTA LCYSGHSAHY DRLPVPLAGA LVLPPVRSQA 550
AGHAWLSLDT HCHLHYEVLL AGLGGSEQGT VTAHLLGPPG MPGPQRLLKG 600
FYGSEAQGVV KDLEPVLLRH LTQGTASLLI TTKSNPRGEL RGQVHIASQC 650
EVGGLRLASE GVRMSLAPNG EAATSPMLPA GPGPEAPVPA KHGSSGRPRD 700
PNTCFFEGQQ RPHGARWAPN YDPLCSLCTC QRRTVICDPV VCPPPSCPHP 750
VQALDQCCPV CPEKQRSRDL PSLPNLEPGE GCYFDGDRSW RAAGTRWHPV 800
VPPFGLIKCA VCTCKGATGE VHCEKVQCPR LACAQPVRAN PTDCCKQCPV 850
GSGTHAKLGD PMQADGPRGC RFAGQWFPEN QSWHPSVPPF GEMSCITCRC 900
GAGVPHCERD DCSPPLSCGS GKESRCCSHC TAQRSSETRT LPELEKEAQR 950
S 951
Length:951
Mass (Da):102,007
Last modified:March 20, 2007 - v2
Checksum:iF7E2F509718C0EBE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti746 – 7494SCPH → RCSQ in BAA13128. 1 Publication
Sequence conflicti757 – 7571C → W in BAA13128. 1 Publication
Sequence conflicti762 – 7621P → S in BAA13128. 1 Publication
Sequence conflicti771 – 7711P → S in BAA13128. 1 Publication
Sequence conflicti810 – 8101A → G in BAA13128. 1 Publication
Sequence conflicti817 – 8182AT → VN in BAA13128. 1 Publication
Sequence conflicti823 – 8231C → S in BAA13128. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03079283 Genomic DNA. No translation available.
D86581 mRNA. Translation: BAA13128.1.
UniGeneiRn.29459.

Genome annotation databases

EnsembliENSRNOT00000002394; ENSRNOP00000002394; ENSRNOG00000001750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03079283 Genomic DNA. No translation available.
D86581 mRNA. Translation: BAA13128.1 .
UniGenei Rn.29459.

3D structure databases

ProteinModelPortali Q63148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000002394.

Proteomic databases

PaxDbi Q63148.
PRIDEi Q63148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000002394 ; ENSRNOP00000002394 ; ENSRNOG00000001750 .

Organism-specific databases

RGDi 620181. Chrd.

Phylogenomic databases

eggNOGi NOG85639.
GeneTreei ENSGT00730000110792.
HOGENOMi HOG000234370.
HOVERGENi HBG005330.
InParanoidi Q63148.
OMAi RDPGEGC.
OrthoDBi EOG7QNVK7.
PhylomeDBi Q63148.

Miscellaneous databases

PROi Q63148.

Gene expression databases

Genevestigatori Q63148.

Family and domain databases

InterProi IPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF07452. CHRD. 4 hits.
PF00093. VWC. 3 hits.
[Graphical view ]
PIRSFi PIRSF002496. Chordin. 1 hit.
SMARTi SM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view ]
PROSITEi PS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Kuroda S., Tokunaga C., Konishi H., Kikkawa U.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 653-828.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCHRD_RAT
AccessioniPrimary (citable) accession number: Q63148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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