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Protein

Chordin

Gene

Chrd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).By similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: Ensembl
  2. forebrain development Source: Ensembl
  3. gastrulation with mouth forming second Source: Ensembl
  4. mesoderm formation Source: Ensembl
  5. negative regulation of BMP signaling pathway Source: Ensembl
  6. negative regulation of cell migration Source: Ensembl
  7. negative regulation of osteoblast differentiation Source: Ensembl
  8. osteoblast differentiation Source: Ensembl
  9. positive regulation of cell adhesion Source: Ensembl
  10. positive regulation of mesenchymal cell proliferation Source: Ensembl
  11. skeletal system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Gene namesi
Name:Chrd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 11

Organism-specific databases

RGDi620181. Chrd.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 951925ChordinPRO_0000219088Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63148.
PRIDEiQ63148.

Expressioni

Gene expression databases

ExpressionAtlasiQ63148. baseline and differential.
GenevestigatoriQ63148.

Interactioni

Subunit structurei

Interacts with TWSG1 and/or BMP4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002394.

Structurei

3D structure databases

ProteinModelPortaliQ63148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12678VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini171 – 280110CHRD 1PROSITE-ProRule annotationAdd
BLAST
Domaini282 – 401120CHRD 2PROSITE-ProRule annotationAdd
BLAST
Domaini402 – 523122CHRD 3PROSITE-ProRule annotationAdd
BLAST
Domaini529 – 649121CHRD 4PROSITE-ProRule annotationAdd
BLAST
Domaini702 – 76261VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini782 – 84867VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini870 – 93061VWFC 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chordin family.Curated
Contains 4 CHRD domains.PROSITE-ProRule annotation
Contains 4 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG85639.
GeneTreeiENSGT00730000110792.
HOGENOMiHOG000234370.
HOVERGENiHBG005330.
InParanoidiQ63148.
OMAiRDPGEGC.
OrthoDBiEOG7QNVK7.
PhylomeDBiQ63148.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07452. CHRD. 4 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLPAPPAP RLLLGLLLLG SRPAGGTGPE APALPIRSEK EPLPVRGAAG
60 70 80 90 100
CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK
110 120 130 140 150
NIKPQCPTLA CRQPRQLPGH CCQTCPQDAE RSNLDPQPAG LVFEYPRDPE
160 170 180 190 200
HRSYSDRGEP GTGERTRGDG HTEDFVALLT GPRTQAVARA RVSLLRSSLR
210 220 230 240 250
FSISYQRLDR PSRVRFTDPT GNILFEHPAA PTQDGLVCGV WRAVPRLSVR
260 270 280 290 300
LLRAEQLRVA LVTPTHPSEE VWGPLIWQGA LTAETFSAIL TLEDPLQRGV
310 320 330 340 350
GGIALLTLSD TEDALHFLLL FRGLLGGLAH VPLKLQILHQ GQLLRELQAN
360 370 380 390 400
ASAQEPGFAE VLPSLTDQEM DWLVLGELQM VLEKMGGPEL RISGYITTRQ
410 420 430 440 450
SCDVLQSVLC GADALIPVQT GAAGSASFIL LGNGSLIYQV QVIGTGSEVV
460 470 480 490 500
AMTLETKPQR KNQRTVLCHM AGLQLGGHMA VGVCSGLGAR GAHMLLQNEL
510 520 530 540 550
FLNIGTKDFP DGELRGHVTA LCYSGHSAHY DRLPVPLAGA LVLPPVRSQA
560 570 580 590 600
AGHAWLSLDT HCHLHYEVLL AGLGGSEQGT VTAHLLGPPG MPGPQRLLKG
610 620 630 640 650
FYGSEAQGVV KDLEPVLLRH LTQGTASLLI TTKSNPRGEL RGQVHIASQC
660 670 680 690 700
EVGGLRLASE GVRMSLAPNG EAATSPMLPA GPGPEAPVPA KHGSSGRPRD
710 720 730 740 750
PNTCFFEGQQ RPHGARWAPN YDPLCSLCTC QRRTVICDPV VCPPPSCPHP
760 770 780 790 800
VQALDQCCPV CPEKQRSRDL PSLPNLEPGE GCYFDGDRSW RAAGTRWHPV
810 820 830 840 850
VPPFGLIKCA VCTCKGATGE VHCEKVQCPR LACAQPVRAN PTDCCKQCPV
860 870 880 890 900
GSGTHAKLGD PMQADGPRGC RFAGQWFPEN QSWHPSVPPF GEMSCITCRC
910 920 930 940 950
GAGVPHCERD DCSPPLSCGS GKESRCCSHC TAQRSSETRT LPELEKEAQR

S
Length:951
Mass (Da):102,007
Last modified:March 20, 2007 - v2
Checksum:iF7E2F509718C0EBE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti746 – 7494SCPH → RCSQ in BAA13128 (Ref. 2) Curated
Sequence conflicti757 – 7571C → W in BAA13128 (Ref. 2) Curated
Sequence conflicti762 – 7621P → S in BAA13128 (Ref. 2) Curated
Sequence conflicti771 – 7711P → S in BAA13128 (Ref. 2) Curated
Sequence conflicti810 – 8101A → G in BAA13128 (Ref. 2) Curated
Sequence conflicti817 – 8182AT → VN in BAA13128 (Ref. 2) Curated
Sequence conflicti823 – 8231C → S in BAA13128 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03079283 Genomic DNA. No translation available.
D86581 mRNA. Translation: BAA13128.1.
UniGeneiRn.29459.

Genome annotation databases

EnsembliENSRNOT00000002394; ENSRNOP00000002394; ENSRNOG00000001750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03079283 Genomic DNA. No translation available.
D86581 mRNA. Translation: BAA13128.1.
UniGeneiRn.29459.

3D structure databases

ProteinModelPortaliQ63148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002394.

Proteomic databases

PaxDbiQ63148.
PRIDEiQ63148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002394; ENSRNOP00000002394; ENSRNOG00000001750.

Organism-specific databases

RGDi620181. Chrd.

Phylogenomic databases

eggNOGiNOG85639.
GeneTreeiENSGT00730000110792.
HOGENOMiHOG000234370.
HOVERGENiHBG005330.
InParanoidiQ63148.
OMAiRDPGEGC.
OrthoDBiEOG7QNVK7.
PhylomeDBiQ63148.

Miscellaneous databases

PROiQ63148.

Gene expression databases

ExpressionAtlasiQ63148. baseline and differential.
GenevestigatoriQ63148.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamiPF07452. CHRD. 4 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. Kuroda S., Tokunaga C., Konishi H., Kikkawa U.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 653-828.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCHRD_RAT
AccessioniPrimary (citable) accession number: Q63148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 20, 2007
Last modified: January 7, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.