Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q63148

- CHRD_RAT

UniProt

Q63148 - CHRD_RAT

Protein

Chordin

Gene

Chrd

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: Ensembl
    2. forebrain development Source: Ensembl
    3. gastrulation with mouth forming second Source: Ensembl
    4. mesoderm formation Source: Ensembl
    5. negative regulation of BMP signaling pathway Source: Ensembl
    6. negative regulation of cell migration Source: Ensembl
    7. negative regulation of osteoblast differentiation Source: Ensembl
    8. osteoblast differentiation Source: Ensembl
    9. positive regulation of cell adhesion Source: Ensembl
    10. positive regulation of mesenchymal cell proliferation Source: Ensembl
    11. skeletal system development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chordin
    Gene namesi
    Name:Chrd
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 11

    Organism-specific databases

    RGDi620181. Chrd.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 951925ChordinPRO_0000219088Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi880 – 8801N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ63148.
    PRIDEiQ63148.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63148.

    Interactioni

    Subunit structurei

    Interacts with TWSG1 and/or BMP4.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000002394.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 12678VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini171 – 280110CHRD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini282 – 401120CHRD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini402 – 523122CHRD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini529 – 649121CHRD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini702 – 76261VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini782 – 84867VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini870 – 93061VWFC 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chordin family.Curated
    Contains 4 CHRD domains.PROSITE-ProRule annotation
    Contains 4 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG85639.
    GeneTreeiENSGT00730000110792.
    HOGENOMiHOG000234370.
    HOVERGENiHBG005330.
    InParanoidiQ63148.
    OMAiRDPGEGC.
    OrthoDBiEOG7QNVK7.
    PhylomeDBiQ63148.

    Family and domain databases

    InterProiIPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF07452. CHRD. 4 hits.
    PF00093. VWC. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002496. Chordin. 1 hit.
    SMARTiSM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view]
    PROSITEiPS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63148-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSLPAPPAP RLLLGLLLLG SRPAGGTGPE APALPIRSEK EPLPVRGAAG    50
    CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK 100
    NIKPQCPTLA CRQPRQLPGH CCQTCPQDAE RSNLDPQPAG LVFEYPRDPE 150
    HRSYSDRGEP GTGERTRGDG HTEDFVALLT GPRTQAVARA RVSLLRSSLR 200
    FSISYQRLDR PSRVRFTDPT GNILFEHPAA PTQDGLVCGV WRAVPRLSVR 250
    LLRAEQLRVA LVTPTHPSEE VWGPLIWQGA LTAETFSAIL TLEDPLQRGV 300
    GGIALLTLSD TEDALHFLLL FRGLLGGLAH VPLKLQILHQ GQLLRELQAN 350
    ASAQEPGFAE VLPSLTDQEM DWLVLGELQM VLEKMGGPEL RISGYITTRQ 400
    SCDVLQSVLC GADALIPVQT GAAGSASFIL LGNGSLIYQV QVIGTGSEVV 450
    AMTLETKPQR KNQRTVLCHM AGLQLGGHMA VGVCSGLGAR GAHMLLQNEL 500
    FLNIGTKDFP DGELRGHVTA LCYSGHSAHY DRLPVPLAGA LVLPPVRSQA 550
    AGHAWLSLDT HCHLHYEVLL AGLGGSEQGT VTAHLLGPPG MPGPQRLLKG 600
    FYGSEAQGVV KDLEPVLLRH LTQGTASLLI TTKSNPRGEL RGQVHIASQC 650
    EVGGLRLASE GVRMSLAPNG EAATSPMLPA GPGPEAPVPA KHGSSGRPRD 700
    PNTCFFEGQQ RPHGARWAPN YDPLCSLCTC QRRTVICDPV VCPPPSCPHP 750
    VQALDQCCPV CPEKQRSRDL PSLPNLEPGE GCYFDGDRSW RAAGTRWHPV 800
    VPPFGLIKCA VCTCKGATGE VHCEKVQCPR LACAQPVRAN PTDCCKQCPV 850
    GSGTHAKLGD PMQADGPRGC RFAGQWFPEN QSWHPSVPPF GEMSCITCRC 900
    GAGVPHCERD DCSPPLSCGS GKESRCCSHC TAQRSSETRT LPELEKEAQR 950
    S 951
    Length:951
    Mass (Da):102,007
    Last modified:March 20, 2007 - v2
    Checksum:iF7E2F509718C0EBE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti746 – 7494SCPH → RCSQ in BAA13128. 1 PublicationCurated
    Sequence conflicti757 – 7571C → W in BAA13128. 1 PublicationCurated
    Sequence conflicti762 – 7621P → S in BAA13128. 1 PublicationCurated
    Sequence conflicti771 – 7711P → S in BAA13128. 1 PublicationCurated
    Sequence conflicti810 – 8101A → G in BAA13128. 1 PublicationCurated
    Sequence conflicti817 – 8182AT → VN in BAA13128. 1 PublicationCurated
    Sequence conflicti823 – 8231C → S in BAA13128. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03079283 Genomic DNA. No translation available.
    D86581 mRNA. Translation: BAA13128.1.
    UniGeneiRn.29459.

    Genome annotation databases

    EnsembliENSRNOT00000002394; ENSRNOP00000002394; ENSRNOG00000001750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03079283 Genomic DNA. No translation available.
    D86581 mRNA. Translation: BAA13128.1 .
    UniGenei Rn.29459.

    3D structure databases

    ProteinModelPortali Q63148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000002394.

    Proteomic databases

    PaxDbi Q63148.
    PRIDEi Q63148.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000002394 ; ENSRNOP00000002394 ; ENSRNOG00000001750 .

    Organism-specific databases

    RGDi 620181. Chrd.

    Phylogenomic databases

    eggNOGi NOG85639.
    GeneTreei ENSGT00730000110792.
    HOGENOMi HOG000234370.
    HOVERGENi HBG005330.
    InParanoidi Q63148.
    OMAi RDPGEGC.
    OrthoDBi EOG7QNVK7.
    PhylomeDBi Q63148.

    Miscellaneous databases

    PROi Q63148.

    Gene expression databases

    Genevestigatori Q63148.

    Family and domain databases

    InterProi IPR016353. Chordin.
    IPR010895. CHRD.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF07452. CHRD. 4 hits.
    PF00093. VWC. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002496. Chordin. 1 hit.
    SMARTi SM00754. CHRD. 4 hits.
    SM00214. VWC. 4 hits.
    [Graphical view ]
    PROSITEi PS50933. CHRD. 4 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. Kuroda S., Tokunaga C., Konishi H., Kikkawa U.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 653-828.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCHRD_RAT
    AccessioniPrimary (citable) accession number: Q63148
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3