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Q63148 (CHRD_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chordin
Gene names
Name:Chrd
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length951 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes By similarity.

Subunit structure

Interacts with TWSG1 and/or BMP4 By similarity.

Subcellular location

Secreted By similarity.

Post-translational modification

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development By similarity.

Sequence similarities

Belongs to the chordin family.

Contains 4 CHRD domains.

Contains 4 VWFC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 951925Chordin
PRO_0000219088

Regions

Domain49 – 12678VWFC 1
Domain171 – 280110CHRD 1
Domain282 – 401120CHRD 2
Domain402 – 523122CHRD 3
Domain529 – 649121CHRD 4
Domain702 – 76261VWFC 2
Domain782 – 84867VWFC 3
Domain870 – 93061VWFC 4

Amino acid modifications

Glycosylation3501N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation8801N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict746 – 7494SCPH → RCSQ in BAA13128. Ref.2
Sequence conflict7571C → W in BAA13128. Ref.2
Sequence conflict7621P → S in BAA13128. Ref.2
Sequence conflict7711P → S in BAA13128. Ref.2
Sequence conflict8101A → G in BAA13128. Ref.2
Sequence conflict817 – 8182AT → VN in BAA13128. Ref.2
Sequence conflict8231C → S in BAA13128. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q63148 [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: F7E2F509718C0EBE

FASTA951102,007
        10         20         30         40         50         60 
MPSLPAPPAP RLLLGLLLLG SRPAGGTGPE APALPIRSEK EPLPVRGAAG CSFGGKVYAL 

        70         80         90        100        110        120 
DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK NIKPQCPTLA CRQPRQLPGH 

       130        140        150        160        170        180 
CCQTCPQDAE RSNLDPQPAG LVFEYPRDPE HRSYSDRGEP GTGERTRGDG HTEDFVALLT 

       190        200        210        220        230        240 
GPRTQAVARA RVSLLRSSLR FSISYQRLDR PSRVRFTDPT GNILFEHPAA PTQDGLVCGV 

       250        260        270        280        290        300 
WRAVPRLSVR LLRAEQLRVA LVTPTHPSEE VWGPLIWQGA LTAETFSAIL TLEDPLQRGV 

       310        320        330        340        350        360 
GGIALLTLSD TEDALHFLLL FRGLLGGLAH VPLKLQILHQ GQLLRELQAN ASAQEPGFAE 

       370        380        390        400        410        420 
VLPSLTDQEM DWLVLGELQM VLEKMGGPEL RISGYITTRQ SCDVLQSVLC GADALIPVQT 

       430        440        450        460        470        480 
GAAGSASFIL LGNGSLIYQV QVIGTGSEVV AMTLETKPQR KNQRTVLCHM AGLQLGGHMA 

       490        500        510        520        530        540 
VGVCSGLGAR GAHMLLQNEL FLNIGTKDFP DGELRGHVTA LCYSGHSAHY DRLPVPLAGA 

       550        560        570        580        590        600 
LVLPPVRSQA AGHAWLSLDT HCHLHYEVLL AGLGGSEQGT VTAHLLGPPG MPGPQRLLKG 

       610        620        630        640        650        660 
FYGSEAQGVV KDLEPVLLRH LTQGTASLLI TTKSNPRGEL RGQVHIASQC EVGGLRLASE 

       670        680        690        700        710        720 
GVRMSLAPNG EAATSPMLPA GPGPEAPVPA KHGSSGRPRD PNTCFFEGQQ RPHGARWAPN 

       730        740        750        760        770        780 
YDPLCSLCTC QRRTVICDPV VCPPPSCPHP VQALDQCCPV CPEKQRSRDL PSLPNLEPGE 

       790        800        810        820        830        840 
GCYFDGDRSW RAAGTRWHPV VPPFGLIKCA VCTCKGATGE VHCEKVQCPR LACAQPVRAN 

       850        860        870        880        890        900 
PTDCCKQCPV GSGTHAKLGD PMQADGPRGC RFAGQWFPEN QSWHPSVPPF GEMSCITCRC 

       910        920        930        940        950 
GAGVPHCERD DCSPPLSCGS GKESRCCSHC TAQRSSETRT LPELEKEAQR S 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway.
[2]Kuroda S., Tokunaga C., Konishi H., Kikkawa U.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 653-828.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR03079283 Genomic DNA. No translation available.
D86581 mRNA. Translation: BAA13128.1.
UniGeneRn.29459.

3D structure databases

ProteinModelPortalQ63148.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000002394.

Proteomic databases

PaxDbQ63148.
PRIDEQ63148.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000002394; ENSRNOP00000002394; ENSRNOG00000001750.

Organism-specific databases

RGD620181. Chrd.

Phylogenomic databases

eggNOGNOG85639.
GeneTreeENSGT00730000110792.
HOGENOMHOG000234370.
HOVERGENHBG005330.
InParanoidQ63148.
OMARDPGEGC.
OrthoDBEOG7QNVK7.
PhylomeDBQ63148.

Gene expression databases

GenevestigatorQ63148.

Family and domain databases

InterProIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_C.
[Graphical view]
PfamPF07452. CHRD. 4 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFPIRSF002496. Chordin. 1 hit.
SMARTSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ63148.

Entry information

Entry nameCHRD_RAT
AccessionPrimary (citable) accession number: Q63148
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 20, 2007
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families