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Protein

Chordin

Gene

Chrd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Chordin
Gene namesi
Name:Chrd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620181. Chrd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000021908827 – 951ChordinAdd BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi880N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ63148.
PRIDEiQ63148.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001750.
GenevisibleiQ63148. RN.

Interactioni

Subunit structurei

Interacts with TWSG1 and/or BMP4.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002394.

Structurei

3D structure databases

ProteinModelPortaliQ63148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 126VWFC 1PROSITE-ProRule annotationAdd BLAST78
Domaini171 – 280CHRD 1PROSITE-ProRule annotationAdd BLAST110
Domaini282 – 401CHRD 2PROSITE-ProRule annotationAdd BLAST120
Domaini402 – 523CHRD 3PROSITE-ProRule annotationAdd BLAST122
Domaini529 – 649CHRD 4PROSITE-ProRule annotationAdd BLAST121
Domaini702 – 762VWFC 2PROSITE-ProRule annotationAdd BLAST61
Domaini782 – 848VWFC 3PROSITE-ProRule annotationAdd BLAST67
Domaini870 – 930VWFC 4PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the chordin family.Curated
Contains 4 CHRD domains.PROSITE-ProRule annotation
Contains 4 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEDE. Eukaryota.
ENOG410XSBA. LUCA.
HOGENOMiHOG000234370.
HOVERGENiHBG005330.
InParanoidiQ63148.
OrthoDBiEOG091G11A0.
PhylomeDBiQ63148.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF07452. CHRD. 2 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLPAPPAP RLLLGLLLLG SRPAGGTGPE APALPIRSEK EPLPVRGAAG
60 70 80 90 100
CSFGGKVYAL DETWHPDLGE PFGVMRCVLC ACEAPQWARR GRGPGRVSCK
110 120 130 140 150
NIKPQCPTLA CRQPRQLPGH CCQTCPQDAE RSNLDPQPAG LVFEYPRDPE
160 170 180 190 200
HRSYSDRGEP GTGERTRGDG HTEDFVALLT GPRTQAVARA RVSLLRSSLR
210 220 230 240 250
FSISYQRLDR PSRVRFTDPT GNILFEHPAA PTQDGLVCGV WRAVPRLSVR
260 270 280 290 300
LLRAEQLRVA LVTPTHPSEE VWGPLIWQGA LTAETFSAIL TLEDPLQRGV
310 320 330 340 350
GGIALLTLSD TEDALHFLLL FRGLLGGLAH VPLKLQILHQ GQLLRELQAN
360 370 380 390 400
ASAQEPGFAE VLPSLTDQEM DWLVLGELQM VLEKMGGPEL RISGYITTRQ
410 420 430 440 450
SCDVLQSVLC GADALIPVQT GAAGSASFIL LGNGSLIYQV QVIGTGSEVV
460 470 480 490 500
AMTLETKPQR KNQRTVLCHM AGLQLGGHMA VGVCSGLGAR GAHMLLQNEL
510 520 530 540 550
FLNIGTKDFP DGELRGHVTA LCYSGHSAHY DRLPVPLAGA LVLPPVRSQA
560 570 580 590 600
AGHAWLSLDT HCHLHYEVLL AGLGGSEQGT VTAHLLGPPG MPGPQRLLKG
610 620 630 640 650
FYGSEAQGVV KDLEPVLLRH LTQGTASLLI TTKSNPRGEL RGQVHIASQC
660 670 680 690 700
EVGGLRLASE GVRMSLAPNG EAATSPMLPA GPGPEAPVPA KHGSSGRPRD
710 720 730 740 750
PNTCFFEGQQ RPHGARWAPN YDPLCSLCTC QRRTVICDPV VCPPPSCPHP
760 770 780 790 800
VQALDQCCPV CPEKQRSRDL PSLPNLEPGE GCYFDGDRSW RAAGTRWHPV
810 820 830 840 850
VPPFGLIKCA VCTCKGATGE VHCEKVQCPR LACAQPVRAN PTDCCKQCPV
860 870 880 890 900
GSGTHAKLGD PMQADGPRGC RFAGQWFPEN QSWHPSVPPF GEMSCITCRC
910 920 930 940 950
GAGVPHCERD DCSPPLSCGS GKESRCCSHC TAQRSSETRT LPELEKEAQR

S
Length:951
Mass (Da):102,007
Last modified:March 20, 2007 - v2
Checksum:iF7E2F509718C0EBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti746 – 749SCPH → RCSQ in BAA13128 (Ref. 2) Curated4
Sequence conflicti757C → W in BAA13128 (Ref. 2) Curated1
Sequence conflicti762P → S in BAA13128 (Ref. 2) Curated1
Sequence conflicti771P → S in BAA13128 (Ref. 2) Curated1
Sequence conflicti810A → G in BAA13128 (Ref. 2) Curated1
Sequence conflicti817 – 818AT → VN in BAA13128 (Ref. 2) Curated2
Sequence conflicti823C → S in BAA13128 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03079283 Genomic DNA. No translation available.
D86581 mRNA. Translation: BAA13128.1.
UniGeneiRn.29459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03079283 Genomic DNA. No translation available.
D86581 mRNA. Translation: BAA13128.1.
UniGeneiRn.29459.

3D structure databases

ProteinModelPortaliQ63148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002394.

Proteomic databases

PaxDbiQ63148.
PRIDEiQ63148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620181. Chrd.

Phylogenomic databases

eggNOGiENOG410IEDE. Eukaryota.
ENOG410XSBA. LUCA.
HOGENOMiHOG000234370.
HOVERGENiHBG005330.
InParanoidiQ63148.
OrthoDBiEOG091G11A0.
PhylomeDBiQ63148.

Miscellaneous databases

PROiQ63148.

Gene expression databases

BgeeiENSRNOG00000001750.
GenevisibleiQ63148. RN.

Family and domain databases

InterProiIPR016353. Chordin.
IPR010895. CHRD.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF07452. CHRD. 2 hits.
PF00093. VWC. 3 hits.
[Graphical view]
PIRSFiPIRSF002496. Chordin. 1 hit.
SMARTiSM00754. CHRD. 4 hits.
SM00214. VWC. 4 hits.
[Graphical view]
PROSITEiPS50933. CHRD. 4 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHRD_RAT
AccessioniPrimary (citable) accession number: Q63148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.