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Protein

Complement component receptor 1-like protein

Gene

Cr1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity, Pregnancy

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.
R-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component receptor 1-like protein
Alternative name(s):
Antigen 5I2
Complement regulatory protein Crry
Gene namesi
Name:Cr1l
Synonyms:Crry
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2399. Cr1l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 482ExtracellularSequence analysisAdd BLAST447
Transmembranei483 – 503HelicalSequence analysisAdd BLAST21
Topological domaini504 – 559CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000023897936 – 559Complement component receptor 1-like proteinAdd BLAST524

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 81PROSITE-ProRule annotation1 Publication
Glycosylationi53O-linked (GalNAc...)Sequence analysis1
Disulfide bondi68 ↔ 94PROSITE-ProRule annotation1 Publication
Disulfide bondi99 ↔ 140PROSITE-ProRule annotation1 Publication
Disulfide bondi126 ↔ 156PROSITE-ProRule annotation1 Publication
Disulfide bondi161 ↔ 210PROSITE-ProRule annotation1 Publication
Disulfide bondi190 ↔ 227PROSITE-ProRule annotation1 Publication
Disulfide bondi233 ↔ 275PROSITE-ProRule annotation1 Publication
Disulfide bondi261 ↔ 288PROSITE-ProRule annotation1 Publication
Disulfide bondi294 ↔ 336PROSITE-ProRule annotation
Disulfide bondi322 ↔ 352PROSITE-ProRule annotation
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi357 ↔ 400PROSITE-ProRule annotation
Disulfide bondi386 ↔ 413PROSITE-ProRule annotation
Disulfide bondi419 ↔ 462PROSITE-ProRule annotation
Disulfide bondi448 ↔ 475PROSITE-ProRule annotation
Modified residuei527PhosphoserineCombined sources1
Modified residuei531PhosphoserineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei540PhosphothreonineBy similarity1
Modified residuei554PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63135.
PRIDEiQ63135.

PTM databases

iPTMnetiQ63135.
PhosphoSitePlusiQ63135.

Expressioni

Gene expression databases

ExpressionAtlasiQ63135. baseline and differential.
GenevisibleiQ63135. RN.

Interactioni

Subunit structurei

Interacts with C3b.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010798.

Structurei

Secondary structure

1559
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 51Combined sources7
Beta strandi63 – 68Combined sources6
Beta strandi76 – 81Combined sources6
Beta strandi108 – 114Combined sources7
Beta strandi121 – 126Combined sources6
Beta strandi130 – 134Combined sources5
Beta strandi136 – 143Combined sources8
Beta strandi146 – 151Combined sources6
Beta strandi155 – 158Combined sources4
Beta strandi170 – 173Combined sources4
Beta strandi185 – 190Combined sources6
Beta strandi200 – 204Combined sources5
Beta strandi206 – 222Combined sources17
Beta strandi226 – 229Combined sources4
Beta strandi241 – 243Combined sources3
Beta strandi249 – 252Combined sources4
Beta strandi256 – 261Combined sources6
Beta strandi266 – 269Combined sources4
Beta strandi271 – 276Combined sources6
Turni277 – 279Combined sources3
Beta strandi280 – 283Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NTJmodel-A34-353[»]
2XRBX-ray2.50A1-288[»]
2XRDX-ray3.50A1-288[»]
ProteinModelPortaliQ63135.
SMRiQ63135.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63135.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 96Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini97 – 158Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini159 – 229Sushi 3PROSITE-ProRule annotationAdd BLAST71
Domaini231 – 290Sushi 4PROSITE-ProRule annotationAdd BLAST60
Domaini292 – 354Sushi 5PROSITE-ProRule annotationAdd BLAST63
Domaini355 – 415Sushi 6PROSITE-ProRule annotationAdd BLAST61
Domaini417 – 477Sushi 7PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 7 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000111977.
HOVERGENiHBG081346.
InParanoidiQ63135.
KOiK04005.
PhylomeDBiQ63135.
TreeFamiTF334137.

Family and domain databases

CDDicd00033. CCP. 7 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 7 hits.
[Graphical view]
SMARTiSM00032. CCP. 7 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 7 hits.
PROSITEiPS50923. SUSHI. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q63135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEASSPLDPV GRLVAFCRGG VHLAVLLLFL SPSTLGQCPA PPLFPYAKPI
60 70 80 90 100
NPTDESTFPV GTSLKYECRP GYIKRQFSIT CEVNSVWTSP QDVCIRKQCE
110 120 130 140 150
TPLDPQNGIV HVNTDIRFGS SITYTCNEGY RLIGSSSAMC IISDQSVAWD
160 170 180 190 200
AEAPICESIP CEIPPSIPNG DFFSPNREDF HYGMVVTYQC NTDARGKKLF
210 220 230 240 250
NLVGEPSIHC TSIDGQVGVW SGPPPQCIEL NKCTPPHVEN AVIVSKNKSL
260 270 280 290 300
FSLRDMVEFR CQDGFMMKGD SSVYCRSLNR WEPQLPSCFK VKSCGAFLGE
310 320 330 340 350
LPNGHVFVPQ NLQLGAKVTF VCNTGYQLKG NSSSHCVLDG VESIWNSSVP
360 370 380 390 400
VCEQVICKLP QDMSGFQKGL QMKKDYYYGD NVALECEDGY TLEGSSQSQC
410 420 430 440 450
QSDASWDPPL PKCVSQVICK LPQDMSGFQK GLQMKKDYYY GDNVALECED
460 470 480 490 500
GYTLEGSSQS QCQSDASWDP PLPKCVSRSN SGLIAGIFIG IIVLILFIIF
510 520 530 540 550
SYWMIMKFKK RNSTNEKCKE VGIYLNSKED SCVQPQSLLT SQENNSTSSP

ARNSLTQEV
Length:559
Mass (Da):61,680
Last modified:November 1, 1996 - v1
Checksum:i29E10F6A21DB9B6E
GO
Isoform 2 (identifier: Q63135-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-415: Missing.

Show »
Length:497
Mass (Da):54,787
Checksum:i177AC11EE0F1AD1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66Y → Q AA sequence (PubMed:8144902).Curated1
Sequence conflicti69R → Q AA sequence (PubMed:8144902).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019051354 – 415Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42114 mRNA. Translation: BAA07698.1.
D42115 mRNA. Translation: BAA22548.1.
L36532 mRNA. Translation: AAA91821.1.
BC061736 mRNA. Translation: AAH61736.1.
PIRiJC2054.
RefSeqiNP_001005265.1. NM_001005265.1. [Q63135-2]
NP_001005330.1. NM_001005330.1.
NP_062174.1. NM_019301.2. [Q63135-1]
UniGeneiRn.5825.

Genome annotation databases

EnsembliENSRNOT00000010799; ENSRNOP00000010798; ENSRNOG00000008193. [Q63135-1]
ENSRNOT00000084320; ENSRNOP00000072622; ENSRNOG00000008193. [Q63135-2]
GeneIDi54243.
KEGGirno:54243.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42114 mRNA. Translation: BAA07698.1.
D42115 mRNA. Translation: BAA22548.1.
L36532 mRNA. Translation: AAA91821.1.
BC061736 mRNA. Translation: AAH61736.1.
PIRiJC2054.
RefSeqiNP_001005265.1. NM_001005265.1. [Q63135-2]
NP_001005330.1. NM_001005330.1.
NP_062174.1. NM_019301.2. [Q63135-1]
UniGeneiRn.5825.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NTJmodel-A34-353[»]
2XRBX-ray2.50A1-288[»]
2XRDX-ray3.50A1-288[»]
ProteinModelPortaliQ63135.
SMRiQ63135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010798.

PTM databases

iPTMnetiQ63135.
PhosphoSitePlusiQ63135.

Proteomic databases

PaxDbiQ63135.
PRIDEiQ63135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010799; ENSRNOP00000010798; ENSRNOG00000008193. [Q63135-1]
ENSRNOT00000084320; ENSRNOP00000072622; ENSRNOG00000008193. [Q63135-2]
GeneIDi54243.
KEGGirno:54243.

Organism-specific databases

CTDi1379.
RGDi2399. Cr1l.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118803.
HOGENOMiHOG000111977.
HOVERGENiHBG081346.
InParanoidiQ63135.
KOiK04005.
PhylomeDBiQ63135.
TreeFamiTF334137.

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.
R-RNO-977606. Regulation of Complement cascade.

Miscellaneous databases

EvolutionaryTraceiQ63135.
PROiQ63135.

Gene expression databases

ExpressionAtlasiQ63135. baseline and differential.
GenevisibleiQ63135. RN.

Family and domain databases

CDDicd00033. CCP. 7 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 7 hits.
[Graphical view]
SMARTiSM00032. CCP. 7 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 7 hits.
PROSITEiPS50923. SUSHI. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCR1L_RAT
AccessioniPrimary (citable) accession number: Q63135
Secondary accession number(s): Q63612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.