Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Canalicular multispecific organic anion transporter 1

Gene

Abcc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates hepatobiliary excretion of numerous organic anions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi667 – 674ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1330 – 1337ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • organic anion transmembrane transporter activity Source: RGD
  • protein domain specific binding Source: RGD

GO - Biological processi

  • antibiotic metabolic process Source: RGD
  • benzylpenicillin metabolic process Source: RGD
  • canalicular bile acid transport Source: RGD
  • cellular chloride ion homeostasis Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to interleukin-6 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • drug transmembrane transport Source: RGD
  • female pregnancy Source: RGD
  • mercury ion transport Source: RGD
  • organic anion transport Source: RGD
  • prostaglandin transport Source: RGD
  • response to antineoplastic agent Source: RGD
  • response to arsenic-containing substance Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to heat Source: RGD
  • response to methotrexate Source: RGD
  • response to oxidative stress Source: RGD
  • response to steroid hormone Source: RGD
  • thyroid hormone transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-382556. ABC-family proteins mediated transport.
SABIO-RKQ63120.

Names & Taxonomyi

Protein namesi
Recommended name:
Canalicular multispecific organic anion transporter 1
Alternative name(s):
ATP-binding cassette sub-family C member 2
Canalicular multidrug resistance protein
Multidrug resistance-associated protein 2
Gene namesi
Name:Abcc2
Synonyms:Cmoat, Cmrp, Mrp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2366. Abcc2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularBy similarityAdd BLAST26
Transmembranei27 – 47Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini48 – 67CytoplasmicBy similarityAdd BLAST20
Transmembranei68 – 88Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini89 – 92ExtracellularBy similarity4
Transmembranei93 – 113Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini114 – 125CytoplasmicBy similarityAdd BLAST12
Transmembranei126 – 146Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini147 – 164ExtracellularBy similarityAdd BLAST18
Transmembranei165 – 185Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini186 – 309CytoplasmicBy similarityAdd BLAST124
Transmembranei310 – 330Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini331 – 356ExtracellularBy similarityAdd BLAST26
Transmembranei357 – 377Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini378 – 433CytoplasmicBy similarityAdd BLAST56
Transmembranei434 – 454Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini455 – 457ExtracellularBy similarity3
Transmembranei458 – 478Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini479 – 540CytoplasmicBy similarityAdd BLAST62
Transmembranei541 – 561Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini562 – 583ExtracellularBy similarityAdd BLAST22
Transmembranei584 – 604Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini605 – 967CytoplasmicBy similarityAdd BLAST363
Transmembranei968 – 988Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini989 – 1029ExtracellularBy similarityAdd BLAST41
Transmembranei1030 – 1050Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1051 – 1093CytoplasmicBy similarityAdd BLAST43
Transmembranei1094 – 1114Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1115ExtracellularBy similarity1
Transmembranei1116 – 1136Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1137 – 1207CytoplasmicBy similarityAdd BLAST71
Transmembranei1208 – 1228Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1229 – 1230ExtracellularBy similarity2
Transmembranei1231 – 1251Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1252 – 1541CytoplasmicBy similarityAdd BLAST290

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • brush border membrane Source: RGD
  • cell surface Source: Ensembl
  • integral component of plasma membrane Source: Ensembl
  • intercellular canaliculus Source: Ensembl
  • membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Abcc2 are a cause of hereditary conjugated hyperbilirubinemia (EHBR).

Chemistry databases

ChEMBLiCHEMBL2073676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933591 – 1541Canalicular multispecific organic anion transporter 1Add BLAST1541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Modified residuei279PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei874PhosphoserineCombined sources1
Modified residuei922PhosphoserineBy similarity1
Modified residuei926PhosphoserineBy similarity1
Glycosylationi1007N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1010N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1011N-linked (GlcNAc...)Sequence analysis1
Modified residuei1434PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63120.
PRIDEiQ63120.

PTM databases

iPTMnetiQ63120.
PhosphoSitePlusiQ63120.

Expressioni

Tissue specificityi

Mainly expressed in the liver.

Gene expression databases

BgeeiENSRNOG00000046727.
GenevisibleiQ63120. RN.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

IntActiQ63120. 1 interactor.
MINTiMINT-7138043.
STRINGi10116.ENSRNOP00000064799.

Chemistry databases

BindingDBiQ63120.

Structurei

3D structure databases

ProteinModelPortaliQ63120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini318 – 601ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini633 – 857ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini975 – 1260ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST286
Domaini1296 – 1530ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ63120.
KOiK05666.
OMAiQSVMVFL.
OrthoDBiEOG091G00IN.
PhylomeDBiQ63120.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030247. ABCC2.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF176. PTHR24223:SF176. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKFCNSTFW DLSLLESPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYSV
60 70 80 90 100
YRSRTKRSSI TKFYLAKQVF VVFLLILAAI DLSLALTEDT GQATVPPVRY
110 120 130 140 150
TNPILYLCTW LLVLAVQHSR QWCVRKNSWF LSLFWILSVL CGVFQFQTLI
160 170 180 190 200
RALLKDSKSN MAYSYLFFVS YGFQIVLLIL TAFSGPSDST QTPSVTASFL
210 220 230 240 250
SSITFSWYDR TVLKGYKHPL TLEDVWDIDE GFKTRSVTSK FEAAMTKDLQ
260 270 280 290 300
KARQAFQRRL QKSQRKPEAT LHGLNKKQSQ SQDVLVLEEA KKKSEKTTKD
310 320 330 340 350
YPKSWLIKSL FKTFHVVILK SFILKLIHDL LVFLNPQLLK LLIGFVKSSN
360 370 380 390 400
SYVWFGYICA ILMFAVTLIQ SFCLQSYFQH CFVLGMCVRT TVMSSIYKKA
410 420 430 440 450
LTLSNLARKQ YTIGETVNLM SVDSQKLMDA TNYMQLVWSS VIQITLSIFF
460 470 480 490 500
LWRELGPSIL AGVGVMVLLI PVNGVLATKI RNIQVQNMKN KDKRLKIMNE
510 520 530 540 550
ILSGIKILKY FAWEPSFQEQ VQGIRKKELK NLLRFGQLQS LLIFILQITP
560 570 580 590 600
ILVSVVTFSV YVLVDSANVL NAEKAFTSIT LFNILRFPLS MLPMVTSSIL
610 620 630 640 650
QASVSVDRLE RYLGGDDLDT SAIRRVSNFD KAVKFSEASF TWDPDLEATI
660 670 680 690 700
QDVNLDIKPG QLVAVVGTVG SGKSSLVSAM LGEMENVHGH ITIQGSTAYV
710 720 730 740 750
PQQSWIQNGT IKDNILFGSE YNEKKYQQVL KACALLPDLE ILPGGDMAEI
760 770 780 790 800
GEKGINLSGG QKQRVSLARA AYQDADIYIL DDPLSAVDAH VGKHIFNKVV
810 820 830 840 850
GPNGLLAGKT RIFVTHGIHF LPQVDEIVVL GKGTILEKGS YRDLLDKKGV
860 870 880 890 900
FARNWKTFMK HSGPEGEATV NNDSEAEDDD DGLIPTMEEI PEDAASLAMR
910 920 930 940 950
RENSLRRTLS RSSRSSSRRG KSLKNSLKIK NVNVLKEKEK EVEGQKLIKK
960 970 980 990 1000
EFVETGKVKF SIYLKYLQAV GWWSILFIIL FYGLNNVAFI GSNLWLSAWT
1010 1020 1030 1040 1050
SDSDNLNGTN NSSSHRDMRI GVFGALGLAQ GICLLISTLW SIYACRNASK
1060 1070 1080 1090 1100
ALHGQLLTNI LRAPMRFFDT TPTGRIVNRF SGDISTVDDL LPQTLRSWMM
1110 1120 1130 1140 1150
CFFGIAGTLV MICMATPVFA IIIIPLSILY ISVQVFYVAT SRQLRRLDSV
1160 1170 1180 1190 1200
TKSPIYSHFS ETVTGLPIIR AFEHQQRFLA WNEKQIDINQ KCVFSWITSN
1210 1220 1230 1240 1250
RWLAIRLELV GNLVVFCSAL LLVIYRKTLT GDVVGFVLSN ALNITQTLNW
1260 1270 1280 1290 1300
LVRMTSEAET NIVAVERISE YINVENEAPW VTDKRPPADW PRHGEIQFNN
1310 1320 1330 1340 1350
YQVRYRPELD LVLKGITCNI KSGEKVGVVG RTGAGKSSLT NCLFRILESA
1360 1370 1380 1390 1400
GGQIIIDGID VASIGLHDLR ERLTIIPQDP ILFSGSLRMN LDPFNKYSDE
1410 1420 1430 1440 1450
EVWRALELAH LRSFVSGLQL GLLSEVTEGG DNLSIGQRQL LCLGRAVLRK
1460 1470 1480 1490 1500
SKILVLDEAT AAVDLETDSL IQTTIRKEFS QCTVITIAHR LHTIMDSDKI
1510 1520 1530 1540
MVLDNGKIVE YGSPEELLSN RGSFYLMAKE AGIENVNHTE L
Length:1,541
Mass (Da):173,384
Last modified:November 1, 1996 - v1
Checksum:iD5FB55571BFDDB39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti420M → V in BAA13016 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49379 mRNA. Translation: AAC42087.1.
X96393 mRNA. Translation: CAA65257.1.
D86086 mRNA. Translation: BAA13016.1.
PIRiS71839.
RefSeqiNP_036965.1. NM_012833.2.
UniGeneiRn.10265.

Genome annotation databases

EnsembliENSRNOT00000070861; ENSRNOP00000064799; ENSRNOG00000046727.
GeneIDi25303.
KEGGirno:25303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L49379 mRNA. Translation: AAC42087.1.
X96393 mRNA. Translation: CAA65257.1.
D86086 mRNA. Translation: BAA13016.1.
PIRiS71839.
RefSeqiNP_036965.1. NM_012833.2.
UniGeneiRn.10265.

3D structure databases

ProteinModelPortaliQ63120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63120. 1 interactor.
MINTiMINT-7138043.
STRINGi10116.ENSRNOP00000064799.

Chemistry databases

BindingDBiQ63120.
ChEMBLiCHEMBL2073676.

PTM databases

iPTMnetiQ63120.
PhosphoSitePlusiQ63120.

Proteomic databases

PaxDbiQ63120.
PRIDEiQ63120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000070861; ENSRNOP00000064799; ENSRNOG00000046727.
GeneIDi25303.
KEGGirno:25303.

Organism-specific databases

CTDi1244.
RGDi2366. Abcc2.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG108314.
InParanoidiQ63120.
KOiK05666.
OMAiQSVMVFL.
OrthoDBiEOG091G00IN.
PhylomeDBiQ63120.

Enzyme and pathway databases

ReactomeiR-RNO-382556. ABC-family proteins mediated transport.
SABIO-RKQ63120.

Miscellaneous databases

PROiQ63120.

Gene expression databases

BgeeiENSRNOG00000046727.
GenevisibleiQ63120. RN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030247. ABCC2.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF176. PTHR24223:SF176. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP2_RAT
AccessioniPrimary (citable) accession number: Q63120
Secondary accession number(s): Q63145
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.