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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418555 G alpha (s) signalling events
R-RNO-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Cgrpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2255 Calcrl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 146ExtracellularSequence analysisAdd BLAST123
Transmembranei147 – 166Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini167 – 173CytoplasmicSequence analysis7
Transmembranei174 – 193Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini194 – 213ExtracellularSequence analysisAdd BLAST20
Transmembranei214 – 236Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini237 – 253CytoplasmicSequence analysisAdd BLAST17
Transmembranei254 – 273Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini274 – 289ExtracellularSequence analysisAdd BLAST16
Transmembranei290 – 313Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini314 – 336CytoplasmicSequence analysisAdd BLAST23
Transmembranei337 – 354Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini355 – 366ExtracellularSequence analysisAdd BLAST12
Transmembranei367 – 388Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini389 – 464CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4755
GuidetoPHARMACOLOGYi47

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001281324 – 464Calcitonin gene-related peptide type 1 receptorAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 74By similarity
Disulfide bondi65 ↔ 105By similarity
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi88 ↔ 127By similarity
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei420PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63118
PRIDEiQ63118

PTM databases

iPTMnetiQ63118
PhosphoSitePlusiQ63118

Expressioni

Gene expression databases

BgeeiENSRNOG00000054695
GenevisibleiQ63118 RN

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006462

Chemistry databases

BindingDBiQ63118

Structurei

3D structure databases

ProteinModelPortaliQ63118
SMRiQ63118
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00900000140884
HOGENOMiHOG000230695
HOVERGENiHBG102129
InParanoidiQ63118
KOiK04577
OMAiHCPDYFQ
OrthoDBiEOG091G027C
PhylomeDBiQ63118
TreeFamiTF315710

Family and domain databases

CDDicd15274 7tmB1_calcitonin_R, 1 hit
Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR003287 GCPR_2_calcitonin_rcpt_fam
IPR017981 GPCR_2-like
IPR003289 GPCR_2_CGRP1_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01351 CGRPRECEPTOR
PR01350 CTRFAMILY
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDKKCTLCF LFLLLLNMAL IAAESEEGAN QTDLGVTRNK IMTAQYECYQ
60 70 80 90 100
KIMQDPIQQG EGLYCNRTWD GWLCWNDVAA GTESMQYCPD YFQDFDPSEK
110 120 130 140 150
VTKICDQDGN WFRHPDSNRT WTNYTLCNNS THEKVKTALN LFYLTIIGHG
160 170 180 190 200
LSIASLIISL IIFFYFKSLS CQRITLHKNL FFSFVCNSIV TIIHLTAVAN
210 220 230 240 250
NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ
260 270 280 290 300
HLMWYYFLGW GFPLLPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
310 320 330 340 350
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV
360 370 380 390 400
LFPWRPEGKV AEEVYDYVMH ILMHYQGLLV STIFCFFNGE VQAILRRNWN
410 420 430 440 450
QYKIQFGNGF SHSDALRSAS YTVSTISDVQ GYSHDCPTEH LNGKSIQDIE
460
NVALKPEKMY DLVM
Length:464
Mass (Da):53,329
Last modified:November 1, 1997 - v1
Checksum:i7373EC94B0FBC33C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70658 mRNA Translation: CAA49997.1
PIRiI60194
RefSeqiNP_036849.1, NM_012717.1
XP_006234500.1, XM_006234438.3
XP_006234501.1, XM_006234439.3
UniGeneiRn.11202

Genome annotation databases

EnsembliENSRNOT00000078645; ENSRNOP00000074452; ENSRNOG00000054695
ENSRNOT00000088170; ENSRNOP00000070720; ENSRNOG00000054695
GeneIDi25029
KEGGirno:25029
UCSCiRGD:2255 rat

Similar proteinsi

Entry informationi

Entry nameiCALRL_RAT
AccessioniPrimary (citable) accession number: Q63118
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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