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Q63118 (CALRL_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcitonin gene-related peptide type 1 receptor

Short name=CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene names
Name:Calcrl
Synonyms:Cgrpr
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 By similarity. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase By similarity.

Subunit structure

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-activating G-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

angiogenesis

Inferred from electronic annotation. Source: Ensembl

cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

calcium ion transport

Inferred from electronic annotation. Source: Ensembl

cellular response to sucrose stimulus

Inferred from electronic annotation. Source: Ensembl

heart development

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response

Inferred from mutant phenotype PubMed 17363466. Source: RGD

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

receptor internalization

Inferred from electronic annotation. Source: Ensembl

regulation of muscle contraction

Inferred from mutant phenotype PubMed 17363466. Source: RGD

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosome

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadrenomedullin receptor activity

Inferred from electronic annotation. Source: Ensembl

calcitonin gene-related polypeptide receptor activity

Inferred from electronic annotation. Source: Ensembl

calcitonin receptor activity

Inferred from mutant phenotype PubMed 17363466. Source: RGD

protein transporter activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 464441Calcitonin gene-related peptide type 1 receptor
PRO_0000012813

Regions

Topological domain24 – 146123Extracellular Potential
Transmembrane147 – 16620Helical; Name=1; Potential
Topological domain167 – 1737Cytoplasmic Potential
Transmembrane174 – 19320Helical; Name=2; Potential
Topological domain194 – 21320Extracellular Potential
Transmembrane214 – 23623Helical; Name=3; Potential
Topological domain237 – 25317Cytoplasmic Potential
Transmembrane254 – 27320Helical; Name=4; Potential
Topological domain274 – 28916Extracellular Potential
Transmembrane290 – 31324Helical; Name=5; Potential
Topological domain314 – 33623Cytoplasmic Potential
Transmembrane337 – 35418Helical; Name=6; Potential
Topological domain355 – 36612Extracellular Potential
Transmembrane367 – 38822Helical; Name=7; Potential
Topological domain389 – 46476Cytoplasmic Potential

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation1291N-linked (GlcNAc...) Potential
Disulfide bond48 ↔ 74 By similarity
Disulfide bond65 ↔ 105 By similarity
Disulfide bond88 ↔ 127 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q63118 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 7373EC94B0FBC33C

FASTA46453,329
        10         20         30         40         50         60 
MMDKKCTLCF LFLLLLNMAL IAAESEEGAN QTDLGVTRNK IMTAQYECYQ KIMQDPIQQG 

        70         80         90        100        110        120 
EGLYCNRTWD GWLCWNDVAA GTESMQYCPD YFQDFDPSEK VTKICDQDGN WFRHPDSNRT 

       130        140        150        160        170        180 
WTNYTLCNNS THEKVKTALN LFYLTIIGHG LSIASLIISL IIFFYFKSLS CQRITLHKNL 

       190        200        210        220        230        240 
FFSFVCNSIV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL 

       250        260        270        280        290        300 
IVVAVFAEKQ HLMWYYFLGW GFPLLPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA 

       310        320        330        340        350        360 
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LFPWRPEGKV 

       370        380        390        400        410        420 
AEEVYDYVMH ILMHYQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNGF SHSDALRSAS 

       430        440        450        460 
YTVSTISDVQ GYSHDCPTEH LNGKSIQDIE NVALKPEKMY DLVM 

« Hide

References

[1]"A new calcitonin-receptor-like sequence in rat pulmonary blood vessels."
Njuki F., Nicholl C.G., Howard A., Mak J.C., Barnes P.J., Girgis S.I., Legon S.
Clin. Sci. 85:385-388(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70658 mRNA. Translation: CAA49997.1.
PIRI60194.
RefSeqNP_036849.1. NM_012717.1.
XP_006234500.1. XM_006234438.1.
XP_006234501.1. XM_006234439.1.
UniGeneRn.11202.

3D structure databases

ProteinModelPortalQ63118.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1504930.
STRING10116.ENSRNOP00000006462.

Chemistry

BindingDBQ63118.
ChEMBLCHEMBL4755.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ63118.

Proteomic databases

PRIDEQ63118.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006462; ENSRNOP00000006462; ENSRNOG00000004622.
GeneID25029.
KEGGrno:25029.
UCSCRGD:2255. rat.

Organism-specific databases

CTD10203.
RGD2255. Calcrl.

Phylogenomic databases

eggNOGNOG255868.
GeneTreeENSGT00750000117654.
HOGENOMHOG000230695.
HOVERGENHBG102129.
InParanoidQ63118.
KOK04577.
OMALCWNDVA.
OrthoDBEOG712TW2.
PhylomeDBQ63118.
TreeFamTF315710.

Gene expression databases

GenevestigatorQ63118.

Family and domain databases

InterProIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio605171.
PROQ63118.

Entry information

Entry nameCALRL_RAT
AccessionPrimary (citable) accession number: Q63118
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries