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Q63118

- CALRL_RAT

UniProt

Q63118 - CALRL_RAT

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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.By similarity

GO - Molecular functioni

  1. adrenomedullin receptor activity Source: Ensembl
  2. calcitonin gene-related peptide receptor activity Source: Ensembl
  3. calcitonin receptor activity Source: RGD
  4. protein transporter activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. angiogenesis Source: Ensembl
  3. calcium ion transport Source: Ensembl
  4. cAMP biosynthetic process Source: Ensembl
  5. cellular response to sucrose stimulus Source: Ensembl
  6. heart development Source: Ensembl
  7. negative regulation of inflammatory response Source: RGD
  8. positive regulation of cAMP biosynthetic process Source: Ensembl
  9. positive regulation of smooth muscle cell proliferation Source: Ensembl
  10. receptor internalization Source: Ensembl
  11. regulation of muscle contraction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Cgrpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi2255. Calcrl.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. endosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosome Source: Ensembl
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 464441Calcitonin gene-related peptide type 1 receptorPRO_0000012813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi48 ↔ 74By similarity
Disulfide bondi65 ↔ 105By similarity
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi88 ↔ 127By similarity
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ63118.

PTM databases

PhosphoSiteiQ63118.

Expressioni

Gene expression databases

GenevestigatoriQ63118.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.By similarity

Protein-protein interaction databases

MINTiMINT-1504930.
STRINGi10116.ENSRNOP00000006462.

Structurei

3D structure databases

ProteinModelPortaliQ63118.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 146123ExtracellularSequence AnalysisAdd
BLAST
Topological domaini167 – 1737CytoplasmicSequence Analysis
Topological domaini194 – 21320ExtracellularSequence AnalysisAdd
BLAST
Topological domaini237 – 25317CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini274 – 28916ExtracellularSequence AnalysisAdd
BLAST
Topological domaini314 – 33623CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini355 – 36612ExtracellularSequence AnalysisAdd
BLAST
Topological domaini389 – 46476CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei147 – 16620Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei174 – 19320Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei214 – 23623Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei254 – 27320Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei290 – 31324Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei337 – 35418Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei367 – 38822Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ63118.
KOiK04577.
OMAiLCWNDVA.
OrthoDBiEOG712TW2.
PhylomeDBiQ63118.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63118-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDKKCTLCF LFLLLLNMAL IAAESEEGAN QTDLGVTRNK IMTAQYECYQ
60 70 80 90 100
KIMQDPIQQG EGLYCNRTWD GWLCWNDVAA GTESMQYCPD YFQDFDPSEK
110 120 130 140 150
VTKICDQDGN WFRHPDSNRT WTNYTLCNNS THEKVKTALN LFYLTIIGHG
160 170 180 190 200
LSIASLIISL IIFFYFKSLS CQRITLHKNL FFSFVCNSIV TIIHLTAVAN
210 220 230 240 250
NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ
260 270 280 290 300
HLMWYYFLGW GFPLLPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
310 320 330 340 350
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV
360 370 380 390 400
LFPWRPEGKV AEEVYDYVMH ILMHYQGLLV STIFCFFNGE VQAILRRNWN
410 420 430 440 450
QYKIQFGNGF SHSDALRSAS YTVSTISDVQ GYSHDCPTEH LNGKSIQDIE
460
NVALKPEKMY DLVM
Length:464
Mass (Da):53,329
Last modified:November 1, 1997 - v1
Checksum:i7373EC94B0FBC33C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70658 mRNA. Translation: CAA49997.1.
PIRiI60194.
RefSeqiNP_036849.1. NM_012717.1.
XP_006234500.1. XM_006234438.2.
XP_006234501.1. XM_006234439.2.
UniGeneiRn.11202.

Genome annotation databases

EnsembliENSRNOT00000006462; ENSRNOP00000006462; ENSRNOG00000004622.
GeneIDi25029.
KEGGirno:25029.
UCSCiRGD:2255. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70658 mRNA. Translation: CAA49997.1 .
PIRi I60194.
RefSeqi NP_036849.1. NM_012717.1.
XP_006234500.1. XM_006234438.2.
XP_006234501.1. XM_006234439.2.
UniGenei Rn.11202.

3D structure databases

ProteinModelPortali Q63118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1504930.
STRINGi 10116.ENSRNOP00000006462.

Chemistry

BindingDBi Q63118.
ChEMBLi CHEMBL4755.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q63118.

Proteomic databases

PRIDEi Q63118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006462 ; ENSRNOP00000006462 ; ENSRNOG00000004622 .
GeneIDi 25029.
KEGGi rno:25029.
UCSCi RGD:2255. rat.

Organism-specific databases

CTDi 10203.
RGDi 2255. Calcrl.

Phylogenomic databases

eggNOGi NOG255868.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000230695.
HOVERGENi HBG102129.
InParanoidi Q63118.
KOi K04577.
OMAi LCWNDVA.
OrthoDBi EOG712TW2.
PhylomeDBi Q63118.
TreeFami TF315710.

Miscellaneous databases

NextBioi 605171.
PROi Q63118.

Gene expression databases

Genevestigatori Q63118.

Family and domain databases

InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A new calcitonin-receptor-like sequence in rat pulmonary blood vessels."
    Njuki F., Nicholl C.G., Howard A., Mak J.C., Barnes P.J., Girgis S.I., Legon S.
    Clin. Sci. 85:385-388(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Lung.

Entry informationi

Entry nameiCALRL_RAT
AccessioniPrimary (citable) accession number: Q63118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3