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Q63118

- CALRL_RAT

UniProt

Q63118 - CALRL_RAT

Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.By similarity

    GO - Molecular functioni

    1. adrenomedullin receptor activity Source: Ensembl
    2. calcitonin gene-related peptide receptor activity Source: Ensembl
    3. calcitonin receptor activity Source: RGD
    4. protein transporter activity Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. angiogenesis Source: Ensembl
    3. calcium ion transport Source: Ensembl
    4. cAMP biosynthetic process Source: Ensembl
    5. cellular response to sucrose stimulus Source: Ensembl
    6. heart development Source: Ensembl
    7. negative regulation of inflammatory response Source: RGD
    8. positive regulation of cAMP biosynthetic process Source: Ensembl
    9. positive regulation of smooth muscle cell proliferation Source: Ensembl
    10. receptor internalization Source: Ensembl
    11. regulation of muscle contraction Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin gene-related peptide type 1 receptor
    Short name:
    CGRP type 1 receptor
    Alternative name(s):
    Calcitonin receptor-like receptor
    Gene namesi
    Name:Calcrl
    Synonyms:Cgrpr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi2255. Calcrl.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. endosome Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. lysosome Source: Ensembl
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 464441Calcitonin gene-related peptide type 1 receptorPRO_0000012813Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi48 ↔ 74By similarity
    Disulfide bondi65 ↔ 105By similarity
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi88 ↔ 127By similarity
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ63118.

    PTM databases

    PhosphoSiteiQ63118.

    Expressioni

    Gene expression databases

    GenevestigatoriQ63118.

    Interactioni

    Subunit structurei

    Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.By similarity

    Protein-protein interaction databases

    MINTiMINT-1504930.
    STRINGi10116.ENSRNOP00000006462.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63118.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 146123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini167 – 1737CytoplasmicSequence Analysis
    Topological domaini194 – 21320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini237 – 25317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28916ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini314 – 33623CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini355 – 36612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini389 – 46476CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei147 – 16620Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei174 – 19320Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei214 – 23623Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27320Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31324Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei337 – 35418Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei367 – 38822Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG255868.
    GeneTreeiENSGT00750000117654.
    HOGENOMiHOG000230695.
    HOVERGENiHBG102129.
    InParanoidiQ63118.
    KOiK04577.
    OMAiLCWNDVA.
    OrthoDBiEOG712TW2.
    PhylomeDBiQ63118.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR003289. GPCR_2_CGRP1_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01351. CGRPRECEPTOR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q63118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMDKKCTLCF LFLLLLNMAL IAAESEEGAN QTDLGVTRNK IMTAQYECYQ    50
    KIMQDPIQQG EGLYCNRTWD GWLCWNDVAA GTESMQYCPD YFQDFDPSEK 100
    VTKICDQDGN WFRHPDSNRT WTNYTLCNNS THEKVKTALN LFYLTIIGHG 150
    LSIASLIISL IIFFYFKSLS CQRITLHKNL FFSFVCNSIV TIIHLTAVAN 200
    NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ 250
    HLMWYYFLGW GFPLLPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA 300
    ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV 350
    LFPWRPEGKV AEEVYDYVMH ILMHYQGLLV STIFCFFNGE VQAILRRNWN 400
    QYKIQFGNGF SHSDALRSAS YTVSTISDVQ GYSHDCPTEH LNGKSIQDIE 450
    NVALKPEKMY DLVM 464
    Length:464
    Mass (Da):53,329
    Last modified:November 1, 1997 - v1
    Checksum:i7373EC94B0FBC33C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70658 mRNA. Translation: CAA49997.1.
    PIRiI60194.
    RefSeqiNP_036849.1. NM_012717.1.
    XP_006234500.1. XM_006234438.1.
    XP_006234501.1. XM_006234439.1.
    UniGeneiRn.11202.

    Genome annotation databases

    EnsembliENSRNOT00000006462; ENSRNOP00000006462; ENSRNOG00000004622.
    GeneIDi25029.
    KEGGirno:25029.
    UCSCiRGD:2255. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70658 mRNA. Translation: CAA49997.1 .
    PIRi I60194.
    RefSeqi NP_036849.1. NM_012717.1.
    XP_006234500.1. XM_006234438.1.
    XP_006234501.1. XM_006234439.1.
    UniGenei Rn.11202.

    3D structure databases

    ProteinModelPortali Q63118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1504930.
    STRINGi 10116.ENSRNOP00000006462.

    Chemistry

    BindingDBi Q63118.
    ChEMBLi CHEMBL2109240.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q63118.

    Proteomic databases

    PRIDEi Q63118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006462 ; ENSRNOP00000006462 ; ENSRNOG00000004622 .
    GeneIDi 25029.
    KEGGi rno:25029.
    UCSCi RGD:2255. rat.

    Organism-specific databases

    CTDi 10203.
    RGDi 2255. Calcrl.

    Phylogenomic databases

    eggNOGi NOG255868.
    GeneTreei ENSGT00750000117654.
    HOGENOMi HOG000230695.
    HOVERGENi HBG102129.
    InParanoidi Q63118.
    KOi K04577.
    OMAi LCWNDVA.
    OrthoDBi EOG712TW2.
    PhylomeDBi Q63118.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 605171.
    PROi Q63118.

    Gene expression databases

    Genevestigatori Q63118.

    Family and domain databases

    InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR003289. GPCR_2_CGRP1_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01351. CGRPRECEPTOR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new calcitonin-receptor-like sequence in rat pulmonary blood vessels."
      Njuki F., Nicholl C.G., Howard A., Mak J.C., Barnes P.J., Girgis S.I., Legon S.
      Clin. Sci. 85:385-388(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Lung.

    Entry informationi

    Entry nameiCALRL_RAT
    AccessioniPrimary (citable) accession number: Q63118
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3