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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.By similarity

GO - Molecular functioni

  1. adrenomedullin receptor activity Source: Ensembl
  2. calcitonin gene-related peptide receptor activity Source: Ensembl
  3. calcitonin receptor activity Source: InterPro
  4. protein transporter activity Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. angiogenesis Source: Ensembl
  3. calcium ion transport Source: Ensembl
  4. cAMP biosynthetic process Source: Ensembl
  5. cellular response to sucrose stimulus Source: Ensembl
  6. heart development Source: Ensembl
  7. negative regulation of inflammatory response Source: RGD
  8. negative regulation of smooth muscle contraction Source: RGD
  9. positive regulation of cAMP biosynthetic process Source: Ensembl
  10. positive regulation of smooth muscle cell proliferation Source: Ensembl
  11. receptor internalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_322710. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Cgrpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2255. Calcrl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 146123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei147 – 16620Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini167 – 1737CytoplasmicSequence Analysis
Transmembranei174 – 19320Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini194 – 21320ExtracellularSequence AnalysisAdd
BLAST
Transmembranei214 – 23623Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini237 – 25317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei254 – 27320Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini274 – 28916ExtracellularSequence AnalysisAdd
BLAST
Transmembranei290 – 31324Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini314 – 33623CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei337 – 35418Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini355 – 36612ExtracellularSequence AnalysisAdd
BLAST
Transmembranei367 – 38822Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini389 – 46476CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. endosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosome Source: Ensembl
  5. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 464441Calcitonin gene-related peptide type 1 receptorPRO_0000012813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi48 ↔ 74By similarity
Disulfide bondi65 ↔ 105By similarity
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi88 ↔ 127By similarity
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ63118.

PTM databases

PhosphoSiteiQ63118.

Expressioni

Gene expression databases

GenevestigatoriQ63118.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.By similarity

Protein-protein interaction databases

MINTiMINT-1504930.
STRINGi10116.ENSRNOP00000006462.

Structurei

3D structure databases

ProteinModelPortaliQ63118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ63118.
KOiK04577.
OMAiLCWNDVA.
OrthoDBiEOG712TW2.
PhylomeDBiQ63118.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDKKCTLCF LFLLLLNMAL IAAESEEGAN QTDLGVTRNK IMTAQYECYQ
60 70 80 90 100
KIMQDPIQQG EGLYCNRTWD GWLCWNDVAA GTESMQYCPD YFQDFDPSEK
110 120 130 140 150
VTKICDQDGN WFRHPDSNRT WTNYTLCNNS THEKVKTALN LFYLTIIGHG
160 170 180 190 200
LSIASLIISL IIFFYFKSLS CQRITLHKNL FFSFVCNSIV TIIHLTAVAN
210 220 230 240 250
NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ
260 270 280 290 300
HLMWYYFLGW GFPLLPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
310 320 330 340 350
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV
360 370 380 390 400
LFPWRPEGKV AEEVYDYVMH ILMHYQGLLV STIFCFFNGE VQAILRRNWN
410 420 430 440 450
QYKIQFGNGF SHSDALRSAS YTVSTISDVQ GYSHDCPTEH LNGKSIQDIE
460
NVALKPEKMY DLVM
Length:464
Mass (Da):53,329
Last modified:October 31, 1997 - v1
Checksum:i7373EC94B0FBC33C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70658 mRNA. Translation: CAA49997.1.
PIRiI60194.
RefSeqiNP_036849.1. NM_012717.1.
XP_006234500.1. XM_006234438.2.
XP_006234501.1. XM_006234439.2.
UniGeneiRn.11202.

Genome annotation databases

EnsembliENSRNOT00000006462; ENSRNOP00000006462; ENSRNOG00000004622.
GeneIDi25029.
KEGGirno:25029.
UCSCiRGD:2255. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70658 mRNA. Translation: CAA49997.1.
PIRiI60194.
RefSeqiNP_036849.1. NM_012717.1.
XP_006234500.1. XM_006234438.2.
XP_006234501.1. XM_006234439.2.
UniGeneiRn.11202.

3D structure databases

ProteinModelPortaliQ63118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1504930.
STRINGi10116.ENSRNOP00000006462.

Chemistry

BindingDBiQ63118.
ChEMBLiCHEMBL4755.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ63118.

Proteomic databases

PRIDEiQ63118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006462; ENSRNOP00000006462; ENSRNOG00000004622.
GeneIDi25029.
KEGGirno:25029.
UCSCiRGD:2255. rat.

Organism-specific databases

CTDi10203.
RGDi2255. Calcrl.

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ63118.
KOiK04577.
OMAiLCWNDVA.
OrthoDBiEOG712TW2.
PhylomeDBiQ63118.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_322710. Calcitonin-like ligand receptors.

Miscellaneous databases

NextBioi605171.
PROiQ63118.

Gene expression databases

GenevestigatoriQ63118.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A new calcitonin-receptor-like sequence in rat pulmonary blood vessels."
    Njuki F., Nicholl C.G., Howard A., Mak J.C., Barnes P.J., Girgis S.I., Legon S.
    Clin. Sci. 85:385-388(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Lung.

Entry informationi

Entry nameiCALRL_RAT
AccessioniPrimary (citable) accession number: Q63118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: March 31, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.