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Protein

Calcitonin gene-related peptide type 1 receptor

Gene

Calcrl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide type 1 receptor
Short name:
CGRP type 1 receptor
Alternative name(s):
Calcitonin receptor-like receptor
Gene namesi
Name:Calcrl
Synonyms:Cgrpr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2255. Calcrl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 146ExtracellularSequence analysisAdd BLAST123
Transmembranei147 – 166Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini167 – 173CytoplasmicSequence analysis7
Transmembranei174 – 193Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini194 – 213ExtracellularSequence analysisAdd BLAST20
Transmembranei214 – 236Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini237 – 253CytoplasmicSequence analysisAdd BLAST17
Transmembranei254 – 273Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini274 – 289ExtracellularSequence analysisAdd BLAST16
Transmembranei290 – 313Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini314 – 336CytoplasmicSequence analysisAdd BLAST23
Transmembranei337 – 354Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini355 – 366ExtracellularSequence analysisAdd BLAST12
Transmembranei367 – 388Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini389 – 464CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001281324 – 464Calcitonin gene-related peptide type 1 receptorAdd BLAST441

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi48 ↔ 74By similarity
Disulfide bondi65 ↔ 105By similarity
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi88 ↔ 127By similarity
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Modified residuei420PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63118.
PRIDEiQ63118.

PTM databases

iPTMnetiQ63118.
PhosphoSitePlusiQ63118.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004622.
GenevisibleiQ63118. RN.

Interactioni

Subunit structurei

Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.By similarity

Protein-protein interaction databases

MINTiMINT-1504930.
STRINGi10116.ENSRNOP00000006462.

Chemistry databases

BindingDBiQ63118.

Structurei

3D structure databases

ProteinModelPortaliQ63118.
SMRiQ63118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ63118.
KOiK04577.
OMAiIVTAQFE.
OrthoDBiEOG091G027C.
PhylomeDBiQ63118.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDKKCTLCF LFLLLLNMAL IAAESEEGAN QTDLGVTRNK IMTAQYECYQ
60 70 80 90 100
KIMQDPIQQG EGLYCNRTWD GWLCWNDVAA GTESMQYCPD YFQDFDPSEK
110 120 130 140 150
VTKICDQDGN WFRHPDSNRT WTNYTLCNNS THEKVKTALN LFYLTIIGHG
160 170 180 190 200
LSIASLIISL IIFFYFKSLS CQRITLHKNL FFSFVCNSIV TIIHLTAVAN
210 220 230 240 250
NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ
260 270 280 290 300
HLMWYYFLGW GFPLLPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA
310 320 330 340 350
ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV
360 370 380 390 400
LFPWRPEGKV AEEVYDYVMH ILMHYQGLLV STIFCFFNGE VQAILRRNWN
410 420 430 440 450
QYKIQFGNGF SHSDALRSAS YTVSTISDVQ GYSHDCPTEH LNGKSIQDIE
460
NVALKPEKMY DLVM
Length:464
Mass (Da):53,329
Last modified:November 1, 1997 - v1
Checksum:i7373EC94B0FBC33C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70658 mRNA. Translation: CAA49997.1.
PIRiI60194.
RefSeqiNP_036849.1. NM_012717.1.
XP_006234500.1. XM_006234438.3.
XP_006234501.1. XM_006234439.3.
UniGeneiRn.11202.

Genome annotation databases

EnsembliENSRNOT00000078645; ENSRNOP00000074452; ENSRNOG00000054695.
ENSRNOT00000088170; ENSRNOP00000070720; ENSRNOG00000054695.
GeneIDi25029.
KEGGirno:25029.
UCSCiRGD:2255. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70658 mRNA. Translation: CAA49997.1.
PIRiI60194.
RefSeqiNP_036849.1. NM_012717.1.
XP_006234500.1. XM_006234438.3.
XP_006234501.1. XM_006234439.3.
UniGeneiRn.11202.

3D structure databases

ProteinModelPortaliQ63118.
SMRiQ63118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1504930.
STRINGi10116.ENSRNOP00000006462.

Chemistry databases

BindingDBiQ63118.
ChEMBLiCHEMBL4755.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ63118.
PhosphoSitePlusiQ63118.

Proteomic databases

PaxDbiQ63118.
PRIDEiQ63118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000078645; ENSRNOP00000074452; ENSRNOG00000054695.
ENSRNOT00000088170; ENSRNOP00000070720; ENSRNOG00000054695.
GeneIDi25029.
KEGGirno:25029.
UCSCiRGD:2255. rat.

Organism-specific databases

CTDi10203.
RGDi2255. Calcrl.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ63118.
KOiK04577.
OMAiIVTAQFE.
OrthoDBiEOG091G027C.
PhylomeDBiQ63118.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ63118.

Gene expression databases

BgeeiENSRNOG00000004622.
GenevisibleiQ63118. RN.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR003289. GPCR_2_CGRP1_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01351. CGRPRECEPTOR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALRL_RAT
AccessioniPrimary (citable) accession number: Q63118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.