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Reviewed, UniProtKB/Swiss-Prot Q63117 (CLK3_RAT)

Last modified October 13, 2009. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dual specificity protein kinase CLK3
    EC=2.7.12.1
Alternative name(s):
    CDC-like kinase 3
Gene names
Name: Clk3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesiclesecretory vesicleacrosome By similarity.

Post-translational modification

Autophosphorylates on all three types of residues.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Dual specificity protein kinase CLK3
PRO_0000085872

Regions

Domain156 – 472317Protein kinase
Nucleotide binding162 – 1709ATP By similarity

Sites

Active site2831Proton acceptor By similarity
Binding site1861ATP By similarity

Amino acid modifications

Modified residue71Phosphotyrosine By similarity
Modified residue91Phosphoserine By similarity
Modified residue491Phosphoserine By similarity
Modified residue511Phosphoserine By similarity
Modified residue671Phosphoserine By similarity
Modified residue761Phosphoserine By similarity
Modified residue781Phosphoserine By similarity
Modified residue1351Phosphoserine By similarity

Experimental info

Sequence conflict4581A → S in CAA64076. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q63117-1 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: 6B10CA96A64AB19A

FASTA49058,485
        10         20         30         40         50         60 
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR SHDRIPYQRR 

        70         80         90        100        110        120 
YREHRDSDTY RCEERSPSFG EDCYGSSRSR HRRRSRERGP YRTRKHAHHC HKRRTRSCSS 

       130        140        150        160        170        180 
ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD WLQERYEIVG NLGEGTFGKV VECLDHARGK 

       190        200        210        220        230        240 
SQVALKIIRN VGKYREAARL EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG 

       250        260        270        280        290        300 
KNTFEFLKEN NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY 

       310        320        330        340        350        360 
NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG WAQPCDVWSI 

       370        380        390        400        410        420 
GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR TRKQKYFYKG GLVWDENSSD 

       430        440        450        460        470        480 
GRYVKENCKP LKSYMLQDSL EHVQLFDLMR RMLEFDPAQR ITLAEALLHP FFAGLTPEER 

       490 
SFHSSRNPSR 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and characterization of rat Clk3, a LAMMER kinase predominately expressed in testis."
Becker W., Kentrup H., Heukelbach J., Joost H.G.
Biochim. Biophys. Acta 1312:63-67(1996) [PubMed: 8679717] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

X94351 mRNA. Translation: CAA64076.1.
BC070891 mRNA. Translation: AAH70891.1.
IPIIPI00205776.
PIRS70352.
RefSeqNP_599167.1.
UniGeneRn.10340

3D structure databases

HSSPHSSP built from PDB template 1BI8 based on UniProtKB Q00534.
SMRQ63117. Positions 136-481.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ63117.

PTM databases

PhosphoSiteQ63117.

Genome annotation databases

EnsemblENSRNOT00000049440; ENSRNOP00000042962; ENSRNOG00000030126; Rattus norvegicus. [Genome view]
GeneID171305.
KEGGrno:171305.
UCSCNM_134340. rat.

Organism-specific databases

CTD171305.
RGD621259. Clk3.

Phylogenomic databases

HOVERGENQ63117.

Enzyme and pathway databases

BRENDA2.7.12.1. 248.

Gene expression databases

ArrayExpressQ63117.
GenevestigatorQ63117.
GermOnlineENSRNOG00000030126. Rattus norvegicus.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio622075.

Entry information

Entry nameCLK3_RAT
AccessionPrimary (citable) accession number: Q63117
Secondary accession number(s): Q6IRK2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 12, 2007
Last modified: October 13, 2009
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents