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Protein
Submitted name:

C-kit receptor tyrosine kinase

Gene

Kit

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi570MagnesiumUniRule annotation1
Binding sitei625ATPUniRule annotation1
Binding sitei797ATPUniRule annotation1
Metal bindingi798MagnesiumUniRule annotation1
Metal bindingi811MagnesiumUniRule annotation1
Sitei937Important for interaction with phosphotyrosine-binding proteinsUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi598 – 605ATPUniRule annotation8
Nucleotide bindingi673 – 679ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-1433557. Signaling by SCF-KIT.
R-RNO-1433559. Regulation of KIT signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
C-kit receptor tyrosine kinaseImported
Submitted name:
KIT proto-oncogene receptor tyrosine kinaseImported
Submitted name:
Kit oncogeneImported
Submitted name:
V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, isoform CRA_aImported
Gene namesi
Name:KitImported
Synonyms:KITImported
ORF Names:rCG_56893Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620568. Kit.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei523 – 550HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501121008526 – 978Sequence analysisAdd BLAST953

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000002227.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003050.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 97Ig-likeInterPro annotationAdd BLAST61
Domaini212 – 310Ig-likeInterPro annotationAdd BLAST99
Domaini591 – 938Protein kinaseInterPro annotationAdd BLAST348

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
HOGENOMiHOG000112008.
HOVERGENiHBG004335.
KOiK05091.
OMAiPTFKQIV.
OrthoDBiEOG091G01TL.
TreeFamiTF325768.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR027263. SCGF_receptor.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001824. Tyr_kinase_rcpt_3_CS.
PfamiView protein in Pfam
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF500951. SCGF_recepter. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGARGAWDL LCVLLVLLRG QTGTSQPSAS PGEPSPPSIQ PAQSELIVEA
60 70 80 90 100
GDTIRLTCTD PAFVKWTFEI LDVRIENKQS EWIREKAEAT HTGKYTCVSG
110 120 130 140 150
SGLRSSIYVF VRDPAVLFLV GLPLFGKEDN DALVRCPLTD PQVSNYSLIE
160 170 180 190 200
CDGKSLPTDL KFVPNPKAGI TIKNVKRAYH RLCIRCAAQR EGKWMRSDKF
210 220 230 240 250
TLKVRAAIKA IPVVSVPETS HLLKEGDTFT VICTIKDVST SVDSMWIKLN
260 270 280 290 300
PQPQSKAQVK RNSWHQGDFN YERQETLTIS SARVNDSGVF MCYANNTFGS
310 320 330 340 350
ANVTTTLKVV EKGFINIFPV KNTTVFVTDG ENVDLVVEFE AYPKPEHQQW
360 370 380 390 400
IYMNRTPTNR GEDYVKSDNQ SNIRYVNELR LTRLKGTEGG TYTFLVSNSD
410 420 430 440 450
VSASVTFDVY VNTKPEILTY DRLMNGRLQC VAAGFPEPTI DWYFCTGAEQ
460 470 480 490 500
RCTVPVPPVD VQIQNASVSP FGKLVVQSSI DSSVFRHNGT VECKASNAVG
510 520 530 540 550
KSSAFFNFAF KGNSKEQIQP HTLFTPLLIG FVVTAGLMGI IVMVLAYKYL
560 570 580 590 600
QKPMYEVQWK VVEEINGNNY VYIDPTQLPY DHKWEFPRNR LSFGKTLGAG
610 620 630 640 650
AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG
660 670 680 690 700
NHMNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FIFSKQEEQA
710 720 730 740 750
DAALYKNLLH SKESSCDSSN EYMDMKPGVS YVVPTKTDKR RSARIDSYIE
760 770 780 790 800
RDVTPAIMED DELALDLEDL LSFSYQVAKG MAFLASKNCI HRDLAARNIL
810 820 830 840 850
LTHGRITKIC DFGLARDIRN DSNYVVKGNA RLPVKWMAPE SIFNCVYTFE
860 870 880 890 900
SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM LSPEHAPAAM
910 920 930 940 950
YEVMKTCWDA DPLKRPTFKQ VVQLIEKQIS DSSKHIYSNL ANCNPNPENP
960 970
VVVDHSVRVN SVGSSTSSTQ PLLVHEDA
Length:978
Mass (Da):109,342
Last modified:November 1, 1996 - v1
Checksum:i0958C33F19889051
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014877 Genomic DNA. No translation available.
AABR07014878 Genomic DNA. No translation available.
AABR07014879 Genomic DNA. No translation available.
EU247827 mRNA. Translation: ABX45067.1.
EU247828 mRNA. Translation: ABX45068.1.
D12524 mRNA. Translation: BAA02094.1.
CH473981 Genomic DNA. Translation: EDL89921.1.
PIRiA49814.
RefSeqiNP_071600.1. NM_022264.1.
UniGeneiRn.54004.

Genome annotation databases

EnsembliENSRNOT00000003050; ENSRNOP00000003050; ENSRNOG00000002227.
GeneIDi64030.
KEGGirno:64030.

Similar proteinsi

Entry informationi

Entry nameiQ63116_RAT
AccessioniPrimary (citable) accession number: Q63116
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported