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Protein

FXYD domain-containing ion transport regulator 4

Gene

Fxyd4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Induces a potassium channel when expressed in Xenopus oocytes.

GO - Molecular functioni

  • potassium channel activity Source: RGD
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi1.A.27.1.4. the phospholemman (plm) family.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 4
Alternative name(s):
Channel-inducing factor
Short name:
CHIF
Corticosteroid-induced protein
Gene namesi
Name:Fxyd4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi70998. Fxyd4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 38ExtracellularSequence analysisAdd BLAST18
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 87CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001036821 – 87FXYD domain-containing ion transport regulator 4Add BLAST67

Proteomic databases

PaxDbiQ63113.
PRIDEiQ63113.

Expressioni

Tissue specificityi

Selectively present in the distal parts of the nephron (medullary and papillary collecting ducts and end portions of cortical collecting tubule) and in the epithelial cells of the distal colon. No expression is found in renal proximal tubule, loop of henle and distal tubule, proximal colon, small intestine, lung, choroid plexus, salivary glands, or brain.1 Publication

Inductioni

By corticosteroids.

Gene expression databases

BgeeiENSRNOG00000014578.
GenevisibleiQ63113. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019649.

Structurei

Secondary structure

187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 34Combined sources6
Helixi35 – 57Combined sources23
Helixi60 – 65Combined sources6
Turni69 – 71Combined sources3
Turni73 – 75Combined sources3
Helixi77 – 80Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JP3NMR-A21-87[»]
ProteinModelPortaliQ63113.
SMRiQ63113.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ63113.

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ63113.
KOiK13359.
OMAiPGSASTC.
OrthoDBiEOG091G17M7.
PhylomeDBiQ63113.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63113-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGITCAFLL VLAGLPVLEA NGPVDKGSPF YYDWESLQLG GMIFGGLLCI
60 70 80
AGIAMALSGK CKCRRNHTPS SLPEKVTPLI TPGSAST
Length:87
Mass (Da):9,084
Last modified:November 1, 1996 - v1
Checksum:i5D0DE1FFC6B1BCCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41254 mRNA. Translation: AAA74691.1.
PIRiI59391.
RefSeqiNP_071783.1. NM_022388.1.
XP_006237268.1. XM_006237206.2.
XP_017448357.1. XM_017592868.1.
UniGeneiRn.105.

Genome annotation databases

EnsembliENSRNOT00000019649; ENSRNOP00000019649; ENSRNOG00000014578.
GeneIDi64190.
KEGGirno:64190.
UCSCiRGD:70998. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41254 mRNA. Translation: AAA74691.1.
PIRiI59391.
RefSeqiNP_071783.1. NM_022388.1.
XP_006237268.1. XM_006237206.2.
XP_017448357.1. XM_017592868.1.
UniGeneiRn.105.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JP3NMR-A21-87[»]
ProteinModelPortaliQ63113.
SMRiQ63113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019649.

Protein family/group databases

TCDBi1.A.27.1.4. the phospholemman (plm) family.

Proteomic databases

PaxDbiQ63113.
PRIDEiQ63113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019649; ENSRNOP00000019649; ENSRNOG00000014578.
GeneIDi64190.
KEGGirno:64190.
UCSCiRGD:70998. rat.

Organism-specific databases

CTDi53828.
RGDi70998. Fxyd4.

Phylogenomic databases

eggNOGiENOG410J4PQ. Eukaryota.
ENOG4111AWX. LUCA.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ63113.
KOiK13359.
OMAiPGSASTC.
OrthoDBiEOG091G17M7.
PhylomeDBiQ63113.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.

Miscellaneous databases

EvolutionaryTraceiQ63113.
PROiQ63113.

Gene expression databases

BgeeiENSRNOG00000014578.
GenevisibleiQ63113. RN.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXYD4_RAT
AccessioniPrimary (citable) accession number: Q63113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.