Q63113 (FXYD4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FXYD domain-containing ion transport regulator 4

Alternative name(s):
Channel-inducing factor
Short name=CHIF
Corticosteroid-induced protein

Gene names

Name:

Fxyd4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces a potassium channel when expressed in Xenopus oocytes.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Selectively present in the distal parts of the nephron (medullary and papillary collecting ducts and end portions of cortical collecting tubule) and in the epithelial cells of the distal colon. No expression is found in renal proximal tubule, loop of henle and distal tubule, proximal colon, small intestine, lung, choroid plexus, salivary glands, or brain. Ref.2
Induction	By corticosteroids.
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	potassium channel activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

20

Potential

Chain

21 – 87

67

FXYD domain-containing ion transport regulator 4

PRO_0000010368

Regions

Topological domain

21 – 38

18

Extracellular Potential

Transmembrane

39 – 59

21

Helical; Potential

Topological domain

60 – 87

28

Cytoplasmic Potential

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

87

Helix Strand Turn

Details...

Helix

29 – 34

6

Helix

35 – 57

23

Helix

60 – 65

6

Turn

69 – 71

3

Turn

73 – 75

3

Helix

77 – 80

4

Sequences

	Sequence		Length	Mass (Da)
	Q63113 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5D0DE1FFC6B1BCCA	FASTA	87	9,084
	10 20 30 40 50 60 MEGITCAFLL VLAGLPVLEA NGPVDKGSPF YYDWESLQLG GMIFGGLLCI AGIAMALSGK 70 80 CKCRRNHTPS SLPEKVTPLI TPGSAST

References

[1]	"A corticosteroid-induced gene expressing an 'IsK-like' K+ channel activity in Xenopus oocytes." Attali B., Latter H., Rachamim N., Garty H. Proc. Natl. Acad. Sci. U.S.A. 92:6092-6096(1995) [PubMed: 7597086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Colon.
[2]	"Cellular localization and regulation of CHIF in kidney and colon." Capurro C., Coutry N., Bonvalet J.-P., Escoubet B., Garty H., Farman N. Am. J. Physiol. 271:C753-C762(1996) [PubMed: 8843704] [Abstract] Cited for: TISSUE SPECIFICITY.
[3]	"Structural similarity of a membrane protein in micelles and membranes." Franzin C.M., Teriete P., Marassi F.M. J. Am. Chem. Soc. 129:8078-8079(2007) [PubMed: 17567018] [Abstract] Cited for: STRUCTURE BY NMR OF 21-87.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L41254 mRNA. Translation: AAA74691.1.

IPI

IPI00231458.

PIR

I59391.

RefSeq

NP_071783.1. NM_022388.1.

UniGene

Rn.105.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2JP3	NMR	-	A	21-87	[»]

ProteinModelPortal

Q63113.

SMR

Q63113. Positions 21-87.

ModBase

Search...

Protein-protein interaction databases

STRING

Q63113.

Protein family/group databases

TCDB

1.A.27.1.4. phospholemman (PLM) family.

Proteomic databases

PRIDE

Q63113.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000019649; ENSRNOP00000019649; ENSRNOG00000014578.

GeneID

64190.

KEGG

rno:64190.

UCSC

NM_022388. rat.

Organism-specific databases

CTD

53828.

RGD

70998. Fxyd4.

Phylogenomic databases

eggNOG

roNOG17752.

GeneTree

ENSGT00530000063998.

HOVERGEN

HBG008212.

InParanoid

Q63113.

OMA

AMALSGK.

OrthoDB

EOG4W0XFT.

PhylomeDB

Q63113.

Gene expression databases

ArrayExpress

Q63113.

Genevestigator

Q63113.

GermOnline

ENSRNOG00000014578. Rattus norvegicus.

Family and domain databases

InterPro

IPR000272. Ion-transport_regulator_FXYD.
[Graphical view]

KO

K13359.

Pfam

PF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]

ProDom

PD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]

PROSITE

PS01310. FXYD. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

612848.

Entry information

Entry name

FXYD4_RAT

Accession

Primary (citable) accession number: Q63113

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program