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Protein

Carboxylesterase 1E

Gene

Ces1e

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei353Charge relay systemBy similarity1
Active sitei466Charge relay systemBy similarity1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: RGD
  • palmitoyl-CoA hydrolase activity Source: RGD

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

BRENDAi3.1.1.1 5301

Protein family/group databases

ESTHERiratno-Ces1e Carb_B_Chordata

Chemistry databases

SwissLipidsiSLP:000001459

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylesterase 1E (EC:3.1.1.1)
Alternative name(s):
Carboxyesterase ES-3
ES-HTEL
Egasyn
Liver carboxylesterase 3
pI 5.5 esterase
Gene namesi
Name:Ces1e
Synonyms:Ces1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621508 Ces1e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2771

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000858019 – 561Carboxylesterase 1EAdd BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 116By similarity
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi273 ↔ 284By similarity
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ63108
PRIDEiQ63108

PTM databases

iPTMnetiQ63108
PhosphoSitePlusiQ63108

Structurei

3D structure databases

ProteinModelPortaliQ63108
SMRiQ63108
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi558 – 561Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000091866
HOVERGENiHBG008839
InParanoidiQ63108
PhylomeDBiQ63108

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLYALILVF LAAFTAGGHP SSLPVVDTLQ GKVLGKYVSL EGFTQPVAVF
60 70 80 90 100
LGVPFAKPPL GSLRFAPPQP AEPWSFVKNT TSYPPMCSQD PVAGQIVNDL
110 120 130 140 150
LTNWEENISL QFSEDCLYLN IYTPADLTKR DRLPVMVWIH GGGLVLGGAS
160 170 180 190 200
TYDGLALSTH ENVVVVVIQY RLGIWGFFST GDEHSRGNWG HLDQVAALHW
210 220 230 240 250
VQDNIDNFGG DPGSVTIFGE SAGGESVSVL VLSPLAKNLF HKAISESGVA
260 270 280 290 300
LTAGLVKKNT RPLAEKIAVV SGCKSTTSAS MVHCLRQKTE EELLETTLKL
310 320 330 340 350
NLFSLDLHGD SRQSYPFVPT VLDGVVLPKM PEEILAEKDF NTVPYIVGIN
360 370 380 390 400
KQEFGWILPT MMNYPPSDMK LDPMTATSLL KKSSFLLNLP EEAIPVAVEK
410 420 430 440 450
YLRHTDDPDR NKDQLLELIG DVIFGVPSVI VSRGHRDAGA RTYMYEFQYR
460 470 480 490 500
PSFSSKMKPS TVVGDHGDEI YSVFGAPILR GGTSKEEINL SKMMMKFWAN
510 520 530 540 550
FARNGNPNGQ GLPHWPEYDQ KEGYLQIGAT TQQAQKLKEK EVAFWSELLA
560
MKPLHAGHTE L
Length:561
Mass (Da):61,715
Last modified:November 1, 1996 - v1
Checksum:i1E14D66DF089B86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81395 mRNA Translation: CAA57158.1
PIRiJC2447
UniGeneiRn.161717

Similar proteinsi

Entry informationi

Entry nameiEST1E_RAT
AccessioniPrimary (citable) accession number: Q63108
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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