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Protein

CaM kinase-like vesicle-associated protein

Gene

Camkv

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has no detectable kinase activity in vitro.

Cofactori

Ca2+1 Publication

GO - Molecular functioni

  • ATP binding Source: InterPro
  • calmodulin binding Source: RGD
  • protein kinase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CaM kinase-like vesicle-associated protein
Alternative name(s):
1G5
Gene namesi
Name:Camkv
Synonyms:1G5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621488. Camkv.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002500961 – 504CaM kinase-like vesicle-associated proteinAdd BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei384PhosphoserineBy similarity1
Modified residuei438PhosphothreonineCombined sources1
Modified residuei462PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63092.
PRIDEiQ63092.

PTM databases

iPTMnetiQ63092.
PhosphoSitePlusiQ63092.
SwissPalmiQ63092.

Expressioni

Tissue specificityi

Expressed in brain and weakly in eye. Not detected in liver, kidney, spleen, thymus, bladder, aorta, lung, intestine, esophagus, stomach, skeletal muscle, heart, diaphragm, uterus, tail skin, submaxillary gland, prostate, ear, epididymis, placenta, pancreas, ovary, testis, adrenal gland, parathyroid gland, thyroid gland, pineal gland, pituitary and sciatic nerve. In adult hippocampus, predominantly expressed in caudate nucleus, cortex, hypothalamus, olfactory bulb, and midbrain and faintly in pons, brainstem and spinal cord.1 Publication

Developmental stagei

Expressed from day 16 dpc, but accumulation was primarily postnatal with maximal steady state levels reached at postnatal day 10.1 Publication

Interactioni

Subunit structurei

Interacts with calmodulin, in the presence of calcium.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: RGD

Protein-protein interaction databases

BioGridi249391. 1 interactor.
STRINGi10116.ENSRNOP00000025311.

Structurei

3D structure databases

ProteinModelPortaliQ63092.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 286Protein kinasePROSITE-ProRule annotationAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi335 – 482Ala-richAdd BLAST148

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ63092.
KOiK08812.
PhylomeDBiQ63092.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63092-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFGCVTLGD KKNYNQPSEV TDRYDLGQVV KTEEFCEIFR AKDKTTGKLH
60 70 80 90 100
TCKKFQKRDG RKVRKAAKNE IGILKMVKHP NILQLVDVFV TRKEYFIFLE
110 120 130 140 150
LATGREVFDW ILDQGYYSER DTSNVVRQVL EAVAYLHSLK IVHRNLKLEN
160 170 180 190 200
LVYYNRLKNS KIVISDFHLA KLENGLIKEP CGTPEYLAPE VVGRQRYGRP
210 220 230 240 250
VDCWAIGVIM YILLSGNPPF YEEVEEDDYE NHDKNLFRKI LAGDYEFDSP
260 270 280 290 300
YWDDISQAAK DLVTRLMEVE QDQRITAEEA ISHEWISGNA ASDKNIKDGV
310 320 330 340 350
CAQIEKNFAR AKWKKAVRVT TLMKRLRAPE QSGTAATSDA ATPGAAGGAV
360 370 380 390 400
AAAAGGAAPA SGASATVGTG GDAGCAAKSD DMASADRSAT PATDGSATPA
410 420 430 440 450
TDGSVTPATD GSITPATDGS VTPATDRSAT PATDGRATPA TEESTVPAAQ
460 470 480 490 500
SSAAPAAKAA ATPEPAVAQP DSTALEGATG QAPPSSKGEE ATGCAQESQR

VETS
Length:504
Mass (Da):54,106
Last modified:November 1, 1996 - v1
Checksum:iDF31E414B213B54E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22557 mRNA. Translation: AAA16633.1.
PIRiI56542.
RefSeqiNP_076490.1. NM_024000.1.
UniGeneiRn.9958.

Genome annotation databases

GeneIDi79011.
KEGGirno:79011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22557 mRNA. Translation: AAA16633.1.
PIRiI56542.
RefSeqiNP_076490.1. NM_024000.1.
UniGeneiRn.9958.

3D structure databases

ProteinModelPortaliQ63092.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249391. 1 interactor.
STRINGi10116.ENSRNOP00000025311.

PTM databases

iPTMnetiQ63092.
PhosphoSitePlusiQ63092.
SwissPalmiQ63092.

Proteomic databases

PaxDbiQ63092.
PRIDEiQ63092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79011.
KEGGirno:79011.

Organism-specific databases

CTDi79012.
RGDi621488. Camkv.

Phylogenomic databases

eggNOGiKOG0032. Eukaryota.
ENOG410XRMJ. LUCA.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ63092.
KOiK08812.
PhylomeDBiQ63092.

Miscellaneous databases

PROiQ63092.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAMKV_RAT
AccessioniPrimary (citable) accession number: Q63092
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.