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Protein

Cardiotrophin-1

Gene

Ctf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

GO - Molecular functioni

  • cytokine activity Source: RGD
  • leukemia inhibitory factor receptor binding Source: RGD

GO - Biological processi

  • immune response Source: InterPro
  • leukemia inhibitory factor signaling pathway Source: RGD
  • nervous system development Source: RGD
  • neuron development Source: Ensembl
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotrophin-1
Short name:
CT-1
Gene namesi
Name:Ctf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2442. Ctf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Cardiotrophin-1PRO_0000058764Add
BLAST

Proteomic databases

PaxDbiQ63086.

Expressioni

Tissue specificityi

Expressed in the ventricle and atrium of adult rats. Also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Not detected in brain, colon, testis, spleen or thymus. Overexpressed in the ventricles in the case of hypertension and hypertrophy.

Gene expression databases

GenevisibleiQ63086. RN.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: RGD
  • leukemia inhibitory factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025646.

Structurei

3D structure databases

ProteinModelPortaliQ63086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IWMK. Eukaryota.
ENOG41119TK. LUCA.
GeneTreeiENSGT00510000049046.
HOGENOMiHOG000112040.
HOVERGENiHBG000455.
InParanoidiQ63086.
KOiK05422.
OMAiGLYREWV.
OrthoDBiEOG7VHSZW.
PhylomeDBiQ63086.
TreeFamiTF333266.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Q63086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQREGSLED HQTDSSFSFL PHLEAKIRQT HNLARLLTKY ADQLLEEYVQ
60 70 80 90 100
QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSALPAL
110 120 130 140 150
LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP
160 170 180 190 200
VPEPVATSAL FTSNSAAGVF SAKVLGLHVC GLYGEWVSRT EGDLGQLVPG

GVA
Length:203
Mass (Da):21,439
Last modified:November 1, 1996 - v1
Checksum:iDF8B921A2FA1C832
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78591 mRNA. Translation: BAA11427.1.
BC072690 mRNA. Translation: AAH72690.1.
PIRiJC4645.
RefSeqiNP_058825.1. NM_017129.1.
UniGeneiRn.10253.

Genome annotation databases

EnsembliENSRNOT00000025646; ENSRNOP00000025646; ENSRNOG00000018962.
GeneIDi29201.
KEGGirno:29201.
UCSCiRGD:2442. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78591 mRNA. Translation: BAA11427.1.
BC072690 mRNA. Translation: AAH72690.1.
PIRiJC4645.
RefSeqiNP_058825.1. NM_017129.1.
UniGeneiRn.10253.

3D structure databases

ProteinModelPortaliQ63086.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025646.

Proteomic databases

PaxDbiQ63086.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025646; ENSRNOP00000025646; ENSRNOG00000018962.
GeneIDi29201.
KEGGirno:29201.
UCSCiRGD:2442. rat.

Organism-specific databases

CTDi1489.
RGDi2442. Ctf1.

Phylogenomic databases

eggNOGiENOG410IWMK. Eukaryota.
ENOG41119TK. LUCA.
GeneTreeiENSGT00510000049046.
HOGENOMiHOG000112040.
HOVERGENiHBG000455.
InParanoidiQ63086.
KOiK05422.
OMAiGLYREWV.
OrthoDBiEOG7VHSZW.
PhylomeDBiQ63086.
TreeFamiTF333266.

Enzyme and pathway databases

ReactomeiR-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

NextBioi608350.
PROiQ63086.

Gene expression databases

GenevisibleiQ63086. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001581. Leukemia_IF/oncostatin.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
PfamiPF01291. LIF_OSM. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats."
    Ishikawa M., Saito Y., Miyamoto Y., Kuwahara K., Ogawa E., Nakagawa O., Harada M., Masuda I., Nakao K.
    Biochem. Biophys. Res. Commun. 219:377-381(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCTF1_RAT
AccessioniPrimary (citable) accession number: Q63086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.