Reviewed,
UniProtKB/Swiss-Prot Q63081 (PDIA6_RAT)
Last modified
February 9, 2010.
Version 83.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Protein disulfide-isomerase A6 EC=5.3.4.1 Alternative name(s): Protein disulfide isomerase P5 Calcium-binding protein 1 Short name=CaBP1 Thioredoxin domain-containing protein 7 | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 440 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Catalyzes the rearrangement of -S-S- bonds in proteins. |
| Subcellular location | Endoplasmic reticulum lumen By similarity. Melanosome By similarity. |
| Sequence similarities | Belongs to the protein disulfide isomerase family. Contains 2 thioredoxin domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum |
| Domain | Redox-active center Repeat Signal |
| Ligand | Calcium |
| Molecular function | Isomerase |
| PTM | Disulfide bond Phosphoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | cell redox homeostasis Inferred from electronic annotation. Source: InterPro protein folding Ref.2Traceable author statement. Source: RGD |
| Cellular component | ER-Golgi intermediate compartment Ref.2 Traceable author statement. Source: RGD endoplasmic reticulum lumenInferred from direct assay. Source: HGNC melanosomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Ref.2 Traceable author statement. Source: RGD protein disulfide isomerase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | By similarity | ||||||||
| Chain | 20 – 440 | 421 | Protein disulfide-isomerase A6 | PRO_0000034240 | |||||||
Regions | |||||||||||
| Domain | 21 – 133 | 113 | Thioredoxin 1 | ||||||||
| Domain | 151 – 287 | 137 | Thioredoxin 2 | ||||||||
| Motif | 437 – 440 | 4 | Prevents secretion from ER By similarity | ||||||||
| Compositional bias | 422 – 436 | 15 | Asp/Glu-rich (acidic) | ||||||||
Sites | |||||||||||
| Active site | 55 | 1 | Nucleophile By similarity | ||||||||
| Active site | 58 | 1 | Nucleophile By similarity | ||||||||
| Active site | 190 | 1 | Nucleophile By similarity | ||||||||
| Active site | 193 | 1 | Nucleophile By similarity | ||||||||
| Site | 56 | 1 | Contributes to redox potential value By similarity | ||||||||
| Site | 57 | 1 | Contributes to redox potential value By similarity | ||||||||
| Site | 118 | 1 | Lowers pKa of C-terminal Cys of first active site By similarity | ||||||||
| Site | 191 | 1 | Contributes to redox potential value By similarity | ||||||||
| Site | 192 | 1 | Contributes to redox potential value By similarity | ||||||||
| Site | 256 | 1 | Lowers pKa of C-terminal Cys of second active site By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 428 | 1 | Phosphoserine By similarity | ||||||||
| Disulfide bond | 55 ↔ 58 | Redox-active By similarity | |||||||||
| Disulfide bond | 190 ↔ 193 | Redox-active By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [2] | "CaBP1, a calcium binding protein of the thioredoxin family, is a resident KDEL protein of the ER and not of the intermediate compartment." Fuellekrug J., Soennichsen B., Wuensch U., Arseven K., Van P.N., Soeling H.-D., Mieskes G. J. Cell Sci. 107:2719-2727(1994) [PubMed: 7876340] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-440. Strain: Wistar. Tissue: Liver. |
| [3] | Lubec G., Afjehi-Sadat L., Kang S.U. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 119-132; 217-231 AND 314-322, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain and Spinal cord. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC082063 mRNA. Translation: AAH82063.1. Different initiation. X79328 mRNA. Translation: CAA55891.1. |
| IPI | IPI00365929. |
| PIR | S45038. |
| RefSeq | NP_001004442.1. |
| UniGene | Rn.2685 |
3D structure databases | |
| SMR | Q63081. Positions 18-263, 154-280. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q63081. |
Proteomic databases | |
| PRIDE | Q63081. |
Genome annotation databases | |
| GeneID | 286906. |
| KEGG | rno:286906. |
| UCSC | BC082063. rat. |
Organism-specific databases | |
| CTD | 286906. |
| RGD | 628688. Pdia6. |
Phylogenomic databases | |
| HOVERGEN | Q63081. |
Enzyme and pathway databases | |
| BRENDA | 5.3.4.1. 248. |
Gene expression databases | |
| Genevestigator | Q63081. |
Family and domain databases | |
| InterPro | IPR005788. Disulphide_isomerase. IPR017936. Thioredoxin-like. IPR012336. Thioredoxin-like_fold. IPR006662. Thioredoxin-like_subdom. IPR017937. Thioredoxin_CS. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits. |
| Pfam | PF00085. Thioredoxin. 2 hits. [Graphical view] |
| PRINTS | PR00421. THIOREDOXIN. |
| TIGRFAMs | TIGR01126. pdi_dom. 2 hits. |
| PROSITE | PS00014. ER_TARGET. 1 hit. PS00194. THIOREDOXIN_1. 2 hits. PS51352. THIOREDOXIN_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 625007. |
Entry information
| Entry name | PDIA6_RAT | ||||||||
| Accession | Primary (citable) accession number: Q63081 Secondary accession number(s): Q641Y3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


