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Protein

Protein BTG1

Gene

Btg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Anti-proliferative protein.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cell proliferation Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of endothelial cell differentiation Source: UniProtKB
  • positive regulation of fibroblast apoptotic process Source: UniProtKB
  • protein methylation Source: Ensembl
  • response to oxidative stress Source: RGD
  • response to peptide hormone Source: RGD
  • spermatid development Source: UniProtKB
  • spermatogenesis Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG1
Alternative name(s):
Anti-proliferative factor
B-cell translocation gene 1 protein
Gene namesi
Name:Btg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2224. Btg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Protein BTG1PRO_0000143802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591PhosphoserineBy similarity
Modified residuei161 – 1611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ63073.

Expressioni

Gene expression databases

GenevisibleiQ63073. RN.

Interactioni

Subunit structurei

Interacts with CNOT7 and CNOT8.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ63073. 1 interaction.
STRINGi10116.ENSRNOP00000005910.

Structurei

3D structure databases

ProteinModelPortaliQ63073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiQ63073.
KOiK14443.
OMAiGHVNDRQ.
OrthoDBiEOG72RN0S.
PhylomeDBiQ63073.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033330. BTG1.
[Graphical view]
PANTHERiPTHR22978:SF27. PTHR22978:SF27. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE
60 70 80 90 100
HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS
110 120 130 140 150
ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSSQNSTNV QMVDSRISCK
160 170
EELLLGRTSP SKNYNMMTVS G
Length:171
Mass (Da):19,195
Last modified:November 1, 1997 - v1
Checksum:iF4ED8BE09017EF25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26268 mRNA. Translation: AAA85779.1.
RefSeqiNP_058954.1. NM_017258.1.
UniGeneiRn.1000.

Genome annotation databases

EnsembliENSRNOT00000005910; ENSRNOP00000005910; ENSRNOG00000004284.
GeneIDi29618.
KEGGirno:29618.
UCSCiRGD:2224. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L26268 mRNA. Translation: AAA85779.1.
RefSeqiNP_058954.1. NM_017258.1.
UniGeneiRn.1000.

3D structure databases

ProteinModelPortaliQ63073.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ63073. 1 interaction.
STRINGi10116.ENSRNOP00000005910.

Proteomic databases

PaxDbiQ63073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005910; ENSRNOP00000005910; ENSRNOG00000004284.
GeneIDi29618.
KEGGirno:29618.
UCSCiRGD:2224. rat.

Organism-specific databases

CTDi694.
RGDi2224. Btg1.

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiQ63073.
KOiK14443.
OMAiGHVNDRQ.
OrthoDBiEOG72RN0S.
PhylomeDBiQ63073.
TreeFamiTF105272.

Miscellaneous databases

PROiQ63073.

Gene expression databases

GenevisibleiQ63073. RN.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR033330. BTG1.
[Graphical view]
PANTHERiPTHR22978:SF27. PTHR22978:SF27. 1 hit.
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Stage-specific expression of B cell translocation gene 1 in rat testis."
    Raburn D.J., Hamil K.G., Tsuruta J.K., O'Brien D.A., Hall S.H.
    Endocrinology 136:5769-5777(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Testis.

Entry informationi

Entry nameiBTG1_RAT
AccessioniPrimary (citable) accession number: Q63073
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.