Reviewed, UniProtKB/Swiss-Prot Q63072 (BST1_RAT)

Names and origin

Protein names

Recommended name:
    ADP-ribosyl cyclase 2
    EC=3.2.2.5
Alternative name(s):
    Cyclic ADP-ribose hydrolase 2
      Short name=cADPr hydrolase 2
    Bone marrow stromal antigen 1
      Short name=BST-1
    CD_antigen=CD157

Gene names

Name:

Bst1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
Catalytic activity	NAD+ + H2O = ADP-ribose + nicotinamide.
Subunit structure	Homodimer By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Pancreatic islets, kidney, spleen, heart, thymus, intestine and salivary gland.
Sequence similarities	Belongs to the ADP-ribosyl cyclase family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
Ligand	NAD
Molecular function	Hydrolase
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD+ nucleosidase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Chain	28 – 294	267	ADP-ribosyl cyclase 2		PRO_0000004036
	Propeptide	295 – 319	25	Potential		PRO_0000004037
Amino acid modifications
	Lipidation	294	1	GPI-anchor amidated serine Potential
	Glycosylation	67	1	N-linked (GlcNAc...) Potential
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Glycosylation	193	1	N-linked (GlcNAc...) Potential
	Disulfide bond	52 ↔ 68		By similarity
	Disulfide bond	84 ↔ 164		By similarity
	Disulfide bond	145 ↔ 158		By similarity
	Disulfide bond	239 ↔ 260		By similarity
	Disulfide bond	272 ↔ 281		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q63072-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 46831685DE2B2472	FASTA	319	35,131
	10 20 30 40 50 60 MAVQACALSL RLGLWMSLLL PVLPGAGARA AGARWSGEGT TPHLQSIFLG RCAEYTTLLS 70 80 90 100 110 120 LEPGNKNCTA IWEAFKVVLD KDPCSVLPSD YDLFINLSRH AIPRDKSLFW ENNHLLVMSY 130 140 150 160 170 180 AENTRRLMPL CDVLYGKVGD FLSWCRQENA SGLDYQSCPT AEDCENNAVD AYWKSASMQY 190 200 210 220 230 240 SRDSSGVINV MLNGSEPKGA YPTKGFFADF EIPYLQKDKI TRIEIWVMHE VGGPHVESCG 250 260 270 280 290 300 EGSVKILEDR LEALGFQHSC INDYPPVKFL MCVDHSTHPD CAMNSASASM WRESPALHAI 310 GDISLIISLL VALASSSQA

References

[1]

"Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1 (BST-1) from the islets of Langerhans." Furuya Y., Takasawa S., Yonekura H., Tanaka T., Takahara J., Okamoto H. Gene 165:329-330(1995) [PubMed: 8522202] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Pancreatic islet.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D49955 mRNA. Translation: BAA08710.1.
IPI	IPI00204984.
PIR	JC4390.
RefSeq	NP_110475.1.
UniGene	Rn.10728
3D structure databases
HSSP	HSSP built from PDB template 1ISI based on UniProtKB Q10588.
SMR	Q63072. Positions 35-283.
ModBase	Search...
Protein-protein interaction databases
STRING	Q63072.
Genome annotation databases
Ensembl	ENSRNOT00000004094; ENSRNOP00000004094; ENSRNOG00000003064; Rattus norvegicus. [Genome view]
GeneID	81506.
KEGG	rno:81506.
Organism-specific databases
CTD	81506.
RGD	620344. Bst1.
Phylogenomic databases
HOVERGEN	Q63072.
Enzyme and pathway databases
BRENDA	3.2.2.5. 248.
Gene expression databases
ArrayExpress	Q63072.
Genevestigator	Q63072.
GermOnline	ENSRNOG00000003064. Rattus norvegicus.
Family and domain databases
InterPro	IPR003193. ADP-ribosyl_cyclase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR10912. Rib_hydrolayse. 1 hit.
Pfam	PF02267. Rib_hydrolayse. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	614967.

Entry information

Entry name

BST1_RAT

Accession

Primary (citable) accession number: Q63072

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	October 13, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)