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Protein

Glycerol kinase

Gene

Gk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP.By similarity1 Publication

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (Gk)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201SubstrateBy similarity
Binding sitei24 – 241ATPBy similarity
Binding sitei94 – 941SubstrateBy similarity
Binding sitei148 – 1481SubstrateBy similarity
Binding sitei259 – 2591SubstrateBy similarity
Binding sitei281 – 2811ATPBy similarity
Binding sitei326 – 3261ATP; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi427 – 4315ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glycerol kinase activity Source: GO_Central
  • histone binding Source: RGD

GO - Biological processi

  • glycerol-3-phosphate biosynthetic process Source: GO_Central
  • glycerol catabolic process Source: UniProtKB-UniPathway
  • glycerol metabolic process Source: GO_Central
  • response to cold Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to organic substance Source: RGD
  • triglyceride metabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Short name:
GK
Short name:
Glycerokinase
Alternative name(s):
ATP-stimulated glucocorticoid-receptor translocation promoter
Short name:
ASTP
ATP:glycerol 3-phosphotransferase
Gene namesi
Name:Gk
Synonyms:Gyk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70893. Gk.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Glycerol kinasePRO_0000059539Add
BLAST

Proteomic databases

PaxDbiQ63060.
PRIDEiQ63060.

PTM databases

iPTMnetiQ63060.
PhosphoSiteiQ63060.

Interactioni

GO - Molecular functioni

  • histone binding Source: RGD

Protein-protein interaction databases

BioGridi249431. 1 interaction.
STRINGi10116.ENSRNOP00000059825.

Structurei

3D structure databases

ProteinModelPortaliQ63060.
SMRiQ63060. Positions 12-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
HOGENOMiHOG000222134.
HOVERGENiHBG002451.
InParanoidiQ63060.
KOiK00864.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE
60 70 80 90 100
GWVEQDPKEI LQSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW
110 120 130 140 150
DKLTGEPLYN AVVWLDLRTQ STVEKLSKRI PGNNNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWLLDN VKKVQEAVEE NRALFGTIDS WLIWSLTGGI NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKELC EFFGIPMEIL PNVRSSSEIY GLMKAGALEG
260 270 280 290 300
VPISGCLGDQ SAALVGQMCF QDGQAKNTYG TGCFLLCNTG HKCVFSEHGL
310 320 330 340 350
LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK SSEEIEKLAK
360 370 380 390 400
EVGTSYGCYF VPAFSALYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILDA MNRDCGIPLS HLQVDGGMTS NKILMQLQAD ILYIPVVKPS
460 470 480 490 500
MPETTALGAA MAAGAAEGVG VWSLEPEDLS AVTMERFEPQ INAEESEIRY
510 520
STWKKAVMKS IGWVTTQSPE SGIP
Length:524
Mass (Da):57,477
Last modified:November 1, 1996 - v1
Checksum:iA620C296D32B6B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16102 mRNA. Translation: BAA03677.1.
PIRiJN0606.
RefSeqiNP_077357.2. NM_024381.2.
UniGeneiRn.225941.

Genome annotation databases

GeneIDi79223.
KEGGirno:79223.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16102 mRNA. Translation: BAA03677.1.
PIRiJN0606.
RefSeqiNP_077357.2. NM_024381.2.
UniGeneiRn.225941.

3D structure databases

ProteinModelPortaliQ63060.
SMRiQ63060. Positions 12-516.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249431. 1 interaction.
STRINGi10116.ENSRNOP00000059825.

PTM databases

iPTMnetiQ63060.
PhosphoSiteiQ63060.

Proteomic databases

PaxDbiQ63060.
PRIDEiQ63060.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79223.
KEGGirno:79223.

Organism-specific databases

CTDi2710.
RGDi70893. Gk.

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
HOGENOMiHOG000222134.
HOVERGENiHBG002451.
InParanoidiQ63060.
KOiK00864.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Miscellaneous databases

PROiQ63060.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK_RAT
AccessioniPrimary (citable) accession number: Q63060
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.