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Protein

Glycerol kinase

Gene

Gk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP.By similarity1 Publication

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (Gk)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20SubstrateBy similarity1
Binding sitei24ATPBy similarity1
Binding sitei94SubstrateBy similarity1
Binding sitei148SubstrateBy similarity1
Binding sitei259SubstrateBy similarity1
Binding sitei281ATPBy similarity1
Binding sitei326ATP; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi427 – 431ATPBy similarity5

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • glycerol kinase activity Source: GO_Central
  • histone binding Source: RGD

GO - Biological processi

  • glycerol-3-phosphate biosynthetic process Source: GO_Central
  • glycerol catabolic process Source: UniProtKB-UniPathway
  • glycerol metabolic process Source: GO_Central
  • response to cold Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to organic substance Source: RGD
  • triglyceride metabolic process Source: GO_Central

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycerol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Short name:
GK
Short name:
Glycerokinase
Alternative name(s):
ATP-stimulated glucocorticoid-receptor translocation promoter
Short name:
ASTP
ATP:glycerol 3-phosphotransferase
Gene namesi
Name:Gk
Synonyms:Gyk
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70893 Gk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595391 – 524Glycerol kinaseAdd BLAST524

Proteomic databases

PaxDbiQ63060
PRIDEiQ63060

PTM databases

iPTMnetiQ63060
PhosphoSitePlusiQ63060

Interactioni

GO - Molecular functioni

  • histone binding Source: RGD

Protein-protein interaction databases

BioGridi249431, 1 interactor
STRINGi10116.ENSRNOP00000059825

Structurei

3D structure databases

ProteinModelPortaliQ63060
SMRiQ63060
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
HOGENOMiHOG000222134
HOVERGENiHBG002451
InParanoidiQ63060
KOiK00864

Family and domain databases

InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q63060-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE
60 70 80 90 100
GWVEQDPKEI LQSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW
110 120 130 140 150
DKLTGEPLYN AVVWLDLRTQ STVEKLSKRI PGNNNFVKSK TGLPLSTYFS
160 170 180 190 200
AVKLRWLLDN VKKVQEAVEE NRALFGTIDS WLIWSLTGGI NGGVHCTDVT
210 220 230 240 250
NASRTMLFNI HSLEWDKELC EFFGIPMEIL PNVRSSSEIY GLMKAGALEG
260 270 280 290 300
VPISGCLGDQ SAALVGQMCF QDGQAKNTYG TGCFLLCNTG HKCVFSEHGL
310 320 330 340 350
LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK SSEEIEKLAK
360 370 380 390 400
EVGTSYGCYF VPAFSALYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV
410 420 430 440 450
CFQTREILDA MNRDCGIPLS HLQVDGGMTS NKILMQLQAD ILYIPVVKPS
460 470 480 490 500
MPETTALGAA MAAGAAEGVG VWSLEPEDLS AVTMERFEPQ INAEESEIRY
510 520
STWKKAVMKS IGWVTTQSPE SGIP
Length:524
Mass (Da):57,477
Last modified:November 1, 1996 - v1
Checksum:iA620C296D32B6B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16102 mRNA Translation: BAA03677.1
PIRiJN0606
RefSeqiNP_077357.2, NM_024381.2
UniGeneiRn.225941

Genome annotation databases

GeneIDi79223
KEGGirno:79223

Similar proteinsi

Entry informationi

Entry nameiGLPK_RAT
AccessioniPrimary (citable) accession number: Q63060
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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