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Protein

ADP-ribosylation factor-related protein 1

Gene

Arfrp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318GTPBy similarity
Nucleotide bindingi75 – 795GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-related protein 1
Short name:
ARF-related protein 1
Short name:
ARP
Gene namesi
Name:Arfrp1
Synonyms:Arp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi621683. Arfrp1.

Subcellular locationi

  • Golgi apparatus
  • Golgi apparatustrans-Golgi network By similarity

  • Note: Located in the trans-Golgi in the GTP-bound active state.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201ADP-ribosylation factor-related protein 1PRO_0000207490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ63055.
PRIDEiQ63055.

PTM databases

PhosphoSiteiQ63055.

Expressioni

Tissue specificityi

Found in most tissues.

Gene expression databases

GenevisibleiQ63055. RN.

Interactioni

Subunit structurei

Interacts with SYS1.By similarity

Protein-protein interaction databases

MINTiMINT-4566431.
STRINGi10116.ENSRNOP00000019038.

Structurei

3D structure databases

ProteinModelPortaliQ63055.
SMRiQ63055. Positions 17-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0076. Eukaryota.
ENOG410ZMDV. LUCA.
GeneTreeiENSGT00550000074639.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ63055.
KOiK07952.
OMAiRDCLVQP.
OrthoDBiEOG76473Q.
PhylomeDBiQ63055.
TreeFamiTF105788.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL
60 70 80 90 100
SKITTTVGLN IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI
110 120 130 140 150
DSTDEERLSE SKEAFEKVVS SEALDGVPIL VLANKQDVET CLSIPDIKTA
160 170 180 190 200
FSDCTCKIGR RDCLTQACSA LTGKGVREGI EWMVKCVVRN VHRPPRQRDI

T
Length:201
Mass (Da):22,659
Last modified:November 1, 1996 - v1
Checksum:i7BB6D213946F597E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78603 mRNA. Translation: CAA55337.1.
RefSeqiNP_446432.1. NM_053980.1.
XP_006235780.1. XM_006235718.2.
UniGeneiRn.10973.

Genome annotation databases

EnsembliENSRNOT00000019038; ENSRNOP00000019038; ENSRNOG00000013992.
GeneIDi117051.
KEGGirno:117051.
UCSCiRGD:621683. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78603 mRNA. Translation: CAA55337.1.
RefSeqiNP_446432.1. NM_053980.1.
XP_006235780.1. XM_006235718.2.
UniGeneiRn.10973.

3D structure databases

ProteinModelPortaliQ63055.
SMRiQ63055. Positions 17-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4566431.
STRINGi10116.ENSRNOP00000019038.

PTM databases

PhosphoSiteiQ63055.

Proteomic databases

PaxDbiQ63055.
PRIDEiQ63055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019038; ENSRNOP00000019038; ENSRNOG00000013992.
GeneIDi117051.
KEGGirno:117051.
UCSCiRGD:621683. rat.

Organism-specific databases

CTDi10139.
RGDi621683. Arfrp1.

Phylogenomic databases

eggNOGiKOG0076. Eukaryota.
ENOG410ZMDV. LUCA.
GeneTreeiENSGT00550000074639.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ63055.
KOiK07952.
OMAiRDCLVQP.
OrthoDBiEOG76473Q.
PhylomeDBiQ63055.
TreeFamiTF105788.

Enzyme and pathway databases

ReactomeiR-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

PROiQ63055.

Gene expression databases

GenevisibleiQ63055. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors."
    Schuermann A., Massmann S., Joost H.-G.
    J. Biol. Chem. 270:30657-30663(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Heart muscle.

Entry informationi

Entry nameiARFRP_RAT
AccessioniPrimary (citable) accession number: Q63055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.