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Q63053

- ARC_RAT

UniProt

Q63053 - ARC_RAT

Protein

Activity-regulated cytoskeleton-associated protein

Gene

Arc

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration By similarity. Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.By similarity2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. cell migration Source: UniProtKB
    3. cytoskeleton organization Source: UniProtKB
    4. endocytosis Source: UniProtKB-KW
    5. endoderm development Source: Ensembl
    6. learning Source: RGD
    7. regulation of cell morphogenesis Source: UniProtKB
    8. regulation of neuronal synaptic plasticity Source: RGD

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activity-regulated cytoskeleton-associated protein
    Alternative name(s):
    ARC/ARG3.1
    Activity-regulated gene 3.1 protein
    Short name:
    Arg3.1
    Gene namesi
    Name:ArcImported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi62037. Arc.

    Subcellular locationi

    Cytoplasmcytoskeleton. Endosome 2 Publications. Cytoplasmic vesiclesecretory vesicleacrosome By similarity. Cytoplasmcell cortex. Cell projectiondendrite. Cell projectiondendritic spine. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density. Cell junctionsynapse
    Note: Enriched on the plasma membrane By similarity. Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.By similarity

    GO - Cellular componenti

    1. acrosomal vesicle Source: UniProtKB-SubCell
    2. actin cytoskeleton Source: RGD
    3. cell cortex Source: UniProtKB-SubCell
    4. cell junction Source: UniProtKB-KW
    5. cytoplasm Source: RGD
    6. dendritic spine Source: UniProtKB-SubCell
    7. endosome Source: UniProtKB-SubCell
    8. postsynaptic density Source: UniProtKB-SubCell
    9. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Membrane, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Activity-regulated cytoskeleton-associated proteinPRO_0000273287Add
    BLAST

    Proteomic databases

    PaxDbiQ63053.
    PRIDEiQ63053.

    PTM databases

    PhosphoSiteiQ63053.

    Expressioni

    Tissue specificityi

    Expressed exclusively in certain parts of the brain including cortex and molecular layer of the hippocampus. Typically expressed at high level in a minority of neurons. Basal expression higher in cortex than in hippocampus, highest in visual cortex.2 Publications

    Developmental stagei

    Expressed during postnatal development from day 8. Highest expression around day 23 with moderate levels expressed to adulthood.1 Publication

    Inductioni

    By synaptic activity in hippocampus, cerebral cortex, amygdala and hypothalamus. Highest level in hippocampus within 30 min, dropping to basal levels within 24 hours. By NGF and EGF in fibroblasts.2 Publications

    Gene expression databases

    GenevestigatoriQ63053.

    Interactioni

    Subunit structurei

    Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Camk2bP084136EBI-5275794,EBI-916155
    PSEN1P497683EBI-5275794,EBI-2606326From a different organism.

    Protein-protein interaction databases

    BioGridi248539. 2 interactions.
    IntActiQ63053. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ63053.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni89 – 10012Binds SH3GL1 or SH3GL31 PublicationAdd
    BLAST
    Regioni195 – 21420Required for binding DNM21 PublicationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili54 – 7825Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ARC/ARG3.1 family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG81608.
    GeneTreeiENSGT00390000003914.
    HOGENOMiHOG000034037.
    HOVERGENiHBG080862.
    KOiK15867.
    OMAiRCQETIA.
    OrthoDBiEOG75B855.
    PhylomeDBiQ63053.
    TreeFamiTF335604.

    Family and domain databases

    InterProiIPR023263. Activity-reg_cytoskelet-assoc.
    [Graphical view]
    PANTHERiPTHR15962. PTHR15962. 1 hit.
    PRINTSiPR02027. ARCARG31.

    Sequencei

    Sequence statusi: Complete.

    Q63053-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELDHMTTGG LHAYPAPRGG PAAKPNVILQ IGKCRAEMLE HVRRTHRHLL    50
    TEVSKQVERE LKGLHRSVGK LENNLDGYVP TGDSQRWKKS IKACLCRCQE 100
    TIANLERWVK REMHVWREVF YRLERWADRL ESMGGKYPVG SEPARHTVSV 150
    GVGGPEPYCQ EADGYDYTVS PYAITPPPAA GELPEQESVG AQQYQSWVPG 200
    EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS QIQNHMNGPA 250
    KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ 300
    FLWRKRDLYQ TLYVDAEEEE IIQYVVGTLQ PKFKRFLRHP LPKTLEQLIQ 350
    RGMEVQDGLE QAAEPSVTPL PTEDETEALT PALTSESVAS DRTQPE 396
    Length:396
    Mass (Da):45,353
    Last modified:November 1, 1996 - v1
    Checksum:i4E95B46B75853CA5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091V → L in AAA68695. (PubMed:7857651)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19866 mRNA. Translation: AAA68695.1.
    Z46925 mRNA. Translation: CAA87033.1.
    PIRiI58168.
    RefSeqiNP_062234.1. NM_019361.1.
    XP_006241796.1. XM_006241734.1.
    UniGeneiRn.10086.

    Genome annotation databases

    EnsembliENSRNOT00000067442; ENSRNOP00000063719; ENSRNOG00000043465.
    GeneIDi54323.
    KEGGirno:54323.
    UCSCiRGD:62037. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19866 mRNA. Translation: AAA68695.1 .
    Z46925 mRNA. Translation: CAA87033.1 .
    PIRi I58168.
    RefSeqi NP_062234.1. NM_019361.1.
    XP_006241796.1. XM_006241734.1.
    UniGenei Rn.10086.

    3D structure databases

    ProteinModelPortali Q63053.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248539. 2 interactions.
    IntActi Q63053. 6 interactions.

    PTM databases

    PhosphoSitei Q63053.

    Proteomic databases

    PaxDbi Q63053.
    PRIDEi Q63053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000067442 ; ENSRNOP00000063719 ; ENSRNOG00000043465 .
    GeneIDi 54323.
    KEGGi rno:54323.
    UCSCi RGD:62037. rat.

    Organism-specific databases

    CTDi 23237.
    RGDi 62037. Arc.

    Phylogenomic databases

    eggNOGi NOG81608.
    GeneTreei ENSGT00390000003914.
    HOGENOMi HOG000034037.
    HOVERGENi HBG080862.
    KOi K15867.
    OMAi RCQETIA.
    OrthoDBi EOG75B855.
    PhylomeDBi Q63053.
    TreeFami TF335604.

    Miscellaneous databases

    NextBioi 611018.
    PROi Q63053.

    Gene expression databases

    Genevestigatori Q63053.

    Family and domain databases

    InterProi IPR023263. Activity-reg_cytoskelet-assoc.
    [Graphical view ]
    PANTHERi PTHR15962. PTHR15962. 1 hit.
    PRINTSi PR02027. ARCARG31.
    ProtoNeti Search...

    Publicationsi

    1. "Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites."
      Lyford G.L., Yamagata K., Kaufmann W.E., Barnes C.A., Sanders L.K., Copeland N.G., Gilbert D.J., Jenkins N.A., Lanahan A.A., Worley P.F.
      Neuron 14:433-445(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
      Tissue: Hippocampus1 Publication.
    2. "Somatodendritic expression of an immediate early gene is regulated by synaptic activity."
      Link W., Konietzko U., Kauselmann G., Krug M., Schwanke B., Frey U., Kuhl D.
      Proc. Natl. Acad. Sci. U.S.A. 92:5734-5738(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
      Strain: Sprague-DawleyImported.
      Tissue: HippocampusImported.
    3. "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking."
      Chowdhury S., Shepherd J.D., Okuno H., Lyford G., Petralia R.S., Plath N., Kuhl D., Huganir R.L., Worley P.F.
      Neuron 52:445-459(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH DNM2; SH3GL1 AND SH3GL3.
    4. "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission."
      Rial Verde E.M., Lee-Osbourne J., Worley P.F., Malinow R., Cline H.T.
      Neuron 52:461-474(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA Receptors."
      Shepherd J.D., Rumbaugh G., Wu J., Chowdhury S., Plath N., Kuhl D., Huganir R.L., Worley P.F.
      Neuron 52:475-484(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiARC_RAT
    AccessioniPrimary (citable) accession number: Q63053
    Secondary accession number(s): Q62743
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Widely used as activity-dependent neuronal marker to identify recently activated neurons in behavioral studies.By similarity
    Neurons overexpressing Arc show reduced AMPA receptor-dependent synaptic transmission associated with reduced surface levels of AMPA receptor. This effect is dependent on NMDA receptor activity.2 Publications
    Transcripts enriched in dendrites may be translated locally.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3