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Protein

Liver carboxylesterase B-1

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei353Charge relay systemBy similarity1
Active sitei466Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERiratno-lmcxe Carb_B_Chordata
MEROPSiS09.969

Names & Taxonomyi

Protein namesi
Recommended name:
Liver carboxylesterase B-1 (EC:3.1.1.1)
Alternative name(s):
Liver microsomal carboxylesterase
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2366498

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000000858219 – 561Liver carboxylesterase B-1Add BLAST543

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 116By similarity
Disulfide bondi273 ↔ 284By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ63010
PRIDEiQ63010

PTM databases

iPTMnetiQ63010
PhosphoSitePlusiQ63010

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

ELMiQ63010
STRINGi10116.ENSRNOP00000024187

Structurei

3D structure databases

ProteinModelPortaliQ63010
SMRiQ63010
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi558 – 561Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
HOVERGENiHBG008839
PhylomeDBiQ63010

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q63010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLRSLFLVS LATCVVCGNP SSPPVVDTMK GKVLGKYASL EGVTQSVAVF
60 70 80 90 100
LGVPFAKPPL GSLRFAPPQP AEPWSFVKNT TTYPPMCSQD ATKGQRMNDL
110 120 130 140 150
LTNRKEKVHL QFSEDCLYLN IYTPADFTKD SRMPVMVWIH GGGLTQGGAS
160 170 180 190 200
TYDGQVLSAY ENVVVVAIQY RLGIWGFFST GDEHSRGNWG HLDQVAALHW
210 220 230 240 250
VQDNIANFGG DPGSVTIFGE SAGGFSVSVL VLSPLSKNLY HRAISESGVV
260 270 280 290 300
LITELFTKDV RPAAKQIADM AGCKTTTSAI IVHCLRQKTE EELLEIMEKM
310 320 330 340 350
NLIKLSSQRD TKESYHFLST VIDDVVLPKD PKEILAEKNF NTVPYIVGIN
360 370 380 390 400
KQECGWLLPT MMRFVPPDVK LDKKMAIMLL EKFASIYGIP EDIIPVAIEK
410 420 430 440 450
YRKGSDDPIK IRDGILAFIG DVLFCIPSVM VSRDHRDAGA PTYVYEYQYY
460 470 480 490 500
PSFSSPQRPK DVVGDHADDV YSVFGAPILR DGASEEEIKL SKMVMKFWAN
510 520 530 540 550
FARNGNPNAR GLPHWPQYDQ KEEYLQIGAT TQQSQRLKAE EVAFWTQLLA
560
KRQPQPHHNE L
Length:561
Mass (Da):62,495
Last modified:November 1, 1996 - v1
Checksum:i013C1C13ACEBC6C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19N → D AA sequence (PubMed:8597091).Curated1
Sequence conflicti29M → V AA sequence (PubMed:8597091).Curated1
Sequence conflicti38A → V AA sequence (PubMed:8597091).Curated1
Sequence conflicti422V → A in AAH79129 (PubMed:15489334).Curated1
Sequence conflicti509A → G in AAH79129 (PubMed:15489334).Curated1
Sequence conflicti536R → G in AAH79129 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10698 mRNA Translation: AAA64639.1
BC079129 mRNA Translation: AAH79129.1
PIRiS71597
RefSeqiNP_001019536.1, NM_001024365.1
UniGeneiRn.202952
Rn.82692

Genome annotation databases

GeneIDi501232
KEGGirno:501232

Similar proteinsi

Entry informationi

Entry nameiEST5_RAT
AccessioniPrimary (citable) accession number: Q63010
Secondary accession number(s): Q6AYA3, Q9QUX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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