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Protein

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates iodide uptake in the thyroid gland.

GO - Molecular functioni

  • sodium:iodide symporter activity Source: RGD

GO - Biological processi

  • anion transmembrane transport Source: GOC
  • iodide transport Source: RGD
  • sodium ion transmembrane transport Source: GOC
  • sodium ion transport Source: RGD
  • thyroid hormone generation Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/iodide cotransporter
Short name:
Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name:
Na(+)/I(-) symporter
Solute carrier family 5 member 5
Gene namesi
Name:Slc5a5
Synonyms:Nis
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69267. Slc5a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 5316CytoplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Topological domaini75 – 8814ExtracellularSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 13627CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Topological domaini158 – 1636ExtracellularSequence analysis
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 1862CytoplasmicSequence analysis
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Topological domaini208 – 24134ExtracellularSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST
Topological domaini263 – 28624CytoplasmicSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST
Topological domaini308 – 32619ExtracellularSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Topological domaini348 – 39144CytoplasmicSequence analysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence analysisAdd
BLAST
Topological domaini413 – 4164ExtracellularSequence analysis
Transmembranei417 – 43721HelicalSequence analysisAdd
BLAST
Topological domaini438 – 4447CytoplasmicSequence analysis
Transmembranei445 – 46521HelicalSequence analysisAdd
BLAST
Topological domaini466 – 52055ExtracellularSequence analysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence analysisAdd
BLAST
Topological domaini542 – 61877CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2331047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Sodium/iodide cotransporterPRO_0000105385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence analysis
Modified residuei551 – 5511Phosphoserine; by PKASequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63008.

PTM databases

PhosphoSiteiQ63008.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025577.

Chemistry

BindingDBiQ63008.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ63008.
KOiK14385.
PhylomeDBiQ63008.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAEAGARA TFGAWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG
60 70 80 90 100
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CAGQLLNSLL
110 120 130 140 150
TAFLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV
210 220 230 240 250
GFWVILARGV ILLGGPRNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFIVG
260 270 280 290 300
GTLVWLSMYG VNQAQVQRYV ACHTEGKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350
IVMFVYYKDC DPLLTGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRMPGLAP RKLVFISKGL SFIYGSACLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLA
460 470 480 490 500
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNDSVLL GPPGATNASN
510 520 530 540 550
GIPSSGMDTG RPALADTFYA ISYLYYGALG TLTTMLCGAL ISYLTGPTKR
560 570 580 590 600
SSLGPGLLWW DLARQTASVA PKEDTATLEE SLVKGPEDIP AVTKKPPGLK
610
PGAETHPLYL GHDVETNL
Length:618
Mass (Da):65,196
Last modified:November 1, 1996 - v1
Checksum:i91EFAA6752B4F4B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60282 mRNA. Translation: AAB03338.1.
PIRiS68513.
RefSeqiNP_443215.2. NM_052983.2.
UniGeneiRn.10505.

Genome annotation databases

GeneIDi114613.
KEGGirno:114613.
UCSCiRGD:69267. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60282 mRNA. Translation: AAB03338.1.
PIRiS68513.
RefSeqiNP_443215.2. NM_052983.2.
UniGeneiRn.10505.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025577.

Chemistry

BindingDBiQ63008.
ChEMBLiCHEMBL2331047.

PTM databases

PhosphoSiteiQ63008.

Proteomic databases

PaxDbiQ63008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114613.
KEGGirno:114613.
UCSCiRGD:69267. rat.

Organism-specific databases

CTDi6528.
RGDi69267. Slc5a5.

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ63008.
KOiK14385.
PhylomeDBiQ63008.

Miscellaneous databases

NextBioi618779.
PROiQ63008.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of the thyroid iodide transporter."
    Dai G., Levy O., Carrasco N.
    Nature 379:458-460(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thyroid.

Entry informationi

Entry nameiSC5A5_RAT
AccessioniPrimary (citable) accession number: Q63008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.