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Protein

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates iodide uptake in the thyroid gland.

GO - Molecular functioni

  • iodide transmembrane transporter activity Source: GO_Central
  • sodium:iodide symporter activity Source: RGD

GO - Biological processi

  • iodide transport Source: RGD
  • sodium ion transport Source: RGD
  • thyroid hormone generation Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/iodide cotransporter
Short name:
Na(+)/I(-) cotransporter
Alternative name(s):
Sodium-iodide symporter
Short name:
Na(+)/I(-) symporter
Solute carrier family 5 member 5
Gene namesi
Name:Slc5a5
Synonyms:Nis
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69267. Slc5a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 53CytoplasmicSequence analysisAdd BLAST16
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 88ExtracellularSequence analysisAdd BLAST14
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 136CytoplasmicSequence analysisAdd BLAST27
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 163ExtracellularSequence analysis6
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 186CytoplasmicSequence analysis2
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 241ExtracellularSequence analysisAdd BLAST34
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 286CytoplasmicSequence analysisAdd BLAST24
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 326ExtracellularSequence analysisAdd BLAST19
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 391CytoplasmicSequence analysisAdd BLAST44
Transmembranei392 – 412HelicalSequence analysisAdd BLAST21
Topological domaini413 – 416ExtracellularSequence analysis4
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Topological domaini438 – 444CytoplasmicSequence analysis7
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 520ExtracellularSequence analysisAdd BLAST55
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 618CytoplasmicSequence analysisAdd BLAST77

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2331047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053851 – 618Sodium/iodide cotransporterAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi485N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Modified residuei551Phosphoserine; by PKASequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ63008.
PRIDEiQ63008.

PTM databases

iPTMnetiQ63008.
PhosphoSitePlusiQ63008.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025577.

Chemistry databases

BindingDBiQ63008.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ63008.
KOiK14385.
PhylomeDBiQ63008.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q63008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAEAGARA TFGAWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG
60 70 80 90 100
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CAGQLLNSLL
110 120 130 140 150
TAFLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV
210 220 230 240 250
GFWVILARGV ILLGGPRNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFIVG
260 270 280 290 300
GTLVWLSMYG VNQAQVQRYV ACHTEGKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350
IVMFVYYKDC DPLLTGRISA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRMPGLAP RKLVFISKGL SFIYGSACLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLA
460 470 480 490 500
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNDSVLL GPPGATNASN
510 520 530 540 550
GIPSSGMDTG RPALADTFYA ISYLYYGALG TLTTMLCGAL ISYLTGPTKR
560 570 580 590 600
SSLGPGLLWW DLARQTASVA PKEDTATLEE SLVKGPEDIP AVTKKPPGLK
610
PGAETHPLYL GHDVETNL
Length:618
Mass (Da):65,196
Last modified:November 1, 1996 - v1
Checksum:i91EFAA6752B4F4B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60282 mRNA. Translation: AAB03338.1.
PIRiS68513.
RefSeqiNP_443215.2. NM_052983.2.
UniGeneiRn.10505.

Genome annotation databases

GeneIDi114613.
KEGGirno:114613.
UCSCiRGD:69267. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60282 mRNA. Translation: AAB03338.1.
PIRiS68513.
RefSeqiNP_443215.2. NM_052983.2.
UniGeneiRn.10505.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025577.

Chemistry databases

BindingDBiQ63008.
ChEMBLiCHEMBL2331047.

PTM databases

iPTMnetiQ63008.
PhosphoSitePlusiQ63008.

Proteomic databases

PaxDbiQ63008.
PRIDEiQ63008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114613.
KEGGirno:114613.
UCSCiRGD:69267. rat.

Organism-specific databases

CTDi6528.
RGDi69267. Slc5a5.

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ63008.
KOiK14385.
PhylomeDBiQ63008.

Miscellaneous databases

PROiQ63008.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A5_RAT
AccessioniPrimary (citable) accession number: Q63008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.