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Q62M77 (MURB_BURMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase
EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:BMA0374
OrganismBurkholderia mallei (Pseudomonas mallei) [Complete proteome] [HAMAP]
Taxonomic identifier13373 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length347 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 347347UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_0000224670

Regions

Domain24 – 195172FAD-binding PCMH-type

Sites

Active site1711 By similarity
Active site2471Proton donor By similarity
Active site3431 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62M77 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 12F5D8C8DE896006

FASTA34737,318
        10         20         30         40         50         60 
MSRPDSAVSL LPDYSLRAHN TFGFDARARV AARIGSPGQF ASLARDPRVA GLDRLVLGGG 

        70         80         90        100        110        120 
SNVVFTRDFD GLVLLDEIRG RALVREDDGA WYVEAGGGEN WHAFVEWTLA EGMPGLENLA 

       130        140        150        160        170        180 
LIPGTVGAAP IQNIGAYGLE MKEHFASLRA VDLATGELVE FDAARCAFGY RDSFFKRDGR 

       190        200        210        220        230        240 
GRFAIVAVTF RLPKAWTPRI GYADVARELA ARGIDARAAR ARDVFDAVVA IRRAKLPDPL 

       250        260        270        280        290        300 
ALGNAGSFFK NPVIDAQAFA ALRAREPDIV SYPQPDGRVK LAAGWLIDRC GWKGRALGAA 

       310        320        330        340 
AVHERQALVL VNLGGASGAD VLALAHAIRR DVLGRFGVEL EMEPVCL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000010 Genomic DNA. Translation: AAU49185.1.
RefSeqYP_102191.1. NC_006348.1.

3D structure databases

ProteinModelPortalQ62M77.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3090936.
GenomeReviewsGene locus BMA0374 in contig CP000010_GR.
KEGGbma:BMA0374.
PATRIC19115677. VBIBurMal55007_0377.
TIGRBMA0374.

Phylogenomic databases

HOGENOMHBG686573.
OMAIEQAGWK.
PhylomeDBQ62M77.
ProtClustDBPRK00046.

Enzyme and pathway databases

BioCycBMAL243160:BMA_0374-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_BURMA
AccessionPrimary (citable) accession number: Q62M77
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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