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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBMAL243160:G1G3W-1694-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BMA0510
OrganismiBurkholderia mallei (strain ATCC 23344)
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000006693 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058251 – 399Nicotinate phosphoribosyltransferaseAdd BLAST399

Interactioni

Protein-protein interaction databases

STRINGi243160.BMA0510

Structurei

3D structure databases

ProteinModelPortaliQ62LW1
SMRiQ62LW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q62LW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIITSLLDTD LYKFTMMQVV LHHFPAASVE YRFKCRTPGV DLVPYIDEIR
60 70 80 90 100
AEVRSLCELR FTDSELDYLR RLRFVKSDFV DFLALFHLNE KYISITPSQK
110 120 130 140 150
GGGEIDIEIK GPWLHTILFE IPVLAIVNEV YFRNTQRRPD YREGRGRLRE
160 170 180 190 200
KIKLLGAKPE FADCKIADYG TRRRFSKVWH EEVLRTLQDG LGPQFAGTSN
210 220 230 240 250
VYYAMTHEIT PLGTMAHEYL QACQALGPRL RDSQTYGLEM WAKEYRGDLG
260 270 280 290 300
IALSDVYGMD AFLRDFDMYF CKLFDGARHD SGDPFDWGER LIKHYEENRC
310 320 330 340 350
DPRTKVLVFS DALDIPKVMQ LYARFRGRCK LAFGVGTNLT NDLGYQPLQI
360 370 380 390
VIKMVRCNGQ PVAKLSDSPG KSMCDDKAYL AYLRQVFGIT QPPDDDAGK
Length:399
Mass (Da):45,962
Last modified:October 25, 2004 - v1
Checksum:i64300451032C4FA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000010 Genomic DNA Translation: AAU49773.1
RefSeqiWP_004192078.1, NC_006348.1
YP_102307.1, NC_006348.1

Genome annotation databases

EnsemblBacteriaiAAU49773; AAU49773; BMA0510
GeneIDi3089572
KEGGibma:BMA0510
PATRICifig|243160.12.peg.523

Similar proteinsi

Entry informationi

Entry nameiPNCB_BURMA
AccessioniPrimary (citable) accession number: Q62LW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 25, 2004
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health