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Q62LN5 (ASTD_BURMA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:BMA0594
OrganismBurkholderia mallei (Pseudomonas mallei) [Complete proteome] [HAMAP]
Taxonomic identifier13373 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_0000262388

Regions

Nucleotide binding221 – 2266NAD By similarity

Sites

Active site2441 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62LN5 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: DB4B0E0D06184BA2

FASTA48751,869
        10         20         30         40         50         60 
MTELFIDGAW RDGAGPVFAS RNPGTGEPVW EGAGASADDV ERAVASARRA FAAWSALDLD 

        70         80         90        100        110        120 
ARCAIVKRFA ALLVERKEAL ATMIGRETGK PLWEARTEVA SMAAKVDVSI AAYHERTGER 

       130        140        150        160        170        180 
RSPTADGVAV LRHRPHGVVA VFGPYNFPGH LPNGHIVPAL IAGNTVVFKP SELAPGVARA 

       190        200        210        220        230        240 
TVEIWRDAGL PAGVLNLVQG EKDTGVALAN HRQIDGLFFT GSSDTGTLLH RQFGGRPEIV 

       250        260        270        280        290        300 
LALEMGGNNP LVVADVEDID AAVHHAIQSA FLSAGQRCTC ARRILVPRGA FGDRFLERFA 

       310        320        330        340        350        360 
DVASRITADV YDADPQPFMG AVISARAASR LVAAQAKLLE LGAAPIIEMR QRDPALGFVN 

       370        380        390        400        410        420 
ASILDVTPVR ELPDEEHFGP LAQIVRYTDL DDAIARANDT AFGLSAGLLA DDETVWNTFR 

       430        440        450        460        470        480 
RTIRAGIVNW NRPTNGASSA APFGGAGRSG NHRPSAYYAA DYCAYPMASV ESAQLQMPAN 


LSPGLHF

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000010 Genomic DNA. Translation: AAU49290.1.
RefSeqYP_102384.1. NC_006348.1.

3D structure databases

ProteinModelPortalQ62LN5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3088507.
GenomeReviewsGene locus BMA0594 in contig CP000010_GR.
KEGGbma:BMA0594.
PATRIC19116157. VBIBurMal55007_0610.
TIGRBMA0594.

Phylogenomic databases

HOGENOMHBG752218.
OMAMTQRDPR.
PhylomeDBQ62LN5.
ProtClustDBPRK09457.

Enzyme and pathway databases

BioCycBMAL243160:BMA_0594-MONOMER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_BURMA
AccessionPrimary (citable) accession number: Q62LN5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 25, 2004
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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