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Q62LN3

- ASTE_BURMA

UniProt

Q62LN3 - ASTE_BURMA

Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotation

    Catalytic activityi

    N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi70 – 701ZincUniRule annotation
    Metal bindingi73 – 731ZincUniRule annotation
    Metal bindingi166 – 1661ZincUniRule annotation
    Active sitei229 – 2291UniRule annotation

    GO - Molecular functioni

    1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
    2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
    2. arginine catabolic process to succinate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00185; UER00283.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
    Gene namesi
    Name:astEUniRule annotation
    Ordered Locus Names:BMA0596
    OrganismiBurkholderia mallei (strain ATCC 23344)
    Taxonomic identifieri243160 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006693: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Succinylglutamate desuccinylasePRO_0000257705Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243160.BMA0596.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62LN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2988.
    HOGENOMiHOG000280300.
    KOiK05526.
    OMAiTAPIEIC.
    OrthoDBiEOG613070.

    Family and domain databases

    HAMAPiMF_00767. Arg_catab_AstE.
    InterProiIPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view]
    PfamiPF04952. AstE_AspA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017020. AstE. 1 hit.
    TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q62LN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSSADSGRD AAWLDDFLAL TLAGDAPPAE AGECAARAVR WRWLGDGLLR    50
    LEPADAAQRM QSVLVSAGVH GDETAPIELL STLVRDIARG ALPLRCRLLV 100
    ALGNPGAMRA GERYLDDDLN RLFGGRHAQL AASREAPRAA QLEAAAALFF 150
    STAGRARGAR WHIDMHTAIR TSVFEQFALL PHTGEPPTRT MFEWLGEAQI 200
    AAVLLHTTKG STFSHFTAQA CGALACTLEL GKVMPFGAND LSRFAPADAA 250
    VRRLVSGRRD APRGALPRAF TVVDQITKQS DALELFVAND VPNFTPFARG 300
    TLLARDGDYR YAVRHEQERI VFPNPSVKPG LRAGLLVIET TRDTHAALA 349
    Length:349
    Mass (Da):37,622
    Last modified:October 25, 2004 - v1
    Checksum:i1D1F32BB7F0A1AF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU49282.1.
    RefSeqiYP_102386.1. NC_006348.1.

    Genome annotation databases

    EnsemblBacteriaiAAU49282; AAU49282; BMA0596.
    GeneIDi3088388.
    KEGGibma:BMA0596.
    PATRICi19116161. VBIBurMal55007_0612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU49282.1 .
    RefSeqi YP_102386.1. NC_006348.1.

    3D structure databases

    ProteinModelPortali Q62LN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243160.BMA0596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU49282 ; AAU49282 ; BMA0596 .
    GeneIDi 3088388.
    KEGGi bma:BMA0596.
    PATRICi 19116161. VBIBurMal55007_0612.

    Phylogenomic databases

    eggNOGi COG2988.
    HOGENOMi HOG000280300.
    KOi K05526.
    OMAi TAPIEIC.
    OrthoDBi EOG613070.

    Enzyme and pathway databases

    UniPathwayi UPA00185 ; UER00283 .

    Family and domain databases

    HAMAPi MF_00767. Arg_catab_AstE.
    InterProi IPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view ]
    Pfami PF04952. AstE_AspA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017020. AstE. 1 hit.
    TIGRFAMsi TIGR03242. arg_catab_astE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23344.

    Entry informationi

    Entry nameiASTE_BURMA
    AccessioniPrimary (citable) accession number: Q62LN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3