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Q62L79

- Q62L79_BURMA

UniProt

Q62L79 - Q62L79_BURMA

Protein

ATP-dependent zinc metalloprotease FtsH

Gene

ftsH

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi416 – 4161Zinc; catalyticUniRule annotation
    Active sitei417 – 4171UniRule annotation
    Metal bindingi420 – 4201Zinc; catalyticUniRule annotation
    Metal bindingi492 – 4921Zinc; catalyticUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi194 – 2018ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP
    3. metalloendopeptidase activity Source: InterPro
    4. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. protein catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, MetalloproteaseUniRule annotation, Protease

    Keywords - Biological processi

    Cell cycle, Cell divisionImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

    Protein family/group databases

    MEROPSiM41.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent zinc metalloprotease FtsHUniRule annotation (EC:3.4.24.-UniRule annotation)
    Gene namesi
    Name:ftsHUniRule annotationImported
    Ordered Locus Names:BMA0777Imported
    OrganismiBurkholderia mallei (strain ATCC 23344)Imported
    Taxonomic identifieri243160 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006693: Chromosome 1

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membraneUniRule annotation, Cell membrane, Membrane

    Interactioni

    Subunit structurei

    Homohexamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243160.BMA0777.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62L79.
    SMRiQ62L79. Positions 143-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 10077PeriplasmicUniRule annotationAdd
    BLAST
    Topological domaini122 – 628507CytoplasmicUniRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321Helical;UniRule annotationAdd
    BLAST
    Transmembranei101 – 12121Helical;UniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation
    In the central section; belongs to the AAA ATPase family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000217276.
    KOiK03798.
    OMAiEAYTQAR.
    OrthoDBiEOG6PKFBJ.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_01458. FtsH.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR011546. Pept_M41_FtsH_extracell.
    IPR000642. Peptidase_M41.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF06480. FtsH_ext. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62L79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNNMFSKAA VWLVIALVLF TVFKQFDKPR VQEGVSYSQF MDDAKNGKVK    50
    NVVVQGRNLT VTPADGQKYQ IVSPGDIWMV GDLMKYGVQV SGKADDEPNA 100
    LVSALYYLGP TLLIIVFWFY MMRQMQGGGK GGAFSFGKSR ARLIDENNNA 150
    VNFSDVAGCD EAKEEVSELV DFLRDPQKFQ KLGGRIPRGV LLVGPPGTGK 200
    TLLARAIAGE AKVPFFSISG SDFVEMFVGV GAARVRDMFE QAKKHAPCIV 250
    FIDEIDAVGR HRGAGMGGGN DEREQTLNQM LVEMDGFEAN SGVIVIAATN 300
    RSDVLDKALL RPGRFDRQVY VGLPDIRGRE QIMRVHLRKV PIANDVDAAV 350
    IARGTPGFSG ADLANLVNEA ALFAARRGKR IVEMQDFEDA KDKIFMGPER 400
    KSAVIREEAK RATAYHESGH AVIAKLLPKA DPVHKVTIIP RGRALGVTWQ 450
    LPEHDNETYS KDYLLDRLAI LFGGRVAEEL FLNLVSTGAS DDFNKATQTA 500
    RAMVARFGMT DALGPMVYVD DENDGGPFGR GFTRTISEAT QQKVDAEIRR 550
    VLDEQYGLAR RLLEENRDKV EAMTAALMEW ETIDADQIND IMEGRPPRSP 600
    KSVPPAGDPS SGGSSGAEVK PGNATAPA 628
    Length:628
    Mass (Da):68,591
    Last modified:October 25, 2004 - v1
    Checksum:iE8296E68D2D6485A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU49561.1.
    RefSeqiYP_102540.1. NC_006348.1.

    Genome annotation databases

    EnsemblBacteriaiAAU49561; AAU49561; BMA0777.
    GeneIDi3089551.
    KEGGibma:BMA0777.
    PATRICi19116539. VBIBurMal55007_0800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU49561.1 .
    RefSeqi YP_102540.1. NC_006348.1.

    3D structure databases

    ProteinModelPortali Q62L79.
    SMRi Q62L79. Positions 143-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243160.BMA0777.

    Protein family/group databases

    MEROPSi M41.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU49561 ; AAU49561 ; BMA0777 .
    GeneIDi 3089551.
    KEGGi bma:BMA0777.
    PATRICi 19116539. VBIBurMal55007_0800.

    Phylogenomic databases

    HOGENOMi HOG000217276.
    KOi K03798.
    OMAi EAYTQAR.
    OrthoDBi EOG6PKFBJ.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_01458. FtsH.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR011546. Pept_M41_FtsH_extracell.
    IPR000642. Peptidase_M41.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF06480. FtsH_ext. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01241. FtsH_fam. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23344Imported.

    Entry informationi

    Entry nameiQ62L79_BURMA
    AccessioniPrimary (citable) accession number: Q62L79
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 25, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3