Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q62L79 (Q62L79_BURMA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent zinc metalloprotease FtsH HAMAP-Rule MF_01458

EC=3.4.24.- HAMAP-Rule MF_01458
Gene names
Name:ftsH HAMAP-Rule MF_01458 EMBL AAU49561.1
Ordered Locus Names:BMA0777 EMBL AAU49561.1
OrganismBurkholderia mallei (strain ATCC 23344) [Complete proteome] [HAMAP] EMBL AAU49561.1
Taxonomic identifier243160 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins By similarity. HAMAP-Rule MF_01458

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01458

Subunit structure

Homohexamer By similarity. HAMAP-Rule MF_01458

Subcellular location

Cell inner membrane; Multi-pass membrane protein; Cytoplasmic side By similarity HAMAP-Rule MF_01458.

Sequence similarities

In the C-terminal section; belongs to the peptidase M41 family. HAMAP-Rule MF_01458

In the central section; belongs to the AAA ATPase family. HAMAP-Rule MF_01458

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane3 – 2321Helical; By similarity HAMAP-Rule MF_01458
Topological domain24 – 10077Periplasmic By similarity HAMAP-Rule MF_01458
Transmembrane101 – 12121Helical; By similarity HAMAP-Rule MF_01458
Topological domain122 – 628507Cytoplasmic By similarity HAMAP-Rule MF_01458
Nucleotide binding194 – 2018ATP By similarity HAMAP-Rule MF_01458

Sites

Active site4171 By similarity HAMAP-Rule MF_01458
Metal binding4161Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4201Zinc; catalytic By similarity HAMAP-Rule MF_01458
Metal binding4921Zinc; catalytic By similarity HAMAP-Rule MF_01458

Sequences

Sequence LengthMass (Da)Tools
Q62L79 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: E8296E68D2D6485A

FASTA62868,591
        10         20         30         40         50         60 
MNNNMFSKAA VWLVIALVLF TVFKQFDKPR VQEGVSYSQF MDDAKNGKVK NVVVQGRNLT 

        70         80         90        100        110        120 
VTPADGQKYQ IVSPGDIWMV GDLMKYGVQV SGKADDEPNA LVSALYYLGP TLLIIVFWFY 

       130        140        150        160        170        180 
MMRQMQGGGK GGAFSFGKSR ARLIDENNNA VNFSDVAGCD EAKEEVSELV DFLRDPQKFQ 

       190        200        210        220        230        240 
KLGGRIPRGV LLVGPPGTGK TLLARAIAGE AKVPFFSISG SDFVEMFVGV GAARVRDMFE 

       250        260        270        280        290        300 
QAKKHAPCIV FIDEIDAVGR HRGAGMGGGN DEREQTLNQM LVEMDGFEAN SGVIVIAATN 

       310        320        330        340        350        360 
RSDVLDKALL RPGRFDRQVY VGLPDIRGRE QIMRVHLRKV PIANDVDAAV IARGTPGFSG 

       370        380        390        400        410        420 
ADLANLVNEA ALFAARRGKR IVEMQDFEDA KDKIFMGPER KSAVIREEAK RATAYHESGH 

       430        440        450        460        470        480 
AVIAKLLPKA DPVHKVTIIP RGRALGVTWQ LPEHDNETYS KDYLLDRLAI LFGGRVAEEL 

       490        500        510        520        530        540 
FLNLVSTGAS DDFNKATQTA RAMVARFGMT DALGPMVYVD DENDGGPFGR GFTRTISEAT 

       550        560        570        580        590        600 
QQKVDAEIRR VLDEQYGLAR RLLEENRDKV EAMTAALMEW ETIDADQIND IMEGRPPRSP 

       610        620 
KSVPPAGDPS SGGSSGAEVK PGNATAPA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000010 Genomic DNA. Translation: AAU49561.1.
RefSeqYP_102540.1. NC_006348.1.

3D structure databases

ProteinModelPortalQ62L79.
SMRQ62L79. Positions 143-397.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243160.BMA0777.

Protein family/group databases

MEROPSM41.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU49561; AAU49561; BMA0777.
GeneID3089551.
KEGGbma:BMA0777.
PATRIC19116539. VBIBurMal55007_0800.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000217276.
KOK03798.
OMAEQRNYSD.
OrthoDBEOG6PKFBJ.
ProtClustDBCLSK896995.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_01458. FtsH.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01241. FtsH_fam. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ62L79_BURMA
AccessionPrimary (citable) accession number: Q62L79
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)