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Protein

ATP-dependent zinc metalloprotease FtsH

Gene

ftsH

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi416 – 4161Zinc; catalyticUniRule annotation
Active sitei417 – 4171UniRule annotation
Metal bindingi420 – 4201Zinc; catalyticUniRule annotation
Metal bindingi492 – 4921Zinc; catalyticUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi194 – 2018ATPUniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. metalloendopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Biological processi

Cell cycle, Cell divisionImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FtsHUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ftsHUniRule annotationImported
Ordered Locus Names:BMA0777Imported
OrganismiBurkholderia mallei (strain ATCC 23344)Imported
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006693 Componenti: Chromosome 1

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Topological domaini24 – 10077PeriplasmicUniRule annotationAdd
BLAST
Transmembranei101 – 12121HelicalUniRule annotationAdd
BLAST
Topological domaini122 – 628507CytoplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi243160.BMA0777.

Structurei

3D structure databases

ProteinModelPortaliQ62L79.
SMRiQ62L79. Positions 143-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation
In the central section; belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOGENOMiHOG000217276.
KOiK03798.
OMAiAQVVEND.
OrthoDBiEOG6PKFBJ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62L79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNMFSKAA VWLVIALVLF TVFKQFDKPR VQEGVSYSQF MDDAKNGKVK
60 70 80 90 100
NVVVQGRNLT VTPADGQKYQ IVSPGDIWMV GDLMKYGVQV SGKADDEPNA
110 120 130 140 150
LVSALYYLGP TLLIIVFWFY MMRQMQGGGK GGAFSFGKSR ARLIDENNNA
160 170 180 190 200
VNFSDVAGCD EAKEEVSELV DFLRDPQKFQ KLGGRIPRGV LLVGPPGTGK
210 220 230 240 250
TLLARAIAGE AKVPFFSISG SDFVEMFVGV GAARVRDMFE QAKKHAPCIV
260 270 280 290 300
FIDEIDAVGR HRGAGMGGGN DEREQTLNQM LVEMDGFEAN SGVIVIAATN
310 320 330 340 350
RSDVLDKALL RPGRFDRQVY VGLPDIRGRE QIMRVHLRKV PIANDVDAAV
360 370 380 390 400
IARGTPGFSG ADLANLVNEA ALFAARRGKR IVEMQDFEDA KDKIFMGPER
410 420 430 440 450
KSAVIREEAK RATAYHESGH AVIAKLLPKA DPVHKVTIIP RGRALGVTWQ
460 470 480 490 500
LPEHDNETYS KDYLLDRLAI LFGGRVAEEL FLNLVSTGAS DDFNKATQTA
510 520 530 540 550
RAMVARFGMT DALGPMVYVD DENDGGPFGR GFTRTISEAT QQKVDAEIRR
560 570 580 590 600
VLDEQYGLAR RLLEENRDKV EAMTAALMEW ETIDADQIND IMEGRPPRSP
610 620
KSVPPAGDPS SGGSSGAEVK PGNATAPA
Length:628
Mass (Da):68,591
Last modified:October 25, 2004 - v1
Checksum:iE8296E68D2D6485A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000010 Genomic DNA. Translation: AAU49561.1.
RefSeqiYP_102540.1. NC_006348.1.

Genome annotation databases

EnsemblBacteriaiAAU49561; AAU49561; BMA0777.
GeneIDi3089551.
KEGGibma:BMA0777.
PATRICi19116539. VBIBurMal55007_0800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000010 Genomic DNA. Translation: AAU49561.1.
RefSeqiYP_102540.1. NC_006348.1.

3D structure databases

ProteinModelPortaliQ62L79.
SMRiQ62L79. Positions 143-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243160.BMA0777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU49561; AAU49561; BMA0777.
GeneIDi3089551.
KEGGibma:BMA0777.
PATRICi19116539. VBIBurMal55007_0800.

Phylogenomic databases

HOGENOMiHOG000217276.
KOiK03798.
OMAiAQVVEND.
OrthoDBiEOG6PKFBJ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23344Imported.

Entry informationi

Entry nameiQ62L79_BURMA
AccessioniPrimary (citable) accession number: Q62L79
Entry historyi
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: March 4, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.