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Q62JA4

- ALR_BURMA

UniProt

Q62JA4 - ALR_BURMA

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Protein
Alanine racemase
Gene
alr, BMA1575
Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanine By similarity
Binding sitei130 – 1301Substrate By similarity
Active sitei253 – 2531Proton acceptor; specific for L-alanine By similarity
Binding sitei301 – 3011Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase (EC:5.1.1.1)
Gene namesi
Name:alr
Ordered Locus Names:BMA1575
OrganismiBurkholderia mallei (strain ATCC 23344)
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006693: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Alanine racemaseUniRule annotation
PRO_1000065976Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi243160.BMA1575.

Structurei

3D structure databases

ProteinModelPortaliQ62JA4.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031446.
KOiK01775.
OMAiYGHGLER.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62JA4-1 [UniParc]FASTAAdd to Basket

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MPRPISATIH TAALANNLSV VRRHAAQSKV WAIVKANAYG HGLARVFPGL    50
RGTDGFGLLD LDEAVKLREL GWAGPILLLE GFFRSTDIDV IDRYSLTTAV 100
HNDEQMRMLE TARLSKPVNV QLKMNSGMNR LGYTPEKYRA AWERARACPG 150
IGQITLMTHF SDADGERGVA EQMATFERGA QGIAGARSFA NSAAVLWHPS 200
AHFDWVRPGI MLYGASPSGR AADIADRGLK PTMTLASELI AVQTLAKGQA 250
VGYGSMFVAE DTMRIGVVAC GYADGYPRIA PEGTPVVVDG VRTRIVGRVS 300
MDMLTVDLTP VPQAGVGARV ELWGETLPID DVAARCMTVG YELMCAVAPR 350
VPVRAE 356
Length:356
Mass (Da):38,334
Last modified:October 25, 2004 - v1
Checksum:iB29D6F1F142DD41E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000010 Genomic DNA. Translation: AAU47927.1.
RefSeqiYP_103215.1. NC_006348.1.

Genome annotation databases

EnsemblBacteriaiAAU47927; AAU47927; BMA1575.
GeneIDi3090876.
KEGGibma:BMA1575.
PATRICi19118210. VBIBurMal55007_1622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000010 Genomic DNA. Translation: AAU47927.1 .
RefSeqi YP_103215.1. NC_006348.1.

3D structure databases

ProteinModelPortali Q62JA4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243160.BMA1575.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU47927 ; AAU47927 ; BMA1575 .
GeneIDi 3090876.
KEGGi bma:BMA1575.
PATRICi 19118210. VBIBurMal55007_1622.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031446.
KOi K01775.
OMAi YGHGLER.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23344.

Entry informationi

Entry nameiALR_BURMA
AccessioniPrimary (citable) accession number: Q62JA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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