Reviewed, UniProtKB/Swiss-Prot Q62I89 (PYRB_BURMA)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BMA1994

Organism

Burkholderia mallei (Pseudomonas mallei) [Complete proteome] [HAMAP]

Taxonomic identifier

13373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Aspartate carbamoyltransferase		PRO_0000113112

Sequences

	Sequence		Length	Mass (Da)
	Q62I89-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: ADC079148CAAF53A	FASTA	343	37,387
	10 20 30 40 50 60 MTTDTSGRTG NPAAAAPAER FRYGFLKGNP QLTKNGELKH LLTIEGLPRA ILNQILDTAE 70 80 90 100 110 120 QFVSVTDREV KKVPLLRGKS VFNLFFENST RTRTTFEIAA KRLSADVINL NINASSTSKG 130 140 150 160 170 180 ESLLDTINNL SAMHADLFVV RHASSGAPYL IAEHCAPHVH VINAGDGRHA HPTQGLLDMY 190 200 210 220 230 240 TIRHYKRDFT KLRVAIVGDI LHSRVARSDI HALTTLGVPE VRAIGPRTLL PGGLEQMGVR 250 260 270 280 290 300 VFHNLDEGLR DVDVIIMLRL QNERMSGALL PSAQEYFKSW GLTPERLALA APDAIVMHPG 310 320 330 340 PMNRGVEIDS QVADGPQSVI LNQVTFGIAV RMAVMGIVAG TSD

References

[1]

"Structural flexibility in the Burkholderia mallei genome." Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E., Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M. , Kolonay J.F., Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004) [PubMed: 15377793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23344.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000010 Genomic DNA. Translation: AAU49994.1.
RefSeq	YP_103581.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3088399.
GenomeReviews	Gene locus BMA1994 in contig CP000010_GR.
KEGG	bma:BMA1994.
TIGR	BMA1994.
Phylogenomic databases
HOGENOM	Q62I89.
Enzyme and pathway databases
BioCyc	BMAL243160:BMA_1994-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BURMA

Accession

Primary (citable) accession number: Q62I89

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 25, 2004
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)