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Protein

D-(-)-3-hydroxybutyrate oligomer hydrolase

Gene

BMA2028

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D--3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.UniRule annotation

Catalytic activityi

(R)-3-((R)-3-hydroxybutanoyloxy)butanoate + H2O = 2 (R)-3-hydroxybutanoate.UniRule annotation

Pathwayi: butanoate metabolism

This protein is involved in the pathway butanoate metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway butanoate metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111Charge relay systemUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00863.

Names & Taxonomyi

Protein namesi
Recommended name:
D-(-)-3-hydroxybutyrate oligomer hydrolaseUniRule annotation (EC:3.1.1.22UniRule annotation)
Short name:
3HB-oligomer hydrolaseUniRule annotation
Short name:
3HBOHUniRule annotation
Gene namesi
Ordered Locus Names:BMA2028
OrganismiBurkholderia mallei (strain ATCC 23344)
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000006693 Componenti: Chromosome 1

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333UniRule annotationAdd
BLAST
Chaini34 – 699666D-(-)-3-hydroxybutyrate oligomer hydrolasePRO_0000314415Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243160.BMA2028.

Family & Domainsi

Sequence similaritiesi

Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106BE1. Bacteria.
ENOG410XSMB. LUCA.
HOGENOMiHOG000263490.
KOiK07518.
OMAiNPEKDWG.
OrthoDBiEOG6F293S.

Family and domain databases

Gene3Di3.40.50.1820. 3 hits.
HAMAPiMF_01906. 3HBOH.
InterProiIPR029058. AB_hydrolase.
IPR016582. OHBut_olig_hydro_put.
[Graphical view]
PfamiPF10605. 3HBOH. 1 hit.
[Graphical view]
PIRSFiPIRSF011409. HObutyrate_olig_hydrol. 1 hit.
SUPFAMiSSF53474. SSF53474. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62I60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIRGGSRR APGLALALLG GVLLGACHGD ENAQVNALPG FVSGSVRKTA
60 70 80 90 100
YDGASDDLLT AGLGKTGLGS DTRPGFANPA QPSAAELRRL AIYSNYRALV
110 120 130 140 150
DITPNGGYGR FWGPNVDLAG NDTLGEGKIA GTEYLAYSDD GSGRKNVTLL
160 170 180 190 200
VQVPASFDPA NPCIVTATAS GSRGVYGAIA AAGEWGLKRG CAVAYNDKGG
210 220 230 240 250
GNGAHEIGTG VVTLIDGTLA TASSAGSSSL FTASESSSTL AAFNSAFPNR
260 270 280 290 300
YAYKHAHSQQ NPEQDWGRVT LQAVEFAYWA LNEQFGPVVD GTRHGIRYRP
310 320 330 340 350
GDITTIAASV SNGGGSALAA AEQDTRGWIT AVVVGEPQIN VRMTPGVTVE
360 370 380 390 400
QGGAPVPSFG RPLADYATLA NLLQPCAAAA VAATGAPYLS ALPMGVTQSI
410 420 430 440 450
RTQRCATLAA AGLVSGADTA SQASDALAQL YAAGYLADSD LLQAPMWDSQ
460 470 480 490 500
AMPAIAVTYA NAYTRSRVTD NLCNFSFATT NPVTGAVAAP AVSPMTNLFG
510 520 530 540 550
AGNGVPPTNG INLVFNGASG GVDHRLATPD ASFAGAFCLR QLWTANQLGI
560 570 580 590 600
GTNVDAVRVA ANLQHKPAII VHGRSDALVP VNHASRAYVA QNSATEGRAS
610 620 630 640 650
QLSFYEVTNG QHFDAFLSVP GFDTRFVPVH YYDEQALNLM WNHLKSGAPL
660 670 680 690
PPSQVIRTVP RGGVPGAAPA LSTANLPPIV QSPGANAIAV NAGVIDVPL
Length:699
Mass (Da):71,704
Last modified:October 25, 2004 - v1
Checksum:i40EB2CFD4D033290
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000010 Genomic DNA. Translation: AAU49565.1.
RefSeqiWP_004186332.1. NC_006348.1.
YP_103610.1. NC_006348.1.

Genome annotation databases

EnsemblBacteriaiAAU49565; AAU49565; BMA2028.
GeneIDi3089438.
KEGGibma:BMA2028.
PATRICi19119165. VBIBurMal55007_2093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000010 Genomic DNA. Translation: AAU49565.1.
RefSeqiWP_004186332.1. NC_006348.1.
YP_103610.1. NC_006348.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243160.BMA2028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU49565; AAU49565; BMA2028.
GeneIDi3089438.
KEGGibma:BMA2028.
PATRICi19119165. VBIBurMal55007_2093.

Phylogenomic databases

eggNOGiENOG4106BE1. Bacteria.
ENOG410XSMB. LUCA.
HOGENOMiHOG000263490.
KOiK07518.
OMAiNPEKDWG.
OrthoDBiEOG6F293S.

Enzyme and pathway databases

UniPathwayiUPA00863.

Family and domain databases

Gene3Di3.40.50.1820. 3 hits.
HAMAPiMF_01906. 3HBOH.
InterProiIPR029058. AB_hydrolase.
IPR016582. OHBut_olig_hydro_put.
[Graphical view]
PfamiPF10605. 3HBOH. 1 hit.
[Graphical view]
PIRSFiPIRSF011409. HObutyrate_olig_hydrol. 1 hit.
SUPFAMiSSF53474. SSF53474. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23344.

Entry informationi

Entry nameiHBOH_BURMA
AccessioniPrimary (citable) accession number: Q62I60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 25, 2004
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.