Reviewed, UniProtKB/Swiss-Prot Q62I00 (KGUA_BURMA)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	BMA2096

Organism

Burkholderia mallei (Pseudomonas mallei) [Complete proteome] [HAMAP]

Taxonomic identifier

13373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Guanylate kinase HAMAP MF_00328		PRO_0000170513
Regions
	Domain	21 – 199	179	Guanylate kinase-like
	Nucleotide binding	28 – 35	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q62I00-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 3C5D8F8073257CA1	FASTA	227	25,459
	10 20 30 40 50 60 MTDSNRDGAA AHSLHAGVYP GNLFMVVAPS GAGKSTLVNA LLSKDPEIRL SISYTTRKPR 70 80 90 100 110 120 PGEQDGQHYH FTTVEDFRER HARHEFLESA EVHGNYYGTS RVWIEEQMKI GHDVLLEIDW 130 140 150 160 170 180 QGAQQVKKQF RNAVGIFILP PSLAALEERL KKRGQDEPNV ITRRLLAAGS EIAHAAEAQY 190 200 210 220 VVINETFEHA LAELECIVAA TRLRFTSQYA RHAELFVELG IHLPHAE

References

[1]

"Structural flexibility in the Burkholderia mallei genome." Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E., Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M. , Kolonay J.F., Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004) [PubMed: 15377793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23344.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000010 Genomic DNA. Translation: AAU50024.1.
RefSeq	YP_103670.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3088118.
GenomeReviews	Gene locus BMA2096 in contig CP000010_GR.
KEGG	bma:BMA2096.
TIGR	BMA2096.
Phylogenomic databases
HOGENOM	Q62I00.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	BMAL243160:BMA_2096-MON.
BRENDA	2.7.4.8. 260531.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_BURMA

Accession

Primary (citable) accession number: Q62I00

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 25, 2004
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)