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Q62HW8

- GLK_BURMA

UniProt

Q62HW8 - GLK_BURMA

Protein

Bifunctional protein glk

Gene

glk

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 286ATPSequence Analysis
    DNA bindingi377 – 39620H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbohydrate binding Source: InterPro
    3. DNA binding Source: UniProtKB-KW
    4. glucokinase activity Source: UniProtKB-EC
    5. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein glk
    Including the following 2 domains:
    Glucokinase (EC:2.7.1.2)
    Alternative name(s):
    Glucose kinase
    Putative HTH-type transcriptional regulator
    Gene namesi
    Name:glk
    Ordered Locus Names:BMA2132
    OrganismiBurkholderia mallei (strain ATCC 23344)
    Taxonomic identifieri243160 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006693: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 641641Bifunctional protein glkPRO_0000268797Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243160.BMA2132.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62HW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei576 – 59621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini341 – 41777HTH rpiR-typeAdd
    BLAST
    Domaini461 – 600140SISAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 340340GlucokinaseAdd
    BLAST
    Regioni341 – 641301Putative HTH-type transcriptional regulatorAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi591 – 63949Ala-richAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the bacterial glucokinase family.Curated
    Contains 1 SIS domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1737.
    HOGENOMiHOG000257466.
    KOiK00845.
    OMAiQYARKKW.
    OrthoDBiEOG64BQ47.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_00524. Glucokinase.
    InterProiIPR003836. Glucokinase.
    IPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF02685. Glucokinase. 1 hit.
    PF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    TIGRFAMsiTIGR00749. glk. 1 hit.
    PROSITEiPS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62HW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTGAQTKAA AASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA    50
    EYPTLTDAIR KYLKDAKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA 100
    TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQIGGGTRR QNSVIGLMGP 150
    GTGLGVSGLI PADDRWIALG SEGGHATFAP MDEREDLVLQ YARRKYPHVS 200
    FERVCAGPGM EIIYRALAAR DKKRIAANVD TADIVERAHA GDALALEAVE 250
    CFCAILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG 300
    RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM 350
    RDALTPAERR VADLALNHPR SIINDPIVNI ARKADVSQPT VIRFCRSLGC 400
    QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR 450
    EHLNFEHVEQ AIDILNNARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY 500
    GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS 550
    SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAA 600
    PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK D 641
    Length:641
    Mass (Da):68,376
    Last modified:October 25, 2004 - v1
    Checksum:i65D23DA89E0AD2EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU49971.1.
    RefSeqiYP_103702.1. NC_006348.1.

    Genome annotation databases

    EnsemblBacteriaiAAU49971; AAU49971; BMA2132.
    GeneIDi3091251.
    KEGGibma:BMA2132.
    PATRICi19119389. VBIBurMal55007_2200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU49971.1 .
    RefSeqi YP_103702.1. NC_006348.1.

    3D structure databases

    ProteinModelPortali Q62HW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243160.BMA2132.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU49971 ; AAU49971 ; BMA2132 .
    GeneIDi 3091251.
    KEGGi bma:BMA2132.
    PATRICi 19119389. VBIBurMal55007_2200.

    Phylogenomic databases

    eggNOGi COG1737.
    HOGENOMi HOG000257466.
    KOi K00845.
    OMAi QYARKKW.
    OrthoDBi EOG64BQ47.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_00524. Glucokinase.
    InterProi IPR003836. Glucokinase.
    IPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02685. Glucokinase. 1 hit.
    PF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    TIGRFAMsi TIGR00749. glk. 1 hit.
    PROSITEi PS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23344.

    Entry informationi

    Entry nameiGLK_BURMA
    AccessioniPrimary (citable) accession number: Q62HW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3