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Q62HW8

- GLK_BURMA

UniProt

Q62HW8 - GLK_BURMA

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Protein
Bifunctional protein glk
Gene
glk, BMA2132
Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 286ATP Reviewed prediction
DNA bindingi377 – 39620H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. carbohydrate binding Source: InterPro
  4. glucokinase activity Source: UniProtKB-EC
  5. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein glk
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Putative HTH-type transcriptional regulator
Gene namesi
Name:glk
Ordered Locus Names:BMA2132
OrganismiBurkholderia mallei (strain ATCC 23344)
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006693: Chromosome 1

Subcellular locationi

Membrane; Single-pass membrane protein Reviewed prediction UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei576 – 59621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 641641Bifunctional protein glkUniRule annotation
PRO_0000268797Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243160.BMA2132.

Structurei

3D structure databases

ProteinModelPortaliQ62HW8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 41777HTH rpiR-type
Add
BLAST
Domaini461 – 600140SIS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 340340GlucokinaseUniRule annotation
Add
BLAST
Regioni341 – 641301Putative HTH-type transcriptional regulatorUniRule annotation
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi591 – 63949Ala-richUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the bacterial glucokinase family.
Contains 1 SIS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1737.
HOGENOMiHOG000257466.
KOiK00845.
OMAiQYARKKW.
OrthoDBiEOG64BQ47.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62HW8-1 [UniParc]FASTAAdd to Basket

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MSTGAQTKAA AASQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA    50
EYPTLTDAIR KYLKDAKIGR VNHAAIAIAN PVDGDQVRMT NHNWSFSIEA 100
TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQIGGGTRR QNSVIGLMGP 150
GTGLGVSGLI PADDRWIALG SEGGHATFAP MDEREDLVLQ YARRKYPHVS 200
FERVCAGPGM EIIYRALAAR DKKRIAANVD TADIVERAHA GDALALEAVE 250
CFCAILGTFA GNLAVTLGAL GGIYIGGGVV PKLGELFMRS PFRARFEAKG 300
RFEAYLANIP TYLITAEYPA FLGVSAILAE QLSNRTGGAS SAVFERIRQM 350
RDALTPAERR VADLALNHPR SIINDPIVNI ARKADVSQPT VIRFCRSLGC 400
QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR 450
EHLNFEHVEQ AIDILNNARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY 500
GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS 550
SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLVMIDIL AVGVAIRRAA 600
PNAELAEAMA RAKARAGASA GDEAADVLDW LSHGAAPAAK D 641
Length:641
Mass (Da):68,376
Last modified:October 25, 2004 - v1
Checksum:i65D23DA89E0AD2EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000010 Genomic DNA. Translation: AAU49971.1.
RefSeqiYP_103702.1. NC_006348.1.

Genome annotation databases

EnsemblBacteriaiAAU49971; AAU49971; BMA2132.
GeneIDi3091251.
KEGGibma:BMA2132.
PATRICi19119389. VBIBurMal55007_2200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000010 Genomic DNA. Translation: AAU49971.1 .
RefSeqi YP_103702.1. NC_006348.1.

3D structure databases

ProteinModelPortali Q62HW8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243160.BMA2132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU49971 ; AAU49971 ; BMA2132 .
GeneIDi 3091251.
KEGGi bma:BMA2132.
PATRICi 19119389. VBIBurMal55007_2200.

Phylogenomic databases

eggNOGi COG1737.
HOGENOMi HOG000257466.
KOi K00845.
OMAi QYARKKW.
OrthoDBi EOG64BQ47.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_00524. Glucokinase.
InterProi IPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
TIGRFAMsi TIGR00749. glk. 1 hit.
PROSITEi PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23344.

Entry informationi

Entry nameiGLK_BURMA
AccessioniPrimary (citable) accession number: Q62HW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 25, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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