Reviewed, UniProtKB/Swiss-Prot Q62GE0 (HIS81_BURMA)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Synonyms:	hisC-1
Ordered Locus Names:	BMA2713

Organism

Burkholderia mallei (Pseudomonas mallei) [Complete proteome] [HAMAP]

Taxonomic identifier

13373 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153335
Amino acid modifications
	Modified residue	217	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q62GE0-1 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 6F985612DA171FE7	FASTA	356	38,142
	10 20 30 40 50 60 MTTPEDIIRR DVLAMTGYPV PDATGFVKLD AMENPYSLPA PLAAELGERL AHVALNRYPA 70 80 90 100 110 120 PRPAALIDRL RAVTGVPAAC DVLLGNGSDE IISMLAMACA KPGAKVLAPV PGFVMYELSA 130 140 150 160 170 180 KFAQLEFVGV PLRADLTLDI DAMLAALAEH RPALVYLAYP NNPTGTLYPD EDVERIIAAA 190 200 210 220 230 240 AASLVVIDEA YQPFAQRSWL PRAAQFDNVV VMRTMSKLGL AGIRLGYLVG LPAWLVQFDK 250 260 270 280 290 300 VRPPYNVNVL TQAAAEFLLE RVDVLDAQAA QLRDARTALA HAIGALPGAT VFPSAGNFLL 310 320 330 340 350 VRVPDAAAVF DVLLTERVLI KNVSKMHPLL ANCVRVTVGS PEENARLLAA LKLALP

References

[1]

"Structural flexibility in the Burkholderia mallei genome." Nierman W.C., DeShazer D., Kim H.S., Tettelin H., Nelson K.E., Feldblyum T.V., Ulrich R.L., Ronning C.M., Brinkac L.M., Daugherty S.C., Davidsen T.D., DeBoy R.T., Dimitrov G., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Khouri H.M. , Kolonay J.F., Madupu R., Mohammoud Y., Nelson W.C., Radune D., Romero C.M., Sarria S., Selengut J., Shamblin C., Sullivan S.A., White O., Yu Y., Zafar N., Zhou L., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 101:14246-14251(2004) [PubMed: 15377793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23344.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000010 Genomic DNA. Translation: AAU48281.1.
RefSeq	YP_104234.1.
3D structure databases
SMR	Q62GE0. Positions 4-353.
ModBase	Search...
Genome annotation databases
GeneID	3091283.
GenomeReviews	Gene locus BMA2713 in contig CP000010_GR.
KEGG	bma:BMA2713.
TIGR	BMA2713.
Phylogenomic databases
HOGENOM	HBG646350.
OMA	ANCLRVT.
PhylomeDB	Q62GE0.
Enzyme and pathway databases
BioCyc	BMAL243160:BMA_2713-MONOMER.
BRENDA	2.6.1.9. 260531.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_BURMA

Accession

Primary (citable) accession number: Q62GE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	October 25, 2004
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)