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Q62GD9

- HISX_BURMA

UniProt

Q62GD9 - HISX_BURMA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei138 – 1381NADUniRule annotation
    Binding sitei199 – 1991NADUniRule annotation
    Binding sitei222 – 2221NADUniRule annotation
    Binding sitei245 – 2451SubstrateUniRule annotation
    Metal bindingi267 – 2671ZincUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Metal bindingi270 – 2701ZincUniRule annotation
    Binding sitei270 – 2701SubstrateUniRule annotation
    Active sitei335 – 3351Proton acceptorUniRule annotation
    Active sitei336 – 3361Proton acceptorUniRule annotation
    Binding sitei336 – 3361SubstrateUniRule annotation
    Metal bindingi369 – 3691ZincUniRule annotation
    Binding sitei369 – 3691SubstrateUniRule annotation
    Binding sitei423 – 4231SubstrateUniRule annotation
    Metal bindingi428 – 4281ZincUniRule annotation
    Binding sitei428 – 4281SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:BMA2714
    OrganismiBurkholderia mallei (strain ATCC 23344)
    Taxonomic identifieri243160 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006693: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Histidinol dehydrogenasePRO_0000135748Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243160.BMA2714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62GD9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62GD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIKIRKLDS AGEGFAAELR AVLAFEASED DAIERAVAQI LADVKARGDA    50
    AVLDYTNRFD RLNAASVAAL ELPQSELEAA LEGLEPKRRA ALEAAAARVR 100
    GYHEKQKIEC GSHSWQYTEA DGTVLGQKVT PLDRVGLYVP GGKAAYPSSV 150
    LMNAIPARVA GVGEIVMVVP TPDGLKNDLV LAAALLGGVD RVFTIGGAQA 200
    VAALAYGTQT VPAVDKICGP GNAYVASAKR RVFGTVGIDM IAGPSEILVL 250
    CDGTTDPSWV AMDLFSQAEH DELAQSILLC PDEAFIERVE KAIGELLPTM 300
    PRQDVIRASL EGRGALVKVR DMAEACRIAN DIAPEHLEIS ALEPHQWGKQ 350
    IRHAGAIFLG RYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFFKRSS 400
    LIEVSAEGAH TLGEIASELA YGEGLQAHAK SAEYRMKGAG DRQKG 445
    Length:445
    Mass (Da):47,303
    Last modified:October 25, 2004 - v1
    Checksum:i7755036D7E02348C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU48282.1.
    RefSeqiYP_104235.1. NC_006348.1.

    Genome annotation databases

    EnsemblBacteriaiAAU48282; AAU48282; BMA2714.
    GeneIDi3091284.
    KEGGibma:BMA2714.
    PATRICi19120581. VBIBurMal55007_2784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU48282.1 .
    RefSeqi YP_104235.1. NC_006348.1.

    3D structure databases

    ProteinModelPortali Q62GD9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243160.BMA2714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU48282 ; AAU48282 ; BMA2714 .
    GeneIDi 3091284.
    KEGGi bma:BMA2714.
    PATRICi 19120581. VBIBurMal55007_2784.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23344.

    Entry informationi

    Entry nameiHISX_BURMA
    AccessioniPrimary (citable) accession number: Q62GD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3