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Q62GA0 (Q62GA0_BURMA) Unreviewed, UniProtKB/TrEMBL

Last modified May 16, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diaminopimelate decarboxylase HAMAP MF_02120
Short name=DAP decarboxylase HAMAP MF_02120
Short name=DAPDC HAMAP MF_02120
EC=4.1.1.20 HAMAP MF_02120
Gene names
Name:lysA HAMAP MF_02120
Ordered Locus Names:BMA2756
OrganismBurkholderia mallei (Pseudomonas mallei) [Complete proteome] [HAMAP]
Taxonomic identifier13373 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine By similarity. HAMAP MF_02120

Catalytic activity

Meso-2,6-diaminoheptanedioate = L-lysine + CO2. HAMAP MF_02120 RuleBase RU003738

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_02120 RuleBase RU003738 SAAS SAAS000183

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. HAMAP MF_02120 RuleBase RU003738

Subunit structure

Homodimer By similarity. HAMAP MF_02120

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily. HAMAP MF_02120

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region278 – 2814Pyridoxal phosphate binding By similarity HAMAP MF_02120

Sites

Binding site2411Pyridoxal phosphate; via amide nitrogen By similarity HAMAP MF_02120
Binding site2811Substrate By similarity HAMAP MF_02120
Binding site3171Substrate By similarity HAMAP MF_02120
Binding site3211Substrate By similarity HAMAP MF_02120
Binding site3491Substrate By similarity HAMAP MF_02120
Binding site3761Pyridoxal phosphate By similarity HAMAP MF_02120
Binding site3761Substrate By similarity HAMAP MF_02120

Amino acid modifications

Modified residue621N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_02120

Sequences

Sequence LengthMass (Da)Tools
Q62GA0 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: C8B498609408D298

FASTA42345,221
        10         20         30         40         50         60 
MTQAAFDYVD GTLHAERVST VELAERFGTP LFVYSRAALT AAYEAYAKAC AGRRASIHVA 

        70         80         90        100        110        120 
VKANSNLGVL NVFARLGAGF DIVSGGELAR VLAAGGRARD VVFSGVGKSA DEMRVALEAG 

       130        140        150        160        170        180 
VKCFNVESIP ELDRLNAVAA SLGKRAPVSL RVNPDVDPKT HPYISTGLKA NKFGIAFDDA 

       190        200        210        220        230        240 
RATYRAAAAL PNLEVVGIDC HIGSQITELS PYLDAIDKLL DLVERIEADG VQIHHVDVGG 

       250        260        270        280        290        300 
GLGITYDDET PPDIGAYVRA VLARIDARGH GQREIWFEPG RSLTGNAGIL LTRVEFLKQG 

       310        320        330        340        350        360 
EEKNFAIVDA AMNDLARPAM YQAFHAIVPV APRTDVAAAV YDIVGPVCES GDWLGRERSL 

       370        380        390        400        410        420 
AIAPGDLLAI RSAGAYGFTM SSNYNTRPRA AEVIVDGANA HLVRPRETVE SLFEHETILP 


EGR

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000010 Genomic DNA. Translation: AAU47904.1.
RefSeqYP_104274.1. NC_006348.1.

3D structure databases

ProteinModelPortalQ62GA0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3091324.
GenomeReviewsGene locus BMA2756 in contig CP000010_GR.
KEGGbma:BMA2756.
PATRIC19120663. VBIBurMal55007_2825.
TIGRBMA2756.

Phylogenomic databases

HOGENOMHOG000045070.
KOK01586.
OMADAHTHPY.
ProtClustDBCLSK897530.

Family and domain databases

Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
HAMAPMF_02120. LysA.
[Tree]
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR01048. LysA. 1 hit.
PROSITEPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ62GA0_BURMA
AccessionPrimary (citable) accession number: Q62GA0
Entry history
Integrated into UniProtKB/TrEMBL: October 25, 2004
Last sequence update: October 25, 2004
Last modified: May 16, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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