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Q62FN1

- GCSP_BURMA

UniProt

Q62FN1 - GCSP_BURMA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BMA2993
    OrganismiBurkholderia mallei (strain ATCC 23344)
    Taxonomic identifieri243160 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006693: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 975975Glycine dehydrogenase (decarboxylating)PRO_0000227097Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei723 – 7231N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi243160.BMA2993.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62FN1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q62FN1-1 [UniParc]FASTAAdd to Basket

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    MKLEHPDRLM NRTPLSLAAL ETHDAFAERH IGPDAASQQA MLDTLGFATR    50
    AALIDAVIPA SIRRAETLPL GPFAQPKSEA EALAALRALA DKNQVFRSYI 100
    GQGYYDTHTP AVILRNVLEN PAWYTAYTPY QPEISQGRLE ALLNFQQMVA 150
    DLTGLEISNA SLLDEATAAA EAMTLLQRVG KPQSNVFYVA DDVLPQTLEV 200
    IKTRAKPIGI EVKSGPAADA AAANAFGVLL QYPGANGDVR DYRALADAIH 250
    AAGGHVVVAA DILALTVLMP PGEWGADVAV GNTQRFGVPM GFGGPHAAYM 300
    AVRDEFKRQM PGRLVGVTVD AQGKPALRLA LQTREQHIRR EKATSNVCTA 350
    QALLAIMASM YAVYHGPRGL KTIALRVNRI AALLAAGIRH LGYATVNDTF 400
    FDTLTIDTGA RTAQLHAFAQ AKRINLRRAG DTRVGVSVDE TTTRADLADL 450
    LTIFAQAAGA TAPDIDALDA GLLPAPALPP SLERTSAYLT HHVFNRHHSE 500
    TEMLRYLRSL SDKDLALDRS MIPLGSCTMK LNATSEMLPV TWPEFGRIHP 550
    FAPAEQTVGY REMIDQLEQM LVAATGYAAV SLQPNAGSQG EYAGLLIIHA 600
    YHESRGESHR DVCLIPASAH GTNPASAHMA GMKVVVVACD AQGNVDIADL 650
    KAKADAHSHD LAAIMITYPS THGVFEQNVR EICEIVHAHG GQVYVDGANM 700
    NAMVGLTAPG QFGGDVSHLN LHKTFCIPHG GGGPGVGPVA VGPHLAKFLP 750
    NQRSTGYARG EDGIGAVSAA PYGSASILPI SWMYIAMMGA KNLTAATETA 800
    ILNANYIAKR LAPHYPVLYS GPGGLVAHEC ILDLRPIKDS SGITVDDVAK 850
    RLMDYGFHAP TMSFPVPGTL MVEPTESESQ EELDRFIAAM IAIRDEIRAV 900
    EEGRADREDN PLRHAPHTAA VVTANEWPHA YSREQAAFPV ASLVANKYWP 950
    PVGRADNAYG DRNLFCSCVP VSDYA 975
    Length:975
    Mass (Da):104,460
    Last modified:October 25, 2004 - v1
    Checksum:iF610AD40C9512103
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU48413.1.
    RefSeqiYP_104496.1. NC_006348.1.

    Genome annotation databases

    EnsemblBacteriaiAAU48413; AAU48413; BMA2993.
    GeneIDi3088654.
    KEGGibma:BMA2993.
    PATRICi19121155. VBIBurMal55007_3070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000010 Genomic DNA. Translation: AAU48413.1 .
    RefSeqi YP_104496.1. NC_006348.1.

    3D structure databases

    ProteinModelPortali Q62FN1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243160.BMA2993.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU48413 ; AAU48413 ; BMA2993 .
    GeneIDi 3088654.
    KEGGi bma:BMA2993.
    PATRICi 19121155. VBIBurMal55007_3070.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23344.

    Entry informationi

    Entry nameiGCSP_BURMA
    AccessioniPrimary (citable) accession number: Q62FN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3