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Q62FI7

- PCKG_BURMA

UniProt

Q62FI7 - PCKG_BURMA

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, BMA3042
Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881Substrate By similarity
Binding sitei229 – 2291Substrate; via amide nitrogen By similarity
Metal bindingi236 – 2361Manganese By similarity
Binding sitei236 – 2361Substrate By similarity
Metal bindingi256 – 2561Manganese; via tele nitrogen By similarity
Binding sitei278 – 2781Substrate By similarity
Active sitei280 – 2801 By similarity
Metal bindingi305 – 3051Manganese By similarity
Binding sitei401 – 4011GTP By similarity
Binding sitei432 – 4321GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi279 – 2846GTP By similarity
Nucleotide bindingi529 – 5324GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:BMA3042
OrganismiBurkholderia mallei (strain ATCC 23344)
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006693: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_0000103592Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243160.BMA3042.

Structurei

3D structure databases

ProteinModelPortaliQ62FI7.
SMRiQ62FI7. Positions 20-620.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni399 – 4013Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62FI7-1 [UniParc]FASTAAdd to Basket

« Hide

MTRSNVVAAT RTVPIDVPEY VKHRGLIDWV ARIAELTEPD RVVWCDGSQQ    50
EYDRLCDAMV EQRTMVRLNP AKRPNSFLAL SDPSDVARVE DRTFICSEHR 100
DDAGPTNHWV APAEMRATLN GLFRGAMRGR TLYVVPFSMG PLGSPIAHIG 150
VELSDSPYVV VNMRIMTRMG RAVLDALGER GEYVPCVHSV GRPLAAGEQD 200
VPWPCNPTKY IVHFPESREI WSFGSGYGGN ALLGKKCFAL RIASTMGRDE 250
GWLAEHMLIL GVTSPEGRKY HIAAAFPSAC GKTNFAMLIP PKGFEGWRVT 300
TIGDDIAWLK PGRDGRLYAI NPEAGYFGVA PGTGEKTNPN ALATLRENVI 350
FTNVALTEDG DVWWEGLTDT PPARLTDWQG NAWTPEIGRE TGRKAAHPNS 400
RFTAPASQCP SIDDDWENPG GVPIDAFIFG GRRSTTVPLV TEARDWIEGV 450
YMAATMGSET TAAAAGQQGI VRRDPFAMLP FCGYNMSDYF SHWLALGEKL 500
AAAGATLPKI YCVNWFRKDA DGRFAWPGFG ENMRVLKWML DRIDGRGEGV 550
EHAFGVTPRY EDLHWAGLAF SPAQYAQVTS MNPDEWRAEL ALHAELFDKL 600
SARLPDALAE TKARIEKRLG G 621
Length:621
Mass (Da):68,534
Last modified:October 25, 2004 - v1
Checksum:i685A6B4BF4291419
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000010 Genomic DNA. Translation: AAU48453.1.
RefSeqiYP_104540.1. NC_006348.1.

Genome annotation databases

EnsemblBacteriaiAAU48453; AAU48453; BMA3042.
GeneIDi3089419.
KEGGibma:BMA3042.
PATRICi19121253. VBIBurMal55007_3118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000010 Genomic DNA. Translation: AAU48453.1 .
RefSeqi YP_104540.1. NC_006348.1.

3D structure databases

ProteinModelPortali Q62FI7.
SMRi Q62FI7. Positions 20-620.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243160.BMA3042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU48453 ; AAU48453 ; BMA3042 .
GeneIDi 3089419.
KEGGi bma:BMA3042.
PATRICi 19121253. VBIBurMal55007_3118.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23344.

Entry informationi

Entry nameiPCKG_BURMA
AccessioniPrimary (citable) accession number: Q62FI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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