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Reviewed, UniProtKB/Swiss-Prot Q62EB0 (ATPA2_BURMA)

Last modified November 3, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ATP synthase subunit alpha 2
    EC=3.6.3.14
Alternative name(s):
    F-ATPase subunit alpha 2
    ATP synthase F1 sector subunit alpha 2
Gene names
Name: atpA2
Synonyms: atpA-2
Ordered Locus Names: BMAA0130
OrganismBurkholderia mallei (Pseudomonas mallei) [Complete proteome] [HAMAP]
Taxonomic identifier13373 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

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Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity.

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670ATP synthase subunit alpha 2 HAMAP MF_01346
PRO_0000238218

Regions

Nucleotide binding180 – 1878ATP By similarity

Sites

Site3731Required for activity By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q62EB0-1 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: 76A50643D8FB0FC8

FASTA67070,296
        10         20         30         40         50         60 
MTPTPDAPAA ADAATGAGWL ARRRGALARV ALAPIAQAIG RVERVADGIA FVSGLEDTML 

        70         80         90        100        110        120 
NEVLRFEGGV TGFAHTLDED LISVVLLDPD AGVRAQTAVA RTGAVLEVPA GPQLLGRVVD 

       130        140        150        160        170        180 
PLGRPLDGGA PLDAAHTLPI ERAAPAIIER DLVSEPLDTG VLIVDALFTI GRGQRELIIG 

       190        200        210        220        230        240 
DRATGKTSLA IDAIVNQRHS DVICVYVAIG QRASAVRRVI DAVRRYGAPE RCVFVVAPAA 

       250        260        270        280        290        300 
CAPGLQWIAP FAGFSIAEYF RDRGQHALVV VDDLTKHAAT HRELALLTRE PPGREAYPGD 

       310        320        330        340        350        360 
IFYVHARLLE RAAKLSAALG GGSLSALPIA ETDAGNLAAY IPTNLISITD GQIVLDSALF 

       370        380        390        400        410        420 
AANQRPAVDV GLSVSRVGGK AQHPALRAAS GRLRLDYAQF LELEAFTRFG GLTDARLRAQ 

       430        440        450        460        470        480 
ITRGERIRAL ITQPRFRALR TLDEVVLLKA LAAGTLDAMS PDLVAPLRER LPAWLDARIA 

       490        500        510        520        530        540 
ALTPALAPPR DWLADDAALD ALAESVGELI ERIAADAARR ATAGMPAEDA AGDIGGAFGG 

       550        560        570        580        590        600 
EQARGDADRD ADHGANREVS REVSPEASRE VSREVSREVS HEADRDAAAD AARVAGRAPG 

       610        620        630        640        650        660 
RAEPDRAVPR AMPDGPPRAQ ADGDRASASR PPPDARGDAA RTAPSPQGGA DANVNADANV 

       670 
DAEAEARHKR

« Hide

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Cross-references

Sequence databases

CP000011 Genomic DNA. Translation: AAU46326.1.
RefSeqYP_104968.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3087768.
GenomeReviewsGene locus BMAA0130 in contig CP000011_GR.
KEGGbma:BMAA0130.
TIGRBMAA0130.

Phylogenomic databases

HOGENOMQ62EB0.
OMANVLCVYC.

Enzyme and pathway databases

BioCycBMAL243160:BMA_A0130-MON.
BRENDA3.6.3.14. 260531.

Family and domain databases

HAMAPMF_01346.
[Tree]
InterProIPR005294. ATPase_F1-cplx_asu.
IPR017458. ATPase_F1-cplx_asu_C.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N.
IPR020003. ATPase_F1/V1/A1_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00962. atpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameATPA2_BURMA
AccessionPrimary (citable) accession number: Q62EB0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 25, 2004
Last modified: November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents