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Q62DU0

- GCH4_BURMA

UniProt

Q62DU0 - GCH4_BURMA

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (25 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei151 – 1511May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:BMAA0331
    OrganismiBurkholderia mallei (strain ATCC 23344)
    Taxonomic identifieri243160 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006693: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266GTP cyclohydrolase FolE2PRO_0000147706Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243160.BMAA0331.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62DU0.
    SMRiQ62DU0. Positions 18-262.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62DU0-1 [UniParc]FASTAAdd to Basket

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    MNPEFAMPDV QSTVDTRQMP IQRVGVRAVR HPLTVRTAEG ETQATVGTWN    50
    LDVHLPADQK GTHMSRFVAL LEERGGPLTA DAFRTMLATM LEKLEARAGR 100
    IEVSFPYFVN KTAPVSGVRS LLDYEVTLTG DVRDGLTRVF AKVLVPVTSL 150
    CPCSKKISQY GAHNQRSHVT IDAELAADVP VEDLIRIAEE EASCELWGLL 200
    KRPDEKFVTE RAYENPKFVE DLVRDVARRL DADERIVAYV LEAENFESIH 250
    NHSAYALIER DKRRGA 266
    Length:266
    Mass (Da):29,830
    Last modified:October 25, 2004 - v1
    Checksum:iE044BFDEC51BF31F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000011 Genomic DNA. Translation: AAU45982.1.
    RefSeqiYP_105138.1. NC_006349.2.

    Genome annotation databases

    EnsemblBacteriaiAAU45982; AAU45982; BMAA0331.
    GeneIDi3086315.
    KEGGibma:BMAA0331.
    PATRICi19122674. VBIBurMal55007_3826.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000011 Genomic DNA. Translation: AAU45982.1 .
    RefSeqi YP_105138.1. NC_006349.2.

    3D structure databases

    ProteinModelPortali Q62DU0.
    SMRi Q62DU0. Positions 18-262.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243160.BMAA0331.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU45982 ; AAU45982 ; BMAA0331 .
    GeneIDi 3086315.
    KEGGi bma:BMAA0331.
    PATRICi 19122674. VBIBurMal55007_3826.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23344.

    Entry informationi

    Entry nameiGCH4_BURMA
    AccessioniPrimary (citable) accession number: Q62DU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 25, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3