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Q62DU0 (GCH4_BURMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:BMAA0331
OrganismBurkholderia mallei (strain ATCC 23344) [Complete proteome] [HAMAP]
Taxonomic identifier243160 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147706

Sites

Site1511May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62DU0 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: E044BFDEC51BF31F

FASTA26629,830
        10         20         30         40         50         60 
MNPEFAMPDV QSTVDTRQMP IQRVGVRAVR HPLTVRTAEG ETQATVGTWN LDVHLPADQK 

        70         80         90        100        110        120 
GTHMSRFVAL LEERGGPLTA DAFRTMLATM LEKLEARAGR IEVSFPYFVN KTAPVSGVRS 

       130        140        150        160        170        180 
LLDYEVTLTG DVRDGLTRVF AKVLVPVTSL CPCSKKISQY GAHNQRSHVT IDAELAADVP 

       190        200        210        220        230        240 
VEDLIRIAEE EASCELWGLL KRPDEKFVTE RAYENPKFVE DLVRDVARRL DADERIVAYV 

       250        260 
LEAENFESIH NHSAYALIER DKRRGA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000011 Genomic DNA. Translation: AAU45982.1.
RefSeqYP_105138.1. NC_006349.2.

3D structure databases

ProteinModelPortalQ62DU0.
SMRQ62DU0. Positions 18-262.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243160.BMAA0331.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU45982; AAU45982; BMAA0331.
GeneID3086315.
KEGGbma:BMAA0331.
PATRIC19122674. VBIBurMal55007_3826.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BURMA
AccessionPrimary (citable) accession number: Q62DU0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways