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Q62DU0

- GCH4_BURMA

UniProt

Q62DU0 - GCH4_BURMA

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, BMAA0331
Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei151 – 1511May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:BMAA0331
OrganismiBurkholderia mallei (strain ATCC 23344)
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006693: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266GTP cyclohydrolase FolE2UniRule annotationPRO_0000147706Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243160.BMAA0331.

Structurei

3D structure databases

ProteinModelPortaliQ62DU0.
SMRiQ62DU0. Positions 18-262.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62DU0-1 [UniParc]FASTAAdd to Basket

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MNPEFAMPDV QSTVDTRQMP IQRVGVRAVR HPLTVRTAEG ETQATVGTWN    50
LDVHLPADQK GTHMSRFVAL LEERGGPLTA DAFRTMLATM LEKLEARAGR 100
IEVSFPYFVN KTAPVSGVRS LLDYEVTLTG DVRDGLTRVF AKVLVPVTSL 150
CPCSKKISQY GAHNQRSHVT IDAELAADVP VEDLIRIAEE EASCELWGLL 200
KRPDEKFVTE RAYENPKFVE DLVRDVARRL DADERIVAYV LEAENFESIH 250
NHSAYALIER DKRRGA 266
Length:266
Mass (Da):29,830
Last modified:October 25, 2004 - v1
Checksum:iE044BFDEC51BF31F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000011 Genomic DNA. Translation: AAU45982.1.
RefSeqiYP_105138.1. NC_006349.2.

Genome annotation databases

EnsemblBacteriaiAAU45982; AAU45982; BMAA0331.
GeneIDi3086315.
KEGGibma:BMAA0331.
PATRICi19122674. VBIBurMal55007_3826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000011 Genomic DNA. Translation: AAU45982.1 .
RefSeqi YP_105138.1. NC_006349.2.

3D structure databases

ProteinModelPortali Q62DU0.
SMRi Q62DU0. Positions 18-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243160.BMAA0331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU45982 ; AAU45982 ; BMAA0331 .
GeneIDi 3086315.
KEGGi bma:BMAA0331.
PATRICi 19122674. VBIBurMal55007_3826.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23344.

Entry informationi

Entry nameiGCH4_BURMA
AccessioniPrimary (citable) accession number: Q62DU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 25, 2004
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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