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Q62CK6 (UVRB_BURMA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UvrABC system protein B
Short name=Protein UvrB
Alternative name(s):
Excinuclease ABC subunit B
Gene names
Name:uvrB
Ordered Locus Names:BMAA0880
OrganismBurkholderia mallei (strain ATCC 23344) [Complete proteome] [HAMAP]
Taxonomic identifier243160 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›

Protein attributes

Sequence length696 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity. HAMAP-Rule MF_00204

Subunit structure

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00204.

Domain

The beta-hairpin motif is involved in DNA binding By similarity. HAMAP-Rule MF_00204

Sequence similarities

Belongs to the UvrB family.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 UVR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 696696UvrABC system protein B HAMAP-Rule MF_00204
PRO_0000227294

Regions

Domain46 – 433388Helicase ATP-binding
Domain450 – 616167Helicase C-terminal
Domain647 – 68236UVR
Nucleotide binding59 – 668ATP Potential
Motif112 – 13524Beta-hairpin HAMAP-Rule MF_00204

Sequences

Sequence LengthMass (Da)Tools
Q62CK6 [UniParc].

Last modified October 25, 2004. Version 1.
Checksum: F276C194D2005000

FASTA69679,428
        10         20         30         40         50         60 
MSEHHSDTRD DLDESKFVTF EGSPFQLYQP YPPSGDQPTA IATLVEGVED GLSFQTLLGV 

        70         80         90        100        110        120 
TGSGKTYTMA NTIARLGRPA IVFAPNKTLA AQLYAEFREF FPRNAVEYFV SYYDYYQPEA 

       130        140        150        160        170        180 
YVPQRDLFIE KDSSINEHIE QMRLSATKSL MERRDVVIVA TVSAIYGIGN PSEYHQMILT 

       190        200        210        220        230        240 
LRTGDKIGQR EVIARLIAMQ YTRNEQDFQR GTFRVRGDTI DIFPAEHAEM AVRVELFDDE 

       250        260        270        280        290        300 
VDTLHLFDPL TGRVRQKIPR FTVYPSSHYV TPRETVMRAV ETIKDELRER LEFFHRDGKL 

       310        320        330        340        350        360 
VEAQRLEQRT RFDLEMLQEL GFCKGIENYS RHFSGAAPGE PPPTLVDYLP PDALMLLDES 

       370        380        390        400        410        420 
HVLIGQLNGM YNGDRARKEN LVDYGFRLPS ALDNRPLKFP EFERKMRQVV FVSATPADYE 

       430        440        450        460        470        480 
QRVSGQTAEQ VVRPTGLVDP QIEVRPASTQ VDDVLSEITE RVKANERVLI TVLTKRMAEQ 

       490        500        510        520        530        540 
LTEFLADHGV KVRYLHSDID TVERVEIIRD LRLGTFDVLV GINLLREGLD IPEVSLVAIL 

       550        560        570        580        590        600 
DADKEGFLRA ERSLIQTIGR AARNVNGKAL LYADRITDSM RRAIDETERR RAKQIAYNEK 

       610        620        630        640        650        660 
MGITPRGVVK RIKDIIDGVY NADEARAELK EAQQRAKFED MSEKQIAKEI KRLEKQMADY 

       670        680        690 
AKNLEFEKAA QTRDQLALLR ERVFGANVGD HVSGGE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000011 Genomic DNA. Translation: AAU46751.1.
RefSeqYP_105572.1. NC_006349.2.

3D structure databases

ProteinModelPortalQ62CK6.
SMRQ62CK6. Positions 25-615.
ModBaseSearch...

Protein-protein interaction databases

STRING243160.BMAA0880.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU46751; AAU46751; BMAA0880.
GeneID3086196.
KEGGbma:BMAA0880.
PATRIC19123838. VBIBurMal55007_4401.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0556.
HOGENOMHOG000073580.
KOK03702.
OMACIYGLGI.
ProtClustDBPRK05298.

Family and domain databases

Gene3D4.10.860.10. 1 hit.
HAMAPMF_00204. UvrB.
InterProIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERPTHR24029. PTHR24029. 1 hit.
PfamPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF46600. UvrB_C. 1 hit.
TIGRFAMsTIGR00631. uvrb. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRB_BURMA
AccessionPrimary (citable) accession number: Q62CK6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 25, 2004
Last modified: May 29, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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