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Protein

1-aminocyclopropane-1-carboxylate deaminase

Gene

acdS

Organism
Burkholderia mallei (strain ATCC 23344)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source.UniRule annotation

Catalytic activityi

1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei78NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate deaminaseUniRule annotation (EC:3.5.99.7UniRule annotation)
Short name:
ACC deaminaseUniRule annotation
Short name:
ACCDUniRule annotation
Gene namesi
Name:acdSUniRule annotation
Ordered Locus Names:BMAA0952
OrganismiBurkholderia mallei (strain ATCC 23344)
Taxonomic identifieri243160 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000006693 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844981 – 3381-aminocyclopropane-1-carboxylate deaminaseAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi243160.BMAA0952.

Structurei

3D structure databases

ProteinModelPortaliQ62CE3.
SMRiQ62CE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ACC deaminase/D-cysteine desulfhydrase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K6H. Bacteria.
COG2515. LUCA.
HOGENOMiHOG000022460.
KOiK01505.
OMAiIGIRESW.

Family and domain databases

HAMAPiMF_00807. ACC_deaminase. 1 hit.
InterProiView protein in InterPro
IPR027278. ACCD_DCysDesulf.
IPR005965. ACP_carboxylate_deaminase.
IPR020601. ACP_carboxylate_deaminase_bac.
IPR001926. TrpB-like_PLP-dep.
PfamiView protein in Pfam
PF00291. PALP. 1 hit.
PIRSFiPIRSF006278. ACCD_DCysDesulf. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01274. ACC_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62CE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLQKFSRYP LTFGPTPIQP LKRLSAHLGG KVELYAKRDD CNSGLAFGGN
60 70 80 90 100
KTRKLEYLIP DALAQGCDTL VSIGGIQSNQ TRQVAAVAAH LGMKCVLVQE
110 120 130 140 150
NWVNYHDAVY DRVGNIQMSR MMGADVRLVP DGFDIGFRKS WEDALADVRA
160 170 180 190 200
RGGKPYAIPA GCSDHPLGGL GFVGFAEEVR AQEAELGFQF DYVVVCSVTG
210 220 230 240 250
STQAGMVVGF AADGRADRVI GVDASAKPAQ TREQILRIAK HTADRVELGR
260 270 280 290 300
DITSADVVLD ERFGGPEYGL PNEGTLEAIR LCAKLEGVLT DPVYEGKSMH
310 320 330
GMIEKVRLGE FPAGSKVLYA HLGGVPALNA YSFLFRDG
Length:338
Mass (Da):36,481
Last modified:October 25, 2004 - v1
Checksum:i64927D39E112B86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000011 Genomic DNA. Translation: AAU46138.1.
RefSeqiWP_004184549.1. NC_006349.2.
YP_105635.1. NC_006349.2.

Genome annotation databases

EnsemblBacteriaiAAU46138; AAU46138; BMAA0952.
GeneIDi3086675.
KEGGibma:BMAA0952.
PATRICifig|243160.12.peg.4473.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry namei1A1D_BURMA
AccessioniPrimary (citable) accession number: Q62CE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 25, 2004
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families