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Protein
Submitted name:

5HT3 receptor

Gene

Htr3a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
5HT3 receptorImported
Gene namesi
Name:Htr3aImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi61818. Htr3a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei242 – 26524HelicalSequence analysisAdd
BLAST
Transmembranei277 – 29822HelicalSequence analysisAdd
BLAST
Transmembranei304 – 32623HelicalSequence analysisAdd
BLAST
Transmembranei451 – 47424HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ62999.

Expressioni

Gene expression databases

GenevisibleiQ62999. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008965.

Structurei

3D structure databases

ProteinModelPortaliQ62999.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 241207Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini248 – 467220Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOVERGENiHBG106638.
KOiK04819.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERATLFLSV LIAQGEGSRR RATQAHSTTQ PALLRLSDHL LANYKKGVRP
60 70 80 90 100
VRDWRKPTLV SIDVIMYAIL NVDEKNQVLT TYIWYRQFWT DEFLQWTPED
110 120 130 140 150
FDNVTKLSIP TDSIWVPDIL INEFVDVGKS PSIPYVYVHH QGEVQNYKPL
160 170 180 190 200
QLVTACSLDI YNFPFDVQNC SLTFTSWLHT IQDINISLWR TPEEVRSDKS
210 220 230 240 250
IFINQGEWEL LGVFTKFQEF SIETSNSYAE MKFYVVIRRR PLFYAVSLLL
260 270 280 290 300
PSIFLMVVDI VGFCLPPDSG ERVSFKITLL LGYSVFLIIV SDTLPATAIG
310 320 330 340 350
TPLIGVYFVV CMALLVISLA ETIFIVQLVH KQDLQRPVPD WLRHLVLDRI
360 370 380 390 400
AWLLCLGEQP MAHRPPATFQ ANKTDDCSAM GNHCSHVGSP QDLEKTSRSR
410 420 430 440 450
DSPLPPPREA SLAVRGLLQE LSSIRHSLEK RDEMREVARD WLRVGYVLDR
460 470
LLFRIYLLAV LAYSITLVTL WSIWHYS
Length:477
Mass (Da):54,838
Last modified:November 1, 1996 - v1
Checksum:i3DCCFC34F175FCC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59672 mRNA. Translation: AAB02949.1.
RefSeqiNP_077370.2. NM_024394.2.
UniGeneiRn.55109.

Genome annotation databases

GeneIDi79246.
KEGGirno:79246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59672 mRNA. Translation: AAB02949.1.
RefSeqiNP_077370.2. NM_024394.2.
UniGeneiRn.55109.

3D structure databases

ProteinModelPortaliQ62999.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008965.

Proteomic databases

PaxDbiQ62999.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79246.
KEGGirno:79246.

Organism-specific databases

CTDi3359.
RGDi61818. Htr3a.

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
HOVERGENiHBG106638.
KOiK04819.

Gene expression databases

GenevisibleiQ62999. RN.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR008132. 5HT3_rcpt.
IPR008133. 5HT3_rcpt_A.
IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01709. 5HT3ARECEPTR.
PR01708. 5HT3RECEPTOR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat 5HT3 receptor sequence."
    Johnson D.S.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ62999_RAT
AccessioniPrimary (citable) accession number: Q62999
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.