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Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

Fut4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Pathwayi

GO - Molecular functioni

  1. alpha-(1->3)-fucosyltransferase activity Source: RGD

GO - Biological processi

  1. fucosylation Source: GOC
  2. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 4
Fucosyltransferase IV
Short name:
Fuc-TIV
Short name:
FucT-IV
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut4
Synonyms:Rfuc-t
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619954. Fut4.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein
Note: Membrane-bound form in trans cisternae of Golgi.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei55 – 7420Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini75 – 433359LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi cisterna membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Alpha-(1,3)-fucosyltransferase 4PRO_0000221103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62994.
PRIDEiQ62994.

Expressioni

Tissue specificityi

In adult, highest expression in spleen, testis, brain, lung, kidney and skeletal muscle and to a lesser extent in liver and heart.

Gene expression databases

GenevestigatoriQ62994.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012176.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283180.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ62994.
PhylomeDBiQ62994.

Family and domain databases

InterProiIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q62994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAGRKLQH ESRCRPSRPV DAWRAAATTR GRCMGTPGAR RTARRGGWGL
60 70 80 90 100
PRTSSGLAAA GLLCTALTAC LCWGQLPPLP WASPAPQRPV SVLLWWEPFG
110 120 130 140 150
GRGGHSKPPP DCSLRFNISG CRLLTDRAAY GEAQAVLFHH RDLVKGPPDW
160 170 180 190 200
PPPWGAQERT DEALELRVFD DQEGAVMLAR EALETTGSRP PGQRWVWMNF
210 220 230 240 250
ESPSHTPGLR GLAKDLFNWT LSYRTDSDIF VPYGFLYPRS HPAEQPSGLG
260 270 280 290 300
PPLARKRGLV AWVVSHWNER QARVRYYHQL RRHVSVDVFG RAGPGQPVPA
310 320 330 340 350
VGLLHTVARY KFYLAFENSQ HVDYNTEKLW RNAFLAGAVP VLLGPDRANY
360 370 380 390 400
EGFVPRGSFI HVDDFPSAAS LAAYLLFLDR NVAVYRRYFH WRRSYAVHIT
410 420 430
SFWDEPWCQT CRAVQTSGDQ PKSIHNLADW FQR
Length:433
Mass (Da):48,779
Last modified:October 31, 1996 - v1
Checksum:i75B0E569B72FD2F8
GO
Isoform Short (identifier: Q62994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:400
Mass (Da):45,104
Checksum:i32D009A92C432DC2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3333Missing in isoform Short. CuratedVSP_001779Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58860 Genomic DNA. Translation: AAB97609.1.
UniGeneiRn.44467.

Genome annotation databases

UCSCiRGD:619954. rat. [Q62994-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58860 Genomic DNA. Translation: AAB97609.1.
UniGeneiRn.44467.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012176.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Proteomic databases

PaxDbiQ62994.
PRIDEiQ62994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:619954. rat. [Q62994-1]

Organism-specific databases

RGDi619954. Fut4.

Phylogenomic databases

eggNOGiNOG283180.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ62994.
PhylomeDBiQ62994.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ62994.

Gene expression databases

GenevestigatoriQ62994.

Family and domain databases

InterProiIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a rat alpha1,3-fucosyltransferase gene: a member of the fucosyltransferase IV family."
    Sajdel-Sulkowska E.M., Smith F.I., Wiederschain G., McCluer R.H.
    Glycoconj. J. 14:249-258(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT).
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiFUT4_RAT
AccessioniPrimary (citable) accession number: Q62994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: October 31, 1996
Last modified: January 6, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.