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Q62994

- FUT4_RAT

UniProt

Q62994 - FUT4_RAT

Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

Fut4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

    Pathwayi

    GO - Molecular functioni

    1. alpha-(1->3)-fucosyltransferase activity Source: RGD

    GO - Biological processi

    1. fucosylation Source: GOC
    2. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
    Alternative name(s):
    Fucosyltransferase 4
    Fucosyltransferase IV
    Short name:
    Fuc-TIV
    Short name:
    FucT-IV
    Galactoside 3-L-fucosyltransferase
    Gene namesi
    Name:Fut4
    Synonyms:Rfuc-t
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619954. Fut4.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein
    Note: Membrane-bound form in trans cisternae of Golgi.

    GO - Cellular componenti

    1. Golgi cisterna membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Alpha-(1,3)-fucosyltransferase 4PRO_0000221103Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ62994.
    PRIDEiQ62994.

    Expressioni

    Tissue specificityi

    In adult, highest expression in spleen, testis, brain, lung, kidney and skeletal muscle and to a lesser extent in liver and heart.

    Gene expression databases

    GenevestigatoriQ62994.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012176.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini75 – 433359LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7420Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283180.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    InParanoidiQ62994.
    PhylomeDBiQ62994.

    Family and domain databases

    InterProiIPR001503. Glyco_trans_10.
    [Graphical view]
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiPF00852. Glyco_transf_10. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q62994-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPAGRKLQH ESRCRPSRPV DAWRAAATTR GRCMGTPGAR RTARRGGWGL    50
    PRTSSGLAAA GLLCTALTAC LCWGQLPPLP WASPAPQRPV SVLLWWEPFG 100
    GRGGHSKPPP DCSLRFNISG CRLLTDRAAY GEAQAVLFHH RDLVKGPPDW 150
    PPPWGAQERT DEALELRVFD DQEGAVMLAR EALETTGSRP PGQRWVWMNF 200
    ESPSHTPGLR GLAKDLFNWT LSYRTDSDIF VPYGFLYPRS HPAEQPSGLG 250
    PPLARKRGLV AWVVSHWNER QARVRYYHQL RRHVSVDVFG RAGPGQPVPA 300
    VGLLHTVARY KFYLAFENSQ HVDYNTEKLW RNAFLAGAVP VLLGPDRANY 350
    EGFVPRGSFI HVDDFPSAAS LAAYLLFLDR NVAVYRRYFH WRRSYAVHIT 400
    SFWDEPWCQT CRAVQTSGDQ PKSIHNLADW FQR 433
    Length:433
    Mass (Da):48,779
    Last modified:November 1, 1996 - v1
    Checksum:i75B0E569B72FD2F8
    GO
    Isoform Short (identifier: Q62994-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.

    Show »
    Length:400
    Mass (Da):45,104
    Checksum:i32D009A92C432DC2
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3333Missing in isoform Short. CuratedVSP_001779Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58860 Genomic DNA. Translation: AAB97609.1.
    UniGeneiRn.44467.

    Genome annotation databases

    UCSCiRGD:619954. rat. [Q62994-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58860 Genomic DNA. Translation: AAB97609.1 .
    UniGenei Rn.44467.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012176.

    Protein family/group databases

    CAZyi GT10. Glycosyltransferase Family 10.

    Proteomic databases

    PaxDbi Q62994.
    PRIDEi Q62994.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:619954. rat. [Q62994-1 ]

    Organism-specific databases

    RGDi 619954. Fut4.

    Phylogenomic databases

    eggNOGi NOG283180.
    HOGENOMi HOG000045583.
    HOVERGENi HBG000274.
    InParanoidi Q62994.
    PhylomeDBi Q62994.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    PROi Q62994.

    Gene expression databases

    Genevestigatori Q62994.

    Family and domain databases

    InterProi IPR001503. Glyco_trans_10.
    [Graphical view ]
    PANTHERi PTHR11929. PTHR11929. 1 hit.
    Pfami PF00852. Glyco_transf_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a rat alpha1,3-fucosyltransferase gene: a member of the fucosyltransferase IV family."
      Sajdel-Sulkowska E.M., Smith F.I., Wiederschain G., McCluer R.H.
      Glycoconj. J. 14:249-258(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT).
      Strain: Sprague-Dawley.
      Tissue: Kidney.

    Entry informationi

    Entry nameiFUT4_RAT
    AccessioniPrimary (citable) accession number: Q62994
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3