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Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

Fut4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 4
Fucosyltransferase IV
Short name:
Fuc-TIV
Short name:
FucT-IV
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut4
Synonyms:Rfuc-t
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619954. Fut4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
Transmembranei55 – 74Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini75 – 433LumenalSequence analysisAdd BLAST359

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211031 – 433Alpha-(1,3)-fucosyltransferase 4Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62994.
PRIDEiQ62994.

Expressioni

Tissue specificityi

In adult, highest expression in spleen, testis, brain, lung, kidney and skeletal muscle and to a lesser extent in liver and heart.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012176.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ62994.
PhylomeDBiQ62994.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 2 hits.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q62994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAGRKLQH ESRCRPSRPV DAWRAAATTR GRCMGTPGAR RTARRGGWGL
60 70 80 90 100
PRTSSGLAAA GLLCTALTAC LCWGQLPPLP WASPAPQRPV SVLLWWEPFG
110 120 130 140 150
GRGGHSKPPP DCSLRFNISG CRLLTDRAAY GEAQAVLFHH RDLVKGPPDW
160 170 180 190 200
PPPWGAQERT DEALELRVFD DQEGAVMLAR EALETTGSRP PGQRWVWMNF
210 220 230 240 250
ESPSHTPGLR GLAKDLFNWT LSYRTDSDIF VPYGFLYPRS HPAEQPSGLG
260 270 280 290 300
PPLARKRGLV AWVVSHWNER QARVRYYHQL RRHVSVDVFG RAGPGQPVPA
310 320 330 340 350
VGLLHTVARY KFYLAFENSQ HVDYNTEKLW RNAFLAGAVP VLLGPDRANY
360 370 380 390 400
EGFVPRGSFI HVDDFPSAAS LAAYLLFLDR NVAVYRRYFH WRRSYAVHIT
410 420 430
SFWDEPWCQT CRAVQTSGDQ PKSIHNLADW FQR
Length:433
Mass (Da):48,779
Last modified:November 1, 1996 - v1
Checksum:i75B0E569B72FD2F8
GO
Isoform Short (identifier: Q62994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:400
Mass (Da):45,104
Checksum:i32D009A92C432DC2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0017791 – 33Missing in isoform Short. CuratedAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58860 Genomic DNA. Translation: AAB97609.1.
UniGeneiRn.44467.

Genome annotation databases

UCSCiRGD:619954. rat. [Q62994-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58860 Genomic DNA. Translation: AAB97609.1.
UniGeneiRn.44467.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012176.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Proteomic databases

PaxDbiQ62994.
PRIDEiQ62994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:619954. rat. [Q62994-1]

Organism-specific databases

RGDi619954. Fut4.

Phylogenomic databases

eggNOGiKOG2619. Eukaryota.
ENOG410ZIMX. LUCA.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiQ62994.
PhylomeDBiQ62994.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ62994.

Family and domain databases

InterProiIPR031481. Glyco_tran_10_N.
IPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 2 hits.
PfamiPF17039. Glyco_tran_10_N. 1 hit.
PF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUT4_RAT
AccessioniPrimary (citable) accession number: Q62994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.