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Q62994 (FUT4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-(1,3)-fucosyltransferase 4

EC=2.4.1.-
Alternative name(s):
Fucosyltransferase 4
Fucosyltransferase IV
Short name=Fuc-TIV
Short name=FucT-IV
Galactoside 3-L-fucosyltransferase
Gene names
Name:Fut4
Synonyms:Rfuc-t
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein. Note: Membrane-bound form in trans cisternae of Golgi.

Tissue specificity

In adult, highest expression in spleen, testis, brain, lung, kidney and skeletal muscle and to a lesser extent in liver and heart.

Sequence similarities

Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
   Cellular componentGolgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfucosylation

Inferred from direct assay Ref.1. Source: GOC

protein glycosylation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentGolgi cisterna membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionalpha-(1->3)-fucosyltransferase activity

Inferred from direct assay Ref.1. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: Q62994-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: Q62994-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Alpha-(1,3)-fucosyltransferase 4
PRO_0000221103

Regions

Topological domain1 – 5454Cytoplasmic Potential
Transmembrane55 – 7420Helical; Signal-anchor for type II membrane protein; Potential
Topological domain75 – 433359Lumenal Potential

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation2181N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 3333Missing in isoform Short.
VSP_001779

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 75B0E569B72FD2F8

FASTA43348,779
        10         20         30         40         50         60 
MAPAGRKLQH ESRCRPSRPV DAWRAAATTR GRCMGTPGAR RTARRGGWGL PRTSSGLAAA 

        70         80         90        100        110        120 
GLLCTALTAC LCWGQLPPLP WASPAPQRPV SVLLWWEPFG GRGGHSKPPP DCSLRFNISG 

       130        140        150        160        170        180 
CRLLTDRAAY GEAQAVLFHH RDLVKGPPDW PPPWGAQERT DEALELRVFD DQEGAVMLAR 

       190        200        210        220        230        240 
EALETTGSRP PGQRWVWMNF ESPSHTPGLR GLAKDLFNWT LSYRTDSDIF VPYGFLYPRS 

       250        260        270        280        290        300 
HPAEQPSGLG PPLARKRGLV AWVVSHWNER QARVRYYHQL RRHVSVDVFG RAGPGQPVPA 

       310        320        330        340        350        360 
VGLLHTVARY KFYLAFENSQ HVDYNTEKLW RNAFLAGAVP VLLGPDRANY EGFVPRGSFI 

       370        380        390        400        410        420 
HVDDFPSAAS LAAYLLFLDR NVAVYRRYFH WRRSYAVHIT SFWDEPWCQT CRAVQTSGDQ 

       430 
PKSIHNLADW FQR 

« Hide

Isoform Short [UniParc].

Checksum: 32D009A92C432DC2
Show »

FASTA40045,104

References

[1]"Cloning of a rat alpha1,3-fucosyltransferase gene: a member of the fucosyltransferase IV family."
Sajdel-Sulkowska E.M., Smith F.I., Wiederschain G., McCluer R.H.
Glycoconj. J. 14:249-258(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT).
Strain: Sprague-Dawley.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U58860 Genomic DNA. Translation: AAB97609.1.
UniGeneRn.44467.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012176.

Protein family/group databases

CAZyGT10. Glycosyltransferase Family 10.

Proteomic databases

PaxDbQ62994.
PRIDEQ62994.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:619954. rat. [Q62994-1]

Organism-specific databases

RGD619954. Fut4.

Phylogenomic databases

eggNOGNOG283180.
HOGENOMHOG000045583.
HOVERGENHBG000274.
InParanoidQ62994.
PhylomeDBQ62994.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

GenevestigatorQ62994.

Family and domain databases

InterProIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERPTHR11929. PTHR11929. 1 hit.
PfamPF00852. Glyco_transf_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ62994.

Entry information

Entry nameFUT4_RAT
AccessionPrimary (citable) accession number: Q62994
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways