Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-(1,3)-fucosyltransferase 4

Gene

Fut4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-(1->3)-fucosyltransferase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 4
Fucosyltransferase IV
Short name:
Fuc-TIV
Short name:
FucT-IV
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut4
Synonyms:Rfuc-t
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619954 Fut4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
Transmembranei55 – 74Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini75 – 433LumenalSequence analysisAdd BLAST359

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211031 – 433Alpha-(1,3)-fucosyltransferase 4Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62994
PRIDEiQ62994

Expressioni

Tissue specificityi

In adult, highest expression in spleen, testis, brain, lung, kidney and skeletal muscle and to a lesser extent in liver and heart.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012176

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
HOGENOMiHOG000045583
HOVERGENiHBG000274
InParanoidiQ62994
PhylomeDBiQ62994

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q62994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAGRKLQH ESRCRPSRPV DAWRAAATTR GRCMGTPGAR RTARRGGWGL
60 70 80 90 100
PRTSSGLAAA GLLCTALTAC LCWGQLPPLP WASPAPQRPV SVLLWWEPFG
110 120 130 140 150
GRGGHSKPPP DCSLRFNISG CRLLTDRAAY GEAQAVLFHH RDLVKGPPDW
160 170 180 190 200
PPPWGAQERT DEALELRVFD DQEGAVMLAR EALETTGSRP PGQRWVWMNF
210 220 230 240 250
ESPSHTPGLR GLAKDLFNWT LSYRTDSDIF VPYGFLYPRS HPAEQPSGLG
260 270 280 290 300
PPLARKRGLV AWVVSHWNER QARVRYYHQL RRHVSVDVFG RAGPGQPVPA
310 320 330 340 350
VGLLHTVARY KFYLAFENSQ HVDYNTEKLW RNAFLAGAVP VLLGPDRANY
360 370 380 390 400
EGFVPRGSFI HVDDFPSAAS LAAYLLFLDR NVAVYRRYFH WRRSYAVHIT
410 420 430
SFWDEPWCQT CRAVQTSGDQ PKSIHNLADW FQR
Length:433
Mass (Da):48,779
Last modified:November 1, 1996 - v1
Checksum:i75B0E569B72FD2F8
GO
Isoform Short (identifier: Q62994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:400
Mass (Da):45,104
Checksum:i32D009A92C432DC2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0017791 – 33Missing in isoform Short. CuratedAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58860 Genomic DNA Translation: AAB97609.1
UniGeneiRn.44467

Genome annotation databases

UCSCiRGD:619954 rat [Q62994-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFUT4_RAT
AccessioniPrimary (citable) accession number: Q62994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health