Q62975Q5M8C2ZPI_RATProtein Z-dependent protease inhibitorPZ-dependent protease inhibitorPZIRegeneration-associated serpin 1RASP-1Serpin A10Serpina10Rasp1ZpiRattus norvegicusRatEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattuscDNA cloning of rasp-1, a novel gene encoding a plasma protein associated with liver regeneration.NUCLEOTIDE SEQUENCE [MRNA]TISSUE SPECIFICITYDEVELOPMENTAL STAGEThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).SecretedExpressed by the liver and secreted in plasma.In regenerating livers, it showed maximal expression 48 hours after hepatectomy, expression remaining elevated up to 2 weeks after liver removal.Phosphorylated by FAM20C in the extracellular medium.Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.Belongs to the serpin family.Blood coagulationGlycoproteinHemostasisHeparin-bindingProtease inhibitorReference proteomeSecretedSerine protease inhibitorSignalSTQRMRVVSSLFLPVLLAEVWLVSSFNLSSHSPEAPIRLVSQDYENQTWEEYEWADPRDDNEYWLRASQQLSNETSSFGFSLLRKISMRHDGNVIFSPFGLSVAMVNLMLGAKGETKVQVENGLNLQALSQAGPLILPALFKRVKETFSSNKKLGLTQGSFAFIHKDFEIKKTYFNLSTMYFDTEYVPTNFRNSSQARGLMNHYINKETEGKIPKLFDEINPETKLILVDYILFKGKWLTPFDPIFTEADTFHLDKYKAVKVPMMYREGNFASTFDKKFRCHILKLPYQGNATMLVVLMEKSGDHLALEDYLTTDLVEMWLQDMKTRKMEVFFPKFKLNQRYEMHELLKQVGIRRIFSTSADLSELSAVARNLQVSKVVQQSVLEVDERGTEVVSGTVSEITAYCMPPVIKVDRPFHFIIYEEMSQMLLFLGRVVNPTVL
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