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Protein

Protein Z-dependent protease inhibitor

Gene

Serpina10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei253 – 2531Essential for interaction with PROZBy similarity
Sitei306 – 3061Essential for interaction with PROZBy similarity
Sitei400 – 4012Reactive bondBy similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. negative regulation of endopeptidase activity Source: GO_Central
  3. regulation of proteolysis Source: GO_Central
  4. tissue regeneration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Z-dependent protease inhibitor
Short name:
PZ-dependent protease inhibitor
Short name:
PZI
Alternative name(s):
Regeneration-associated serpin 1
Short name:
RASP-1
Serpin A10
Gene namesi
Name:Serpina10
Synonyms:Rasp1, Zpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi621220. Serpina10.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 436416Protein Z-dependent protease inhibitorPRO_0000032485Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62975.
PRIDEiQ62975.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Developmental stagei

In regenerating livers, it showed maximal expression 48 hours after hepatectomy, expression remaining elevated up to 2 weeks after liver removal.1 Publication

Gene expression databases

GenevestigatoriQ62975.

Structurei

3D structure databases

ProteinModelPortaliQ62975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 14518Heparin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ62975.
OMAiQYFDMEF.
OrthoDBiEOG7DZ8JV.
PhylomeDBiQ62975.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62975-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVVSSLFLP VLLAEVWLVS SFNLSSHSPE APIRLVSQDY ENQTWEEYEW
60 70 80 90 100
ADPRDDNEYW LRASQQLSNE TSSFGFSLLR KISMRHDGNV IFSPFGLSVA
110 120 130 140 150
MVNLMLGAKG ETKVQVENGL NLQALSQAGP LILPALFKRV KETFSSNKKL
160 170 180 190 200
GLTQGSFAFI HKDFEIKKTY FNLSTMYFDT EYVPTNFRNS SQARGLMNHY
210 220 230 240 250
INKETEGKIP KLFDEINPET KLILVDYILF KGKWLTPFDP IFTEADTFHL
260 270 280 290 300
DKYKAVKVPM MYREGNFAST FDKKFRCHIL KLPYQGNATM LVVLMEKSGD
310 320 330 340 350
HLALEDYLTT DLVEMWLQDM KTRKMEVFFP KFKLNQRYEM HELLKQVGIR
360 370 380 390 400
RIFSTSADLS ELSAVARNLQ VSKVVQQSVL EVDERGTEVV SGTVSEITAY
410 420 430
CMPPVIKVDR PFHFIIYEEM SQMLLFLGRV VNPTVL
Length:436
Mass (Da):50,244
Last modified:July 5, 2005 - v2
Checksum:i4AAE8B3DB9F520CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281S → T in AAC52624. (PubMed:8670294)Curated
Sequence conflicti422 – 4221Q → R in AAC52624. (PubMed:8670294)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55765 mRNA. Translation: AAC52624.1.
BC088113 mRNA. Translation: AAH88113.1.
PIRiJC4841.
RefSeqiNP_598301.2. NM_133617.2.
XP_003750275.1. XM_003750227.3.
UniGeneiRn.10502.

Genome annotation databases

EnsembliENSRNOT00000073709; ENSRNOP00000064104; ENSRNOG00000050761.
ENSRNOT00000075378; ENSRNOP00000066602; ENSRNOG00000048988.
GeneIDi100909524.
171154.
KEGGirno:100909524.
rno:171154.
UCSCiRGD:621220. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55765 mRNA. Translation: AAC52624.1.
BC088113 mRNA. Translation: AAH88113.1.
PIRiJC4841.
RefSeqiNP_598301.2. NM_133617.2.
XP_003750275.1. XM_003750227.3.
UniGeneiRn.10502.

3D structure databases

ProteinModelPortaliQ62975.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.005.

Proteomic databases

PaxDbiQ62975.
PRIDEiQ62975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073709; ENSRNOP00000064104; ENSRNOG00000050761.
ENSRNOT00000075378; ENSRNOP00000066602; ENSRNOG00000048988.
GeneIDi100909524.
171154.
KEGGirno:100909524.
rno:171154.
UCSCiRGD:621220. rat.

Organism-specific databases

CTDi51156.
RGDi621220. Serpina10.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ62975.
OMAiQYFDMEF.
OrthoDBiEOG7DZ8JV.
PhylomeDBiQ62975.
TreeFamiTF343094.

Miscellaneous databases

NextBioi621988.
PROiQ62975.

Gene expression databases

GenevestigatoriQ62975.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of rasp-1, a novel gene encoding a plasma protein associated with liver regeneration."
    New L., Liu K., Kamali V., Plowman G., Naughton B.A., Purchio A.F.
    Biochem. Biophys. Res. Commun. 223:404-412(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Long Evans.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiZPI_RAT
AccessioniPrimary (citable) accession number: Q62975
Secondary accession number(s): Q5M8C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 5, 2005
Last modified: February 4, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.