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Q62975

- ZPI_RAT

UniProt

Q62975 - ZPI_RAT

Protein

Protein Z-dependent protease inhibitor

Gene

Serpina10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei253 – 2531Essential for interaction with PROZBy similarity
    Sitei306 – 3061Essential for interaction with PROZBy similarity
    Sitei400 – 4012Reactive bondBy similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of proteolysis Source: RefGenome
    4. tissue regeneration Source: RGD

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI04.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Z-dependent protease inhibitor
    Short name:
    PZ-dependent protease inhibitor
    Short name:
    PZI
    Alternative name(s):
    Regeneration-associated serpin 1
    Short name:
    RASP-1
    Serpin A10
    Gene namesi
    Name:Serpina10
    Synonyms:Rasp1, Zpi
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi621220. Serpina10.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 436416Protein Z-dependent protease inhibitorPRO_0000032485Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ62975.
    PRIDEiQ62975.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.1 Publication

    Developmental stagei

    In regenerating livers, it showed maximal expression 48 hours after hepatectomy, expression remaining elevated up to 2 weeks after liver removal.1 Publication

    Gene expression databases

    GenevestigatoriQ62975.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62975.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni128 – 14518Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00750000117448.
    HOGENOMiHOG000238519.
    HOVERGENiHBG101138.
    OMAiLLRKISM.
    OrthoDBiEOG7DZ8JV.
    PhylomeDBiQ62975.
    TreeFamiTF343094.

    Family and domain databases

    InterProiIPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62975-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVVSSLFLP VLLAEVWLVS SFNLSSHSPE APIRLVSQDY ENQTWEEYEW    50
    ADPRDDNEYW LRASQQLSNE TSSFGFSLLR KISMRHDGNV IFSPFGLSVA 100
    MVNLMLGAKG ETKVQVENGL NLQALSQAGP LILPALFKRV KETFSSNKKL 150
    GLTQGSFAFI HKDFEIKKTY FNLSTMYFDT EYVPTNFRNS SQARGLMNHY 200
    INKETEGKIP KLFDEINPET KLILVDYILF KGKWLTPFDP IFTEADTFHL 250
    DKYKAVKVPM MYREGNFAST FDKKFRCHIL KLPYQGNATM LVVLMEKSGD 300
    HLALEDYLTT DLVEMWLQDM KTRKMEVFFP KFKLNQRYEM HELLKQVGIR 350
    RIFSTSADLS ELSAVARNLQ VSKVVQQSVL EVDERGTEVV SGTVSEITAY 400
    CMPPVIKVDR PFHFIIYEEM SQMLLFLGRV VNPTVL 436
    Length:436
    Mass (Da):50,244
    Last modified:July 5, 2005 - v2
    Checksum:i4AAE8B3DB9F520CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281S → T in AAC52624. (PubMed:8670294)Curated
    Sequence conflicti422 – 4221Q → R in AAC52624. (PubMed:8670294)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55765 mRNA. Translation: AAC52624.1.
    BC088113 mRNA. Translation: AAH88113.1.
    PIRiJC4841.
    RefSeqiNP_598301.2. NM_133617.2.
    XP_003750275.1. XM_003750227.2.
    UniGeneiRn.10502.

    Genome annotation databases

    EnsembliENSRNOT00000073709; ENSRNOP00000064104; ENSRNOG00000050761.
    ENSRNOT00000075378; ENSRNOP00000066602; ENSRNOG00000048988.
    GeneIDi100909524.
    171154.
    KEGGirno:100909524.
    rno:171154.
    UCSCiRGD:621220. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55765 mRNA. Translation: AAC52624.1 .
    BC088113 mRNA. Translation: AAH88113.1 .
    PIRi JC4841.
    RefSeqi NP_598301.2. NM_133617.2.
    XP_003750275.1. XM_003750227.2.
    UniGenei Rn.10502.

    3D structure databases

    ProteinModelPortali Q62975.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.005.

    Proteomic databases

    PaxDbi Q62975.
    PRIDEi Q62975.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000073709 ; ENSRNOP00000064104 ; ENSRNOG00000050761 .
    ENSRNOT00000075378 ; ENSRNOP00000066602 ; ENSRNOG00000048988 .
    GeneIDi 100909524.
    171154.
    KEGGi rno:100909524.
    rno:171154.
    UCSCi RGD:621220. rat.

    Organism-specific databases

    CTDi 51156.
    RGDi 621220. Serpina10.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00750000117448.
    HOGENOMi HOG000238519.
    HOVERGENi HBG101138.
    OMAi LLRKISM.
    OrthoDBi EOG7DZ8JV.
    PhylomeDBi Q62975.
    TreeFami TF343094.

    Miscellaneous databases

    NextBioi 621988.
    PROi Q62975.

    Gene expression databases

    Genevestigatori Q62975.

    Family and domain databases

    InterProi IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of rasp-1, a novel gene encoding a plasma protein associated with liver regeneration."
      New L., Liu K., Kamali V., Plowman G., Naughton B.A., Purchio A.F.
      Biochem. Biophys. Res. Commun. 223:404-412(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: Long Evans.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiZPI_RAT
    AccessioniPrimary (citable) accession number: Q62975
    Secondary accession number(s): Q5M8C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3