Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein Z-dependent protease inhibitor

Gene

Serpina10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei253Essential for interaction with PROZBy similarity1
Sitei306Essential for interaction with PROZBy similarity1
Sitei400 – 401Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • tissue regeneration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI04.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Z-dependent protease inhibitor
Short name:
PZ-dependent protease inhibitor
Short name:
PZI
Alternative name(s):
Regeneration-associated serpin 1
Short name:
RASP-1
Serpin A10
Gene namesi
Name:Serpina10
Synonyms:Rasp1, Zpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621220. Serpina10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003248521 – 436Protein Z-dependent protease inhibitorAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62975.
PRIDEiQ62975.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Developmental stagei

In regenerating livers, it showed maximal expression 48 hours after hepatectomy, expression remaining elevated up to 2 weeks after liver removal.1 Publication

Gene expression databases

BgeeiENSRNOG00000048988.
GenevisibleiQ62975. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066602.

Structurei

3D structure databases

ProteinModelPortaliQ62975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 145Heparin-bindingBy similarityAdd BLAST18

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ62975.
KOiK04525.
OMAiKFRCHIL.
OrthoDBiEOG091G0ION.
PhylomeDBiQ62975.
TreeFamiTF343094.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVSSLFLP VLLAEVWLVS SFNLSSHSPE APIRLVSQDY ENQTWEEYEW
60 70 80 90 100
ADPRDDNEYW LRASQQLSNE TSSFGFSLLR KISMRHDGNV IFSPFGLSVA
110 120 130 140 150
MVNLMLGAKG ETKVQVENGL NLQALSQAGP LILPALFKRV KETFSSNKKL
160 170 180 190 200
GLTQGSFAFI HKDFEIKKTY FNLSTMYFDT EYVPTNFRNS SQARGLMNHY
210 220 230 240 250
INKETEGKIP KLFDEINPET KLILVDYILF KGKWLTPFDP IFTEADTFHL
260 270 280 290 300
DKYKAVKVPM MYREGNFAST FDKKFRCHIL KLPYQGNATM LVVLMEKSGD
310 320 330 340 350
HLALEDYLTT DLVEMWLQDM KTRKMEVFFP KFKLNQRYEM HELLKQVGIR
360 370 380 390 400
RIFSTSADLS ELSAVARNLQ VSKVVQQSVL EVDERGTEVV SGTVSEITAY
410 420 430
CMPPVIKVDR PFHFIIYEEM SQMLLFLGRV VNPTVL
Length:436
Mass (Da):50,244
Last modified:July 5, 2005 - v2
Checksum:i4AAE8B3DB9F520CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28S → T in AAC52624 (PubMed:8670294).Curated1
Sequence conflicti422Q → R in AAC52624 (PubMed:8670294).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55765 mRNA. Translation: AAC52624.1.
BC088113 mRNA. Translation: AAH88113.1.
PIRiJC4841.
RefSeqiNP_598301.2. NM_133617.2.
XP_003750275.1. XM_003750227.3.
UniGeneiRn.10502.

Genome annotation databases

EnsembliENSRNOT00000073709; ENSRNOP00000064104; ENSRNOG00000050761.
ENSRNOT00000075378; ENSRNOP00000066602; ENSRNOG00000048988.
GeneIDi100909524.
171154.
KEGGirno:100909524.
rno:171154.
UCSCiRGD:621220. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55765 mRNA. Translation: AAC52624.1.
BC088113 mRNA. Translation: AAH88113.1.
PIRiJC4841.
RefSeqiNP_598301.2. NM_133617.2.
XP_003750275.1. XM_003750227.3.
UniGeneiRn.10502.

3D structure databases

ProteinModelPortaliQ62975.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066602.

Protein family/group databases

MEROPSiI04.005.

Proteomic databases

PaxDbiQ62975.
PRIDEiQ62975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073709; ENSRNOP00000064104; ENSRNOG00000050761.
ENSRNOT00000075378; ENSRNOP00000066602; ENSRNOG00000048988.
GeneIDi100909524.
171154.
KEGGirno:100909524.
rno:171154.
UCSCiRGD:621220. rat.

Organism-specific databases

CTDi51156.
RGDi621220. Serpina10.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG101138.
InParanoidiQ62975.
KOiK04525.
OMAiKFRCHIL.
OrthoDBiEOG091G0ION.
PhylomeDBiQ62975.
TreeFamiTF343094.

Miscellaneous databases

PROiQ62975.

Gene expression databases

BgeeiENSRNOG00000048988.
GenevisibleiQ62975. RN.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZPI_RAT
AccessioniPrimary (citable) accession number: Q62975
Secondary accession number(s): Q5M8C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.