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Protein

Protein Z-dependent protease inhibitor

Gene

Serpina10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity).By similarity

Miscellaneous

Heparin acts as an important cofactor, producing 20 to 100-fold accelerations of SERPINA10 reactions with factor Xa and factor XIa.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei253Essential for interaction with PROZBy similarity1
Sitei306Essential for interaction with PROZBy similarity1
Sitei400 – 401Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • tissue regeneration Source: RGD

Keywordsi

Molecular functionHeparin-binding, Protease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI04.005

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Z-dependent protease inhibitor
Short name:
PZ-dependent protease inhibitor
Short name:
PZI
Alternative name(s):
Regeneration-associated serpin 1
Short name:
RASP-1
Serpin A10
Gene namesi
Name:Serpina10
Synonyms:Rasp1, Zpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621220 Serpina10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003248521 – 436Protein Z-dependent protease inhibitorAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62975
PRIDEiQ62975

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Developmental stagei

In regenerating livers, it showed maximal expression 48 hours after hepatectomy, expression remaining elevated up to 2 weeks after liver removal.1 Publication

Gene expression databases

BgeeiENSRNOG00000048988
GenevisibleiQ62975 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066602

Structurei

3D structure databases

ProteinModelPortaliQ62975
SMRiQ62975
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 145Heparin-bindingBy similarityAdd BLAST18

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118839
HOGENOMiHOG000238519
HOVERGENiHBG101138
InParanoidiQ62975
KOiK04525
OMAiAFIHKDF
OrthoDBiEOG091G0ION
PhylomeDBiQ62975
TreeFamiTF343094

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVVSSLFLP VLLAEVWLVS SFNLSSHSPE APIRLVSQDY ENQTWEEYEW
60 70 80 90 100
ADPRDDNEYW LRASQQLSNE TSSFGFSLLR KISMRHDGNV IFSPFGLSVA
110 120 130 140 150
MVNLMLGAKG ETKVQVENGL NLQALSQAGP LILPALFKRV KETFSSNKKL
160 170 180 190 200
GLTQGSFAFI HKDFEIKKTY FNLSTMYFDT EYVPTNFRNS SQARGLMNHY
210 220 230 240 250
INKETEGKIP KLFDEINPET KLILVDYILF KGKWLTPFDP IFTEADTFHL
260 270 280 290 300
DKYKAVKVPM MYREGNFAST FDKKFRCHIL KLPYQGNATM LVVLMEKSGD
310 320 330 340 350
HLALEDYLTT DLVEMWLQDM KTRKMEVFFP KFKLNQRYEM HELLKQVGIR
360 370 380 390 400
RIFSTSADLS ELSAVARNLQ VSKVVQQSVL EVDERGTEVV SGTVSEITAY
410 420 430
CMPPVIKVDR PFHFIIYEEM SQMLLFLGRV VNPTVL
Length:436
Mass (Da):50,244
Last modified:July 5, 2005 - v2
Checksum:i4AAE8B3DB9F520CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28S → T in AAC52624 (PubMed:8670294).Curated1
Sequence conflicti422Q → R in AAC52624 (PubMed:8670294).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55765 mRNA Translation: AAC52624.1
BC088113 mRNA Translation: AAH88113.1
PIRiJC4841
RefSeqiNP_598301.2, NM_133617.2
XP_003750275.1, XM_003750227.3
UniGeneiRn.10502

Genome annotation databases

EnsembliENSRNOT00000073709; ENSRNOP00000064104; ENSRNOG00000050761
ENSRNOT00000075378; ENSRNOP00000066602; ENSRNOG00000048988
GeneIDi100909524
171154
KEGGirno:100909524
rno:171154
UCSCiRGD:621220 rat

Similar proteinsi

Entry informationi

Entry nameiZPI_RAT
AccessioniPrimary (citable) accession number: Q62975
Secondary accession number(s): Q5M8C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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