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Protein

Sodium channel protein type 10 subunit alpha

Gene

Scn10a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.3 Publications

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: RGD

GO - Biological processi

  1. membrane depolarization during action potential Source: GO_Central
  2. neuronal action potential Source: GO_Central
  3. odontogenesis of dentin-containing tooth Source: RGD
  4. sensory perception of pain Source: RGD
  5. sodium ion transmembrane transport Source: GOC
  6. sodium ion transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi1.A.1.10.6. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 10 subunit alpha
Alternative name(s):
Peripheral nerve sodium channel 3
Short name:
PN3
Sensory neuron sodium channel
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
Gene namesi
Name:Scn10a
Synonyms:Sns
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3629. Scn10a.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity
Note: It can be translocated to the extracellular membrane through association with S100A10.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei126 – 14924Helical; Name=S1 of repeat ISequence AnalysisAdd
BLAST
Transmembranei155 – 17420Helical; Name=S2 of repeat ISequence AnalysisAdd
BLAST
Transmembranei188 – 20619Helical; Name=S3 of repeat ISequence AnalysisAdd
BLAST
Transmembranei213 – 23220Helical; Voltage-sensor; Name=S4 of repeat ISequence AnalysisAdd
BLAST
Transmembranei249 – 27224Helical; Name=S5 of repeat ISequence AnalysisAdd
BLAST
Transmembranei373 – 39826Helical; Name=S6 of repeat ISequence AnalysisAdd
BLAST
Transmembranei659 – 68325Helical; Name=S1 of repeat IISequence AnalysisAdd
BLAST
Transmembranei695 – 71824Helical; Name=S2 of repeat IISequence AnalysisAdd
BLAST
Transmembranei727 – 74620Helical; Name=S3 of repeat IISequence AnalysisAdd
BLAST
Transmembranei753 – 77220Helical; Voltage-sensor; Name=S4 of repeat IISequence AnalysisAdd
BLAST
Transmembranei789 – 80921Helical; Name=S5 of repeat IISequence AnalysisAdd
BLAST
Transmembranei864 – 88926Helical; Name=S6 of repeat IISequence AnalysisAdd
BLAST
Transmembranei1149 – 117224Helical; Name=S1 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1186 – 121126Helical; Name=S2 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1218 – 123922Helical; Name=S3 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1244 – 126522Helical; Voltage-sensor; Name=S4 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1285 – 131228Helical; Name=S5 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1393 – 141927Helical; Name=S6 of repeat IIISequence AnalysisAdd
BLAST
Transmembranei1473 – 149624Helical; Name=S1 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1508 – 153124Helical; Name=S2 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1538 – 156124Helical; Name=S3 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1574 – 159522Helical; Voltage-sensor; Name=S4 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1611 – 163323Helical; Name=S5 of repeat IVSequence AnalysisAdd
BLAST
Transmembranei1699 – 172325Helical; Name=S6 of repeat IVSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. clathrin complex Source: RGD
  2. integral component of membrane Source: RGD
  3. plasma membrane Source: GO_Central
  4. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19561956Sodium channel protein type 10 subunit alphaPRO_0000048509Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1323 – 13231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1329 – 13291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1337 – 13371N-linked (GlcNAc...)Sequence Analysis
Modified residuei1452 – 14521Phosphoserine; by PKCBy similarity
Glycosylationi1687 – 16871N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Ubiquitinated by NEDD4L; which promotes its endocytosis.By similarity
Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62968.
PRIDEiQ62968.

PTM databases

PhosphoSiteiQ62968.

Expressioni

Tissue specificityi

Expressed in dorsal root ganglia, trigeminal ganglia, nodose ganglia and sciatic nerve.3 Publications

Developmental stagei

Expressed in dorsal root ganglia at 15 dpc onwards.1 Publication

Inductioni

Down-regulated after axotomy in dorsal root ganglia.1 Publication

Gene expression databases

GenevestigatoriQ62968.

Interactioni

Subunit structurei

The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Dynlt1Q9Z3362EBI-1800320,EBI-920359
PrxQ634252EBI-1800320,EBI-1800492
S100a10P059434EBI-1800320,EBI-1800351

Protein-protein interaction databases

IntActiQ62968. 23 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ62968.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 399275IAdd
BLAST
Repeati658 – 890233IIAdd
BLAST
Repeati1148 – 1420273IIIAdd
BLAST
Repeati1472 – 1724253IVAdd
BLAST
Domaini1852 – 188130IQAdd
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 IQ domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ62968.
KOiK04842.
PhylomeDBiQ62968.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028809. Na_channel_a10su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF23. PTHR10037:SF23. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q62968-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPFASVGT TNFRRFTPES LAEIEKQIAA HRAAKKARTK HRGQEDKGEK
60 70 80 90 100
PRPQLDLKAC NQLPKFYGEL PAELVGEPLE DLDPFYSTHR TFMVLNKSRT
110 120 130 140 150
ISRFSATWAL WLFSPFNLIR RTAIKVSVHS WFSIFITITI LVNCVCMTRT
160 170 180 190 200
DLPEKVEYVF TVIYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA
210 220 230 240 250
YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVRKLADVT
260 270 280 290 300
ILTVFCLSVF ALVGLQLFKG NLKNKCIRNG TDPHKADNLS SEMAEYIFIK
310 320 330 340 350
PGTTDPLLCG NGSDAGHCPG GYVCLKTPDN PDFNYTSFDS FAWAFLSLFR
360 370 380 390 400
LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE
410 420 430 440 450
EQSQATIAEI EAKEKKFQEA LEVLQKEQEV LAALGIDTTS LQSHSGSPLA
460 470 480 490 500
SKNANERRPR VKSRVSEGST DDNRSPQSDP YNQRRMSFLG LSSGRRRASH
510 520 530 540 550
GSVFHFRAPS QDISFPDGIT DDGVFHGDQE SRRGSILLGR GAGQTGPLPR
560 570 580 590 600
SPLPQSPNPG RRHGEEGQLG VPTGELTAGA PEGPALDTTG QKSFLSAGYL
610 620 630 640 650
NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISFAQK YLIWECCPKW
660 670 680 690 700
RKFKMALFEL VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN
710 720 730 740 750
IVFTVFFTME MAFKIIAFDP YYYFQKKWNI FDCVIVTVSL LELSASKKGS
760 770 780 790 800
LSVLRTFRLL RVFKLAKSWP TLNTLIKIIG NSVGALGNLT FILAIIVFIF
810 820 830 840 850
ALVGKQLLSE DYGCRKDGVS VWNGEKLRWH MCDFFHSFLV VFRILCGEWI
860 870 880 890 900
ENMWVCMEVS QKSICLILFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP
910 920 930 940 950
EDDGEVNNLQ LALARIQVLG HRASRAIASY ISSHCRFRWP KVETQLGMKP
960 970 980 990 1000
PLTSSEAKNH IATDAVSAAV GNLTKPALSS PKENHGDFIT DPNVWVSVPI
1010 1020 1030 1040 1050
AEGESDLDEL EEDMEQASQS SWQEEDPKGQ QEQLPQVQKC ENHQAARSPA
1060 1070 1080 1090 1100
SMMSSEDLAP YLGESWKRKD SPQVPAEGVD DTSSSEGSTV DCPDPEEILR
1110 1120 1130 1140 1150
KIPELADDLD EPDDCFTEGC TRRCPCCNVN TSKSPWATGW QVRKTCYRIV
1160 1170 1180 1190 1200
EHSWFESFII FMILLSSGAL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF
1210 1220 1230 1240 1250
EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL
1260 1270 1280 1290 1300
RTLRALRPLR ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG
1310 1320 1330 1340 1350
VNLFAGKFSK CVDTRNNPFS NVNSTMVNNK SECHNQNSTG HFFWVNVKVN
1360 1370 1380 1390 1400
FDNVAMGYLA LLQVATFKGW MDIMYAAVDS GEINSQPNWE NNLYMYLYFV
1410 1420 1430 1440 1450
VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL
1460 1470 1480 1490 1500
GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMVLICLN MITMMVETDE
1510 1520 1530 1540 1550
QGEEKTKVLG RINQFFVAVF TGECVMKMFA LRQYYFTNGW NVFDFIVVIL
1560 1570 1580 1590 1600
SIGSLLFSAI LKSLENYFSP TLFRVIRLAR IGRILRLIRA AKGIRTLLFA
1610 1620 1630 1640 1650
LMMSLPALFN IGLLLFLVMF IYSIFGMASF ANVVDEAGID DMFNFKTFGN
1660 1670 1680 1690 1700
SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PNLPNSNGSR GNCGSPAVGI
1710 1720 1730 1740 1750
IFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED DFDMFYETWE
1760 1770 1780 1790 1800
KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH
1810 1820 1830 1840 1850
CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRWK
1860 1870 1880 1890 1900
QEDLSATVIQ KAYRSYMLHR SLTLSNTLHV PRAEEDGVSL PGEGYVTFMA
1910 1920 1930 1940 1950
NSGLPDKSET ASATSFPPSY DSVTRGLSDR ANINPSSSMQ NEDEVAAKEG

NSPGPQ
Length:1,956
Mass (Da):219,733
Last modified:November 1, 1996 - v1
Checksum:i8FC58EDAD263AC67
GO
Isoform 2 (identifier: Q62968-2) [UniParc]FASTAAdd to Basket

Also known as: Nav1.8c

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1030: Missing.

Show »
Length:1,955
Mass (Da):219,605
Checksum:i4C6677DF46388F43
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591A → D in CAA63095. (PubMed:8538791)Curated
Sequence conflicti432 – 4321A → E in CAA63095. (PubMed:8538791)Curated
Sequence conflicti520 – 5201T → TP in CAA63095. (PubMed:8538791)Curated
Sequence conflicti587 – 5871D → H in CAA63095. (PubMed:8538791)Curated
Sequence conflicti757 – 7571F → L in CAA63095. (PubMed:8538791)Curated
Sequence conflicti938 – 9381R → H in CAA63095. (PubMed:8538791)Curated
Sequence conflicti1896 – 18961V → I in CAA63095. (PubMed:8538791)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1030 – 10301Missing in isoform 2. 1 PublicationVSP_012258

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92184 mRNA. Translation: CAA63095.1.
U53833 Genomic DNA. Translation: AAC52619.1.
AJ623271 mRNA. Translation: CAF25041.1.
PIRiS68453.
RefSeqiNP_058943.1. NM_017247.1.
XP_008764895.1. XM_008766673.1. [Q62968-1]
UniGeneiRn.10246.

Genome annotation databases

GeneIDi29571.
KEGGirno:29571.
UCSCiRGD:3629. rat. [Q62968-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92184 mRNA. Translation: CAA63095.1.
U53833 Genomic DNA. Translation: AAC52619.1.
AJ623271 mRNA. Translation: CAF25041.1.
PIRiS68453.
RefSeqiNP_058943.1. NM_017247.1.
XP_008764895.1. XM_008766673.1. [Q62968-1]
UniGeneiRn.10246.

3D structure databases

ProteinModelPortaliQ62968.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62968. 23 interactions.

Chemistry

BindingDBiQ62968.
ChEMBLiCHEMBL4017.
GuidetoPHARMACOLOGYi585.

Protein family/group databases

TCDBi1.A.1.10.6. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteiQ62968.

Proteomic databases

PaxDbiQ62968.
PRIDEiQ62968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29571.
KEGGirno:29571.
UCSCiRGD:3629. rat. [Q62968-1]

Organism-specific databases

CTDi6336.
RGDi3629. Scn10a.

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ62968.
KOiK04842.
PhylomeDBiQ62968.
TreeFamiTF323985.

Miscellaneous databases

NextBioi609654.
PROiQ62968.

Gene expression databases

GenevestigatoriQ62968.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028809. Na_channel_a10su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF23. PTHR10037:SF23. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons."
    Akopian A.N., Sivilotti L., Wood J.N.
    Nature 379:257-262(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION.
    Tissue: Spinal ganglion.
  2. "Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons."
    Sangameswaran L., Delgado S.G., Fish L.M., Koch B.D., Jakeman L.B., Stewart G.R., Sze P., Hunter J.C., Eglen R.M., Herman R.C.
    J. Biol. Chem. 271:5953-5956(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION.
    Strain: Sprague-Dawley.
    Tissue: Spinal ganglion.
  3. "Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel."
    Vijayaragavan K., Powell A.J., Kinghorn I.J., Chahine M.
    Biochem. Biophys. Res. Commun. 319:531-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), INTERACTION WITH SCN1B; SCN2B AND SCN3B.
    Strain: Sprague-Dawley.
    Tissue: Spinal ganglion.
  4. "Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat."
    Kerr N.C.H., Holmes F.E., Wynick D.
    J. Biol. Chem. 279:24826-24833(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 963-1097 (ISOFORMS 1 AND 2).
    Strain: Wistar.
    Tissue: Spinal ganglion and Trigeminal ganglion.
  5. "Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia."
    Oaklander A.L., Belzberg A.J.
    Brain Res. Mol. Brain Res. 52:162-165(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. "Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons."
    Benn S.C., Costigan M., Tate S., Fitzgerald M., Woolf C.J.
    J. Neurosci. 21:6077-6085(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  7. "Annexin II light chain regulates sensory neuron-specific sodium channel expression."
    Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., Wood J.N.
    Nature 417:653-656(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH S100A10.
  8. "Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8."
    Malik-Hall M., Poon W.-Y.L., Baker M.D., Wood J.N., Okuse K.
    Brain Res. Mol. Brain Res. 110:298-304(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FSTL1; PRX; DYNLT1 AND PDZD2, IDENTIFICATION IN COMPLEXES WITH PRX; DYNLT1 AND PDZD2.
  9. "Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain."
    Gold M.S., Weinreich D., Kim C.-S., Wang R., Treanor J., Porreca F., Lai J.
    J. Neurosci. 23:158-166(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PAIN.

Entry informationi

Entry nameiSCNAA_RAT
AccessioniPrimary (citable) accession number: Q62968
Secondary accession number(s): Q63554, Q6EWG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.