Q62968 (SCNAA_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium channel protein type 10 subunit alpha

Alternative name(s):
Peripheral nerve sodium channel 3
Short name=PN3
Sensory neuron sodium channel
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8

Gene names

Name:	Scn10a
Synonyms:	Sns

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1956 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta regulatory auxiliary subunits (in vitro). Plays a role in neuropathic pain mechanisms. Ref.1 Ref.2 Ref.9
Subunit structure	The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L. Ref.3 Ref.7 Ref.8
Subcellular location	Membrane; Multi-pass membrane protein By similarity. Note: It can be translocated to the extracellular membrane through association with S100A10. Ref.7
Tissue specificity	Expressed in dorsal root ganglia, trigeminal ganglia, nodose ganglia and sciatic nerve. Ref.1 Ref.2 Ref.6
Developmental stage	Expressed in dorsal root ganglia at 15 dpc onwards. Ref.6
Induction	Down-regulated after axotomy in dorsal root ganglia. Ref.5
Domain	The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
Post-translational modification	Ubiquitinated by NEDD4L; which promotes its endocytosis By similarity.
Sequence similarities	Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. [View classification] Contains 1 IQ domain.

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Sodium
Molecular function	Ion channel Sodium channel Voltage-gated channel
PTM	Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	AV node cell to bundle of His cell communication Inferred from electronic annotation. Source: Compara bundle of His cell to Purkinje myocyte communication Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from expression pattern PubMed 21640979. Source: RGD regulation of atrial cardiac muscle cell membrane depolarization Inferred from electronic annotation. Source: Compara regulation of cardiac muscle contraction Inferred from electronic annotation. Source: Compara regulation of heart rate Inferred from electronic annotation. Source: Compara sensory perception of pain Inferred from mutant phenotype PubMed 21965668. Source: RGD
Cellular_component	clathrin complex Inferred from direct assay PubMed 15797711. Source: RGD integral to membrane Inferred from direct assay Ref.1. Source: RGD voltage-gated sodium channel complex Inferred from electronic annotation. Source: Compara
Molecular_function	voltage-gated sodium channel activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dynlt1	Q9Z336	2	EBI-1800320,EBI-920359
Prx	Q63425	2	EBI-1800320,EBI-1800492
S100a10	P05943	4	EBI-1800320,EBI-1800351

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q62968-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q62968-2)

Also known as: Nav1.8c;

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1030: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1956	1956	Sodium channel protein type 10 subunit alpha		PRO_0000048509
Regions
	Transmembrane	126 – 149	24	Helical; Name=S1 of repeat I; Potential
	Transmembrane	155 – 174	20	Helical; Name=S2 of repeat I; Potential
	Transmembrane	188 – 206	19	Helical; Name=S3 of repeat I; Potential
	Transmembrane	213 – 232	20	Helical; Voltage-sensor; Name=S4 of repeat I; Potential
	Transmembrane	249 – 272	24	Helical; Name=S5 of repeat I; Potential
	Transmembrane	373 – 398	26	Helical; Name=S6 of repeat I; Potential
	Transmembrane	659 – 683	25	Helical; Name=S1 of repeat II; Potential
	Transmembrane	695 – 718	24	Helical; Name=S2 of repeat II; Potential
	Transmembrane	727 – 746	20	Helical; Name=S3 of repeat II; Potential
	Transmembrane	753 – 772	20	Helical; Voltage-sensor; Name=S4 of repeat II; Potential
	Transmembrane	789 – 809	21	Helical; Name=S5 of repeat II; Potential
	Transmembrane	864 – 889	26	Helical; Name=S6 of repeat II; Potential
	Transmembrane	1149 – 1172	24	Helical; Name=S1 of repeat III; Potential
	Transmembrane	1186 – 1211	26	Helical; Name=S2 of repeat III; Potential
	Transmembrane	1218 – 1239	22	Helical; Name=S3 of repeat III; Potential
	Transmembrane	1244 – 1265	22	Helical; Voltage-sensor; Name=S4 of repeat III; Potential
	Transmembrane	1285 – 1312	28	Helical; Name=S5 of repeat III; Potential
	Transmembrane	1393 – 1419	27	Helical; Name=S6 of repeat III; Potential
	Transmembrane	1473 – 1496	24	Helical; Name=S1 of repeat IV; Potential
	Transmembrane	1508 – 1531	24	Helical; Name=S2 of repeat IV; Potential
	Transmembrane	1538 – 1561	24	Helical; Name=S3 of repeat IV; Potential
	Transmembrane	1574 – 1595	22	Helical; Voltage-sensor; Name=S4 of repeat IV; Potential
	Transmembrane	1611 – 1633	23	Helical; Name=S5 of repeat IV; Potential
	Transmembrane	1699 – 1723	25	Helical; Name=S6 of repeat IV; Potential
	Repeat	125 – 399	275	I
	Repeat	658 – 890	233	II
	Repeat	1148 – 1420	273	III
	Repeat	1472 – 1724	253	IV
	Domain	1852 – 1881	30	IQ
Amino acid modifications
	Glycosylation	279	1	N-linked (GlcNAc...) Potential
	Glycosylation	288	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential
	Glycosylation	334	1	N-linked (GlcNAc...) Potential
	Glycosylation	1323	1	N-linked (GlcNAc...) Potential
	Glycosylation	1329	1	N-linked (GlcNAc...) Potential
	Glycosylation	1337	1	N-linked (GlcNAc...) Potential
	Glycosylation	1687	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1030	1	Missing in isoform 2.		VSP_012258
Experimental info
	Sequence conflict	59	1	A → D in CAA63095. Ref.1
	Sequence conflict	432	1	A → E in CAA63095. Ref.1
	Sequence conflict	520	1	T → TP in CAA63095. Ref.1
	Sequence conflict	587	1	D → H in CAA63095. Ref.1
	Sequence conflict	757	1	F → L in CAA63095. Ref.1
	Sequence conflict	938	1	R → H in CAA63095. Ref.1
	Sequence conflict	1896	1	V → I in CAA63095. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8FC58EDAD263AC67	FASTA	1,956	219,733
	10 20 30 40 50 60 MELPFASVGT TNFRRFTPES LAEIEKQIAA HRAAKKARTK HRGQEDKGEK PRPQLDLKAC 70 80 90 100 110 120 NQLPKFYGEL PAELVGEPLE DLDPFYSTHR TFMVLNKSRT ISRFSATWAL WLFSPFNLIR 130 140 150 160 170 180 RTAIKVSVHS WFSIFITITI LVNCVCMTRT DLPEKVEYVF TVIYTFEALI KILARGFCLN 190 200 210 220 230 240 EFTYLRDPWN WLDFSVITLA YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI 250 260 270 280 290 300 HSVRKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCIRNG TDPHKADNLS SEMAEYIFIK 310 320 330 340 350 360 PGTTDPLLCG NGSDAGHCPG GYVCLKTPDN PDFNYTSFDS FAWAFLSLFR LMTQDSWERL 370 380 390 400 410 420 YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE EQSQATIAEI EAKEKKFQEA 430 440 450 460 470 480 LEVLQKEQEV LAALGIDTTS LQSHSGSPLA SKNANERRPR VKSRVSEGST DDNRSPQSDP 490 500 510 520 530 540 YNQRRMSFLG LSSGRRRASH GSVFHFRAPS QDISFPDGIT DDGVFHGDQE SRRGSILLGR 550 560 570 580 590 600 GAGQTGPLPR SPLPQSPNPG RRHGEEGQLG VPTGELTAGA PEGPALDTTG QKSFLSAGYL 610 620 630 640 650 660 NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISFAQK YLIWECCPKW RKFKMALFEL 670 680 690 700 710 720 VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN IVFTVFFTME MAFKIIAFDP 730 740 750 760 770 780 YYYFQKKWNI FDCVIVTVSL LELSASKKGS LSVLRTFRLL RVFKLAKSWP TLNTLIKIIG 790 800 810 820 830 840 NSVGALGNLT FILAIIVFIF ALVGKQLLSE DYGCRKDGVS VWNGEKLRWH MCDFFHSFLV 850 860 870 880 890 900 VFRILCGEWI ENMWVCMEVS QKSICLILFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP 910 920 930 940 950 960 EDDGEVNNLQ LALARIQVLG HRASRAIASY ISSHCRFRWP KVETQLGMKP PLTSSEAKNH 970 980 990 1000 1010 1020 IATDAVSAAV GNLTKPALSS PKENHGDFIT DPNVWVSVPI AEGESDLDEL EEDMEQASQS 1030 1040 1050 1060 1070 1080 SWQEEDPKGQ QEQLPQVQKC ENHQAARSPA SMMSSEDLAP YLGESWKRKD SPQVPAEGVD 1090 1100 1110 1120 1130 1140 DTSSSEGSTV DCPDPEEILR KIPELADDLD EPDDCFTEGC TRRCPCCNVN TSKSPWATGW 1150 1160 1170 1180 1190 1200 QVRKTCYRIV EHSWFESFII FMILLSSGAL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF 1210 1220 1230 1240 1250 1260 EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL RTLRALRPLR 1270 1280 1290 1300 1310 1320 ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKFSK CVDTRNNPFS 1330 1340 1350 1360 1370 1380 NVNSTMVNNK SECHNQNSTG HFFWVNVKVN FDNVAMGYLA LLQVATFKGW MDIMYAAVDS 1390 1400 1410 1420 1430 1440 GEINSQPNWE NNLYMYLYFV VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ 1450 1460 1470 1480 1490 1500 KKYYNAMKKL GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMVLICLN MITMMVETDE 1510 1520 1530 1540 1550 1560 QGEEKTKVLG RINQFFVAVF TGECVMKMFA LRQYYFTNGW NVFDFIVVIL SIGSLLFSAI 1570 1580 1590 1600 1610 1620 LKSLENYFSP TLFRVIRLAR IGRILRLIRA AKGIRTLLFA LMMSLPALFN IGLLLFLVMF 1630 1640 1650 1660 1670 1680 IYSIFGMASF ANVVDEAGID DMFNFKTFGN SMLCLFQITT SAGWDGLLSP ILNTGPPYCD 1690 1700 1710 1720 1730 1740 PNLPNSNGSR GNCGSPAVGI IFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED 1750 1760 1770 1780 1790 1800 DFDMFYETWE KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH 1810 1820 1830 1840 1850 1860 CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRWK QEDLSATVIQ 1870 1880 1890 1900 1910 1920 KAYRSYMLHR SLTLSNTLHV PRAEEDGVSL PGEGYVTFMA NSGLPDKSET ASATSFPPSY 1930 1940 1950 DSVTRGLSDR ANINPSSSMQ NEDEVAAKEG NSPGPQ
	Isoform 2 (Nav1.8c) [UniParc]. Checksum: 4C6677DF46388F43	FASTA	1,955	219,605
	10 20 30 40 50 60 MELPFASVGT TNFRRFTPES LAEIEKQIAA HRAAKKARTK HRGQEDKGEK PRPQLDLKAC 70 80 90 100 110 120 NQLPKFYGEL PAELVGEPLE DLDPFYSTHR TFMVLNKSRT ISRFSATWAL WLFSPFNLIR 130 140 150 160 170 180 RTAIKVSVHS WFSIFITITI LVNCVCMTRT DLPEKVEYVF TVIYTFEALI KILARGFCLN 190 200 210 220 230 240 EFTYLRDPWN WLDFSVITLA YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI 250 260 270 280 290 300 HSVRKLADVT ILTVFCLSVF ALVGLQLFKG NLKNKCIRNG TDPHKADNLS SEMAEYIFIK 310 320 330 340 350 360 PGTTDPLLCG NGSDAGHCPG GYVCLKTPDN PDFNYTSFDS FAWAFLSLFR LMTQDSWERL 370 380 390 400 410 420 YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE EQSQATIAEI EAKEKKFQEA 430 440 450 460 470 480 LEVLQKEQEV LAALGIDTTS LQSHSGSPLA SKNANERRPR VKSRVSEGST DDNRSPQSDP 490 500 510 520 530 540 YNQRRMSFLG LSSGRRRASH GSVFHFRAPS QDISFPDGIT DDGVFHGDQE SRRGSILLGR 550 560 570 580 590 600 GAGQTGPLPR SPLPQSPNPG RRHGEEGQLG VPTGELTAGA PEGPALDTTG QKSFLSAGYL 610 620 630 640 650 660 NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISFAQK YLIWECCPKW RKFKMALFEL 670 680 690 700 710 720 VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN IVFTVFFTME MAFKIIAFDP 730 740 750 760 770 780 YYYFQKKWNI FDCVIVTVSL LELSASKKGS LSVLRTFRLL RVFKLAKSWP TLNTLIKIIG 790 800 810 820 830 840 NSVGALGNLT FILAIIVFIF ALVGKQLLSE DYGCRKDGVS VWNGEKLRWH MCDFFHSFLV 850 860 870 880 890 900 VFRILCGEWI ENMWVCMEVS QKSICLILFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP 910 920 930 940 950 960 EDDGEVNNLQ LALARIQVLG HRASRAIASY ISSHCRFRWP KVETQLGMKP PLTSSEAKNH 970 980 990 1000 1010 1020 IATDAVSAAV GNLTKPALSS PKENHGDFIT DPNVWVSVPI AEGESDLDEL EEDMEQASQS 1030 1040 1050 1060 1070 1080 SWQEEDPKGQ EQLPQVQKCE NHQAARSPAS MMSSEDLAPY LGESWKRKDS PQVPAEGVDD 1090 1100 1110 1120 1130 1140 TSSSEGSTVD CPDPEEILRK IPELADDLDE PDDCFTEGCT RRCPCCNVNT SKSPWATGWQ 1150 1160 1170 1180 1190 1200 VRKTCYRIVE HSWFESFIIF MILLSSGALA FEDNYLEEKP RVKSVLEYTD RVFTFIFVFE 1210 1220 1230 1240 1250 1260 MLLKWVAYGF KKYFTNAWCW LDFLIVNISL TSLIAKILEY SDVASIKALR TLRALRPLRA 1270 1280 1290 1300 1310 1320 LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFSKC VDTRNNPFSN 1330 1340 1350 1360 1370 1380 VNSTMVNNKS ECHNQNSTGH FFWVNVKVNF DNVAMGYLAL LQVATFKGWM DIMYAAVDSG 1390 1400 1410 1420 1430 1440 EINSQPNWEN NLYMYLYFVV FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK 1450 1460 1470 1480 1490 1500 KYYNAMKKLG SKKPQKPIPR PLNKYQGFVF DIVTRQAFDI IIMVLICLNM ITMMVETDEQ 1510 1520 1530 1540 1550 1560 GEEKTKVLGR INQFFVAVFT GECVMKMFAL RQYYFTNGWN VFDFIVVILS IGSLLFSAIL 1570 1580 1590 1600 1610 1620 KSLENYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI 1630 1640 1650 1660 1670 1680 YSIFGMASFA NVVDEAGIDD MFNFKTFGNS MLCLFQITTS AGWDGLLSPI LNTGPPYCDP 1690 1700 1710 1720 1730 1740 NLPNSNGSRG NCGSPAVGII FFTTYIIISF LIVVNMYIAV ILENFNVATE ESTEPLSEDD 1750 1760 1770 1780 1790 1800 FDMFYETWEK FDPEATQFIA FSALSDFADT LSGPLRIPKP NQNILIQMDL PLVPGDKIHC 1810 1820 1830 1840 1850 1860 LDILFAFTKN VLGESGELDS LKTNMEEKFM ATNLSKASYE PIATTLRWKQ EDLSATVIQK 1870 1880 1890 1900 1910 1920 AYRSYMLHRS LTLSNTLHVP RAEEDGVSLP GEGYVTFMAN SGLPDKSETA SATSFPPSYD 1930 1940 1950 SVTRGLSDRA NINPSSSMQN EDEVAAKEGN SPGPQ

References

[1]	"A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons." Akopian A.N., Sivilotti L., Wood J.N. Nature 379:257-262(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION. Tissue: Spinal ganglion.
[2]	"Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons." Sangameswaran L., Delgado S.G., Fish L.M., Koch B.D., Jakeman L.B., Stewart G.R., Sze P., Hunter J.C., Eglen R.M., Herman R.C. J. Biol. Chem. 271:5953-5956(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY, FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION. Strain: Sprague-Dawley. Tissue: Spinal ganglion.
[3]	"Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel." Vijayaragavan K., Powell A.J., Kinghorn I.J., Chahine M. Biochem. Biophys. Res. Commun. 319:531-540(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), INTERACTION WITH SCN1B; SCN2B AND SCN3B. Strain: Sprague-Dawley. Tissue: Spinal ganglion.
[4]	"Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat." Kerr N.C.H., Holmes F.E., Wynick D. J. Biol. Chem. 279:24826-24833(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 963-1097 (ISOFORMS 1 AND 2). Strain: Wistar. Tissue: Spinal ganglion and Trigeminal ganglion.
[5]	"Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia." Oaklander A.L., Belzberg A.J. Brain Res. Mol. Brain Res. 52:162-165(1997) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[6]	"Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons." Benn S.C., Costigan M., Tate S., Fitzgerald M., Woolf C.J. J. Neurosci. 21:6077-6085(2001) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[7]	"Annexin II light chain regulates sensory neuron-specific sodium channel expression." Okuse K., Malik-Hall M., Baker M.D., Poon W.-Y.L., Kong H., Chao M.V., Wood J.N. Nature 417:653-656(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH S100A10.
[8]	"Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8." Malik-Hall M., Poon W.-Y.L., Baker M.D., Wood J.N., Okuse K. Brain Res. Mol. Brain Res. 110:298-304(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FSTL1; PRX; DYNLT1 AND PDZD2, IDENTIFICATION IN COMPLEXES WITH PRX; DYNLT1 AND PDZD2.
[9]	"Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain." Gold M.S., Weinreich D., Kim C.-S., Wang R., Treanor J., Porreca F., Lai J. J. Neurosci. 23:158-166(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN PAIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X92184 mRNA. Translation: CAA63095.1. U53833 Genomic DNA. Translation: AAC52619.1. AJ623271 mRNA. Translation: CAF25041.1.
IPI	IPI00210089. IPI00515844.
PIR	S68453.
RefSeq	NP_058943.1. NM_017247.1.
UniGene	Rn.10246.
3D structure databases
ProteinModelPortal	Q62968.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q62968. 23 interactions.
Protein family/group databases
TCDB	1.A.1.10.6. voltage-gated ion channel (VIC) superfamily.
PTM databases
PhosphoSite	Q62968.
Proteomic databases
PaxDb	Q62968.
PRIDE	Q62968.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	29571.
KEGG	rno:29571.
UCSC	RGD:3629. rat.
Organism-specific databases
CTD	6336.
RGD	3629. Scn10a.
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231755.
HOVERGEN	HBG053100.
InParanoid	Q62968.
KO	K04842.
OrthoDB	EOG4229HT.
Gene expression databases
ArrayExpress	Q62968.
Genevestigator	Q62968.
GermOnline	ENSRNOG00000032473. Rattus norvegicus.
Family and domain databases
Gene3D	1.20.120.350. 4 hits.
InterPro	IPR005821. Ion_trans_dom. IPR027359. K_channel_four-helix_dom. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. [Graphical view]
Pfam	PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL.
PROSITE	PS50096. IQ. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q62968.
ChEMBL	CHEMBL4017.
NextBio	609654.

Entry information

Entry name

SCNAA_RAT

Accession

Primary (citable) accession number: Q62968
Secondary accession number(s): Q63554, Q6EWG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program