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Protein

Diphosphomevalonate decarboxylase

Gene

Mvd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Performs the first committed step in the biosynthesis of isoprenes.

Catalytic activityi

ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2.

Pathwayi: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • diphosphomevalonate decarboxylase activity Source: RGD

GO - Biological processi

  • cholesterol biosynthetic process Source: RGD
  • isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: RGD
  • response to drug Source: RGD

Keywordsi

Molecular functionLyase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.1.1.33 5301
SABIO-RKiQ62967
UniPathwayiUPA00063

Names & Taxonomyi

Protein namesi
Recommended name:
Diphosphomevalonate decarboxylase (EC:4.1.1.33)
Alternative name(s):
Mevalonate (diphospho)decarboxylase
Short name:
MDDase
Mevalonate pyrophosphate decarboxylase
Gene namesi
Name:Mvd
Synonyms:Mpd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621292 Mvd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi642

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000870142 – 401Diphosphomevalonate decarboxylaseAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ62967
PRIDEiQ62967

PTM databases

iPTMnetiQ62967
PhosphoSitePlusiQ62967

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018145

Structurei

3D structure databases

ProteinModelPortaliQ62967
SMRiQ62967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 54Poly-Thr4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2833 Eukaryota
COG3407 LUCA
HOVERGENiHBG051503
InParanoidiQ62967
KOiK01597
PhylomeDBiQ62967

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
InterProiView protein in InterPro
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR005935 Mev_decarb
IPR029765 Mev_diP_decarb
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF015950 Mev_P_decrbx, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR01240 mevDPdecarb, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEKPQDLM VTCTAPVNIA VIKYWGKRDE ALILPINPSL SVTLHQDQLK
60 70 80 90 100
TTTTAAISKD FTEDRIWLNG REEDVGQPRL QACLREIRRL ARKRRSTGDG
110 120 130 140 150
DALPLSLGYK VHVASVNNFP TAAGLASSAA GYACLAYTLA RVYGVEGDLS
160 170 180 190 200
EVARRGSGSA CRSLYGGFVE WQMGEQADGK DSIARQIAPE WHWPQLRVLI
210 220 230 240 250
LVVSAEKKPT GSTVGMQTSV ATSTLLKFRA ESIVPERMKE MTRCIQEQDF
260 270 280 290 300
QAFAQLTMKD SNQFHATCLD TFPPISYLND TSRRIIQLVH RFNAHHGQTK
310 320 330 340 350
VAYTFDAGPN AVIFTLEDTV AEFVAAVRHS FPPAANGDKF LKGLQVAPVL
360 370 380 390 400
LSDELKTSLA TEPSPGGVQY IIATQVGPGP QVLDDPHHHL LGPDGLPQRD

L
Length:401
Mass (Da):43,903
Last modified:November 1, 1997 - v1
Checksum:i6DC17437C170A645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53706 mRNA Translation: AAB00192.1
RefSeqiNP_112324.1, NM_031062.2
UniGeneiRn.10288

Genome annotation databases

GeneIDi81726
KEGGirno:81726
UCSCiRGD:621292 rat

Similar proteinsi

Entry informationi

Entry nameiMVD1_RAT
AccessioniPrimary (citable) accession number: Q62967
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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