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Protein

Dihydropyrimidinase-related protein 4

Gene

Dpysl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • neuron death Source: InterPro
  • neuron development Source: RGD
  • neuron projection guidance Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiM38.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 4
Short name:
DRP-4
Alternative name(s):
Collapsin response mediator protein 3
Short name:
CRMP-3
UNC33-like phosphoprotein 4
Short name:
ULIP-4
Gene namesi
Name:Dpysl4
Synonyms:Crmp3, Ulip4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2409. Dpysl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 564›564Dihydropyrimidinase-related protein 4PRO_0000165923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei529 – 5291PhosphoserineBy similarity
Modified residuei536 – 5361PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62951.
PRIDEiQ62951.

PTM databases

iPTMnetiQ62951.
PhosphoSiteiQ62951.

Expressioni

Developmental stagei

Expressed transiently in developing spinal cord and selectively in the postnatal cerebellum.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247452. 1 interaction.
STRINGi10116.ENSRNOP00000029334.

Structurei

3D structure databases

ProteinModelPortaliQ62951.
SMRiQ62951. Positions 7-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ62951.
PhylomeDBiQ62951.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030612. DRP4.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF55. PTHR11647:SF55. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q62951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IPRITSDRLL IKGGKIVNDD QSFHADLYVE DGLIKQIGEN LIVPGGIKTI
60 70 80 90 100
DAHGLMVLPG GVDVHTRLQM PVLGMTPADD FCQGTKAALA GGTTMILDHV
110 120 130 140 150
FPDAGVSLLA AYEQWRERAD SAACCDYSLH VDIPRWHEST KEELEALVRD
160 170 180 190 200
KGVNSFLVFM AYKDRCQCTD GQIYEIFSLI RDLGAVAQVH AENGDIVEEE
210 220 230 240 250
QKRLLEQGIT GPEGHVLSHP EEVEAEAVYR AVTIAKQANC PLYITKVMSK
260 270 280 290 300
GAADMVAQAK RRGVVVFGEP ITASLGTDGS HYWSKNWAKA AAFVTSPPIN
310 320 330 340 350
PDPTTADHLT SLLSSGDLQV TGSAHCTFTT AQKAVGKDNF TLIPEGINGI
360 370 380 390 400
EERMSVVWEK CVASGKMDEN EFVAVTSTNA AKIFNFYPRK GRVAVGSDAD
410 420 430 440 450
LVIWNPRATK VISAKSHNLN VEYNIFEGVE CRGMPTVVIS QGRVVLEDGN
460 470 480 490 500
LLVTPGAGRF IPRKTFPDFV YKRIKARNRL AEIHGVPRGL YDGPVHEVML
510 520 530 540 550
PAKPGSGTQA RASCPGKISV PPVRNLHQSG FSLSGSQADD HIARRTAQKI
560
MAPPGGRSNI TSLS
Length:564
Mass (Da):61,086
Last modified:November 1, 1996 - v1
Checksum:i42050891CC1436D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52103 mRNA. Translation: AAB03281.1.
RefSeqiNP_037065.1. NM_012933.1.
UniGeneiRn.10503.

Genome annotation databases

GeneIDi25417.
KEGGirno:25417.
UCSCiRGD:2409. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52103 mRNA. Translation: AAB03281.1.
RefSeqiNP_037065.1. NM_012933.1.
UniGeneiRn.10503.

3D structure databases

ProteinModelPortaliQ62951.
SMRiQ62951. Positions 7-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247452. 1 interaction.
STRINGi10116.ENSRNOP00000029334.

Protein family/group databases

MEROPSiM38.977.

PTM databases

iPTMnetiQ62951.
PhosphoSiteiQ62951.

Proteomic databases

PaxDbiQ62951.
PRIDEiQ62951.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25417.
KEGGirno:25417.
UCSCiRGD:2409. rat.

Organism-specific databases

CTDi10570.
RGDi2409. Dpysl4.

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ62951.
PhylomeDBiQ62951.

Miscellaneous databases

NextBioi606565.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030612. DRP4.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF55. PTHR11647:SF55. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A family of rat CRMP genes is differentially expressed in the nervous system."
    Wang L., Strittmatter S.M.
    J. Neurosci. 16:6197-6207(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Lubec G., Diao W., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 36-48; 119-149; 166-181; 263-285; 338-353; 367-382; 416-432 AND 489-511, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain and Hippocampus.

Entry informationi

Entry nameiDPYL4_RAT
AccessioniPrimary (citable) accession number: Q62951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.