Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydropyrimidinase-related protein 4

Gene

Dpysl4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • neuron death Source: InterPro
  • neuron development Source: RGD
  • neuron projection guidance Source: InterPro

Protein family/group databases

MEROPSiM38.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 4
Short name:
DRP-4
Alternative name(s):
Collapsin response mediator protein 3
Short name:
CRMP-3
UNC33-like phosphoprotein 4
Short name:
ULIP-4
Gene namesi
Name:Dpysl4
Synonyms:Crmp3, Ulip4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2409. Dpysl4.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000165923‹1 – 564Dihydropyrimidinase-related protein 4Add BLAST›564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei529PhosphoserineBy similarity1
Modified residuei536PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62951.
PRIDEiQ62951.

PTM databases

iPTMnetiQ62951.
PhosphoSitePlusiQ62951.

Expressioni

Developmental stagei

Expressed transiently in developing spinal cord and selectively in the postnatal cerebellum.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL3 or DPYSL5. Interacts with PLEXA1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi247452. 1 interactor.
STRINGi10116.ENSRNOP00000029334.

Structurei

3D structure databases

ProteinModelPortaliQ62951.
SMRiQ62951.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ62951.
PhylomeDBiQ62951.

Family and domain databases

CDDicd01314. D-HYD. 1 hit.
Gene3Di2.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR006680. Amidohydro-rel.
IPR030612. DRP4.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
PANTHERiPTHR11647:SF55. PTHR11647:SF55. 1 hit.
PfamiView protein in Pfam
PF01979. Amidohydro_1. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q62951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IPRITSDRLL IKGGKIVNDD QSFHADLYVE DGLIKQIGEN LIVPGGIKTI
60 70 80 90 100
DAHGLMVLPG GVDVHTRLQM PVLGMTPADD FCQGTKAALA GGTTMILDHV
110 120 130 140 150
FPDAGVSLLA AYEQWRERAD SAACCDYSLH VDIPRWHEST KEELEALVRD
160 170 180 190 200
KGVNSFLVFM AYKDRCQCTD GQIYEIFSLI RDLGAVAQVH AENGDIVEEE
210 220 230 240 250
QKRLLEQGIT GPEGHVLSHP EEVEAEAVYR AVTIAKQANC PLYITKVMSK
260 270 280 290 300
GAADMVAQAK RRGVVVFGEP ITASLGTDGS HYWSKNWAKA AAFVTSPPIN
310 320 330 340 350
PDPTTADHLT SLLSSGDLQV TGSAHCTFTT AQKAVGKDNF TLIPEGINGI
360 370 380 390 400
EERMSVVWEK CVASGKMDEN EFVAVTSTNA AKIFNFYPRK GRVAVGSDAD
410 420 430 440 450
LVIWNPRATK VISAKSHNLN VEYNIFEGVE CRGMPTVVIS QGRVVLEDGN
460 470 480 490 500
LLVTPGAGRF IPRKTFPDFV YKRIKARNRL AEIHGVPRGL YDGPVHEVML
510 520 530 540 550
PAKPGSGTQA RASCPGKISV PPVRNLHQSG FSLSGSQADD HIARRTAQKI
560
MAPPGGRSNI TSLS
Length:564
Mass (Da):61,086
Last modified:November 1, 1996 - v1
Checksum:i42050891CC1436D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52103 mRNA. Translation: AAB03281.1.
RefSeqiNP_037065.1. NM_012933.1.
UniGeneiRn.10503.

Genome annotation databases

GeneIDi25417.
KEGGirno:25417.
UCSCiRGD:2409. rat.

Similar proteinsi

Entry informationi

Entry nameiDPYL4_RAT
AccessioniPrimary (citable) accession number: Q62951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families