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Protein

Dihydropyrimidinase-related protein 1

Gene

Crmp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis (By similarity).By similarity

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-399956 CRMPs in Sema3A signaling

Protein family/group databases

MEROPSiM38.974

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 1
Short name:
DRP-1
Alternative name(s):
Collapsin response mediator protein 1
Short name:
CRMP-1
Gene namesi
Name:Crmp1
Synonyms:Dpysl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2407 Crmp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659111 – 572Dihydropyrimidinase-related protein 1Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei32PhosphotyrosineBy similarity1
Modified residuei101PhosphothreonineBy similarity1
Modified residuei102PhosphothreonineBy similarity1
Modified residuei258N6-succinyllysineBy similarity1
Modified residuei259PhosphoserineBy similarity1
Modified residuei316Nitrated tyrosineBy similarity1
Modified residuei431PhosphotyrosineBy similarity1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei504PhosphotyrosineBy similarity1
Modified residuei509PhosphothreonineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei521PhosphoserineCombined sources1
Modified residuei522PhosphoserineCombined sources1
Modified residuei537PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1
Modified residuei565Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

PaxDbiQ62950
PRIDEiQ62950

2D gel databases

World-2DPAGEi0004:Q62950

PTM databases

iPTMnetiQ62950
PhosphoSitePlusiQ62950

Expressioni

Gene expression databases

BgeeiENSRNOG00000004781
GenevisibleiQ62950 RN

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By similarity).By similarity

GO - Molecular functioni

  • filamin binding Source: WormBase
  • phosphoprotein binding Source: RGD

Protein-protein interaction databases

BioGridi2474503 interactors.
IntActiQ62950 2 interactors.
MINTiQ62950
STRINGi10116.ENSRNOP00000063671

Structurei

3D structure databases

ProteinModelPortaliQ62950
SMRiQ62950
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ62950
OMAiPEYLYQR
OrthoDBiEOG091G05F3
PhylomeDBiQ62950

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.102 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030624 CRMP1
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF54 PTHR11647:SF54, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q62950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQGKKSIP HITSDRLLIR GGRIINDDQS FYADVYLEDG LIKQIGENLI
60 70 80 90 100
VPGGVKTIEA NGRMVIPGGI DVNTYLQKPS QGMTSADDFF QGTRAALAGG
110 120 130 140 150
TTMIIDHVVP EPGSSLLTSF EKWHEAADTK SCCDYSLHVD ITSWYDGVRE
160 170 180 190 200
ELEVLVQDKG VNSFQVYMAY KDLYQMSDSQ LYEAFTFLKG LGAVILVHAE
210 220 230 240 250
NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI AIAGRINCPV
260 270 280 290 300
YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL
360 370 380 390 400
IPEGVNGIEE RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR
410 420 430 440 450
IAVGSDADVV IWDPDKMKTL TAKSHKSTVE YNIFEGMECH GSPLVVISQG
460 470 480 490 500
KIVFEDGNIS VSKGMGRFIP RKPFPEHLYQ RVRIRSKVFG LHSVSRGMYD
510 520 530 540 550
GPVYEVPATP KHAAPAPSAK SSPSKHQPPP IRNLHQSNFS LSGAQIDDNN
560 570
PRRTGHRIVA PPGGRSNITS LG
Length:572
Mass (Da):62,196
Last modified:November 1, 1996 - v1
Checksum:iED63BD8C751CCFDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3H → Y in AAB07042 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52102 mRNA Translation: AAB03280.1
U52095 mRNA Translation: AAB07042.1
RefSeqiNP_037064.1, NM_012932.2
UniGeneiRn.11379

Genome annotation databases

EnsembliENSRNOT00000065334; ENSRNOP00000063671; ENSRNOG00000004781
GeneIDi25415
KEGGirno:25415

Similar proteinsi

Entry informationi

Entry nameiDPYL1_RAT
AccessioniPrimary (citable) accession number: Q62950
Secondary accession number(s): P70546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome