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Protein

Cortistatin

Gene

Cort

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Neuropeptide with neuronal depressant and sleep-modulating properties.

GO - Molecular functioni

  • neuropeptide hormone activity Source: RGD

GO - Biological processi

  • neuropeptide signaling pathway Source: RGD
  • regulation of circadian sleep/wake cycle, sleep Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Cortistatin
Cleaved into the following 2 chains:
Gene namesi
Name:Cort
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2383. Cort.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Propeptidei28 – 8154Sequence analysisPRO_0000033159Add
BLAST
Peptidei84 – 11229Cortistatin-29Sequence analysisPRO_0000033160Add
BLAST
Peptidei99 – 11214Cortistatin-14PRO_0000033161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi100 ↔ 111By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ62949.

Expressioni

Tissue specificityi

Interneurons in the cerebral cortex and hyppocampus.

Developmental stagei

There is a transient increase in cortistatin-expressing cells in the second postnatal week in all cortical areas and in the dentate gyrus. A transient expression is observed in the hilar region at P16.

Interactioni

GO - Molecular functioni

  • neuropeptide hormone activity Source: RGD

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG017816.
KOiK05238.
PhylomeDBiQ62949.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGCSTRGKR PSALSLLLLL LLSGIAASAL PLESGPTGQD SVQDATGGRR
60 70 80 90 100
TGLLTFLAWW HEWASQDSSS TAFEGGTPEL SKRQERPPLQ QPPHRDKKPC
110
KNFFWKTFSS CK
Length:112
Mass (Da):12,201
Last modified:November 1, 1996 - v1
Checksum:iFF1FBFC76CBD7991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51919 mRNA. Translation: AAC52585.1.
PIRiS67489.
RefSeqiNP_036967.1. NM_012835.1.
UniGeneiRn.10490.

Genome annotation databases

GeneIDi25305.
KEGGirno:25305.
UCSCiRGD:2383. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51919 mRNA. Translation: AAC52585.1.
PIRiS67489.
RefSeqiNP_036967.1. NM_012835.1.
UniGeneiRn.10490.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ62949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25305.
KEGGirno:25305.
UCSCiRGD:2383. rat.

Organism-specific databases

CTDi1325.
RGDi2383. Cort.

Phylogenomic databases

HOVERGENiHBG017816.
KOiK05238.
PhylomeDBiQ62949.

Miscellaneous databases

NextBioi606097.
PROiQ62949.

Family and domain databases

InterProiIPR004250. Somatostatin.
IPR018142. Somatostatin/Cortistatin_C.
[Graphical view]
PfamiPF03002. Somatostatin. 1 hit.
[Graphical view]
PIRSFiPIRSF001814. Somatostatin. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 99-112.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCORT_RAT
AccessioniPrimary (citable) accession number: Q62949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.