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Protein

Melanoma-derived growth regulatory protein

Gene

Mia

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function during cartilage development and maintenance.

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-derived growth regulatory protein
Alternative name(s):
Cartilage-derived retinoic acid-sensitive protein
Short name:
CD-RAP
Melanoma inhibitory activity protein
Gene namesi
Name:Mia
Synonyms:Cdrap, Mia1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620883. Mia.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 130108Melanoma-derived growth regulatory proteinPRO_0000019030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 40By similarity
Disulfide bondi58 ↔ 129By similarity

Post-translational modificationi

May possess two intramolecular disulfide bonds.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62946.

Expressioni

Tissue specificityi

Cartilage primordia and cartilage.

Inductioni

Repressed by retinoic acid.

Gene expression databases

BgeeiENSRNOG00000001499.
GenevisibleiQ62946. RN.

Interactioni

Subunit structurei

Interacts with FASLG.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002050.

Structurei

3D structure databases

ProteinModelPortaliQ62946.
SMRiQ62946. Positions 26-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11271SH3Add
BLAST

Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated
Contains 1 SH3 domain.Curated

Keywords - Domaini

SH3 domain, Signal

Phylogenomic databases

eggNOGiENOG410IVZ6. Eukaryota.
ENOG411207U. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ62946.
KOiK16655.
OMAiFIPIRQG.
OrthoDBiEOG091G0RVX.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCSPVLLGI VILSVFSGLS RADRAMPKLA DRKLCADEEC SHPISMAVAL
60 70 80 90 100
QDYVAPDCRF LTIYRGQVVY VFSKLKGRGR LFWGGSVQGD YYGDLAAHLG
110 120 130
YFPSSIVRED LTLKPGKVDM KTDEWDFYCQ
Length:130
Mass (Da):14,536
Last modified:February 21, 2001 - v2
Checksum:i5F99149AECF74501
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 472MA → VT in AAC52481 (PubMed:8621736).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51438 mRNA. Translation: AAC52481.1.
U67884 mRNA. Translation: AAB40659.1.
RefSeqiNP_110479.1. NM_030852.2.
UniGeneiRn.10660.

Genome annotation databases

EnsembliENSRNOT00000002050; ENSRNOP00000002050; ENSRNOG00000001499.
GeneIDi81510.
KEGGirno:81510.
UCSCiRGD:620883. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51438 mRNA. Translation: AAC52481.1.
U67884 mRNA. Translation: AAB40659.1.
RefSeqiNP_110479.1. NM_030852.2.
UniGeneiRn.10660.

3D structure databases

ProteinModelPortaliQ62946.
SMRiQ62946. Positions 26-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002050.

Proteomic databases

PaxDbiQ62946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002050; ENSRNOP00000002050; ENSRNOG00000001499.
GeneIDi81510.
KEGGirno:81510.
UCSCiRGD:620883. rat.

Organism-specific databases

CTDi8190.
RGDi620883. Mia.

Phylogenomic databases

eggNOGiENOG410IVZ6. Eukaryota.
ENOG411207U. LUCA.
GeneTreeiENSGT00390000010535.
HOGENOMiHOG000063668.
HOVERGENiHBG000503.
InParanoidiQ62946.
KOiK16655.
OMAiFIPIRQG.
OrthoDBiEOG091G0RVX.

Miscellaneous databases

PROiQ62946.

Gene expression databases

BgeeiENSRNOG00000001499.
GenevisibleiQ62946. RN.

Family and domain databases

InterProiIPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMIA_RAT
AccessioniPrimary (citable) accession number: Q62946
Secondary accession number(s): P97591
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.