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Protein

Melanoma-derived growth regulatory protein

Gene

Mia

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function during cartilage development and maintenance.

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-derived growth regulatory protein
Alternative name(s):
Cartilage-derived retinoic acid-sensitive protein
Short name:
CD-RAP
Melanoma inhibitory activity protein
Gene namesi
Name:Mia
Synonyms:Cdrap, Mia1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620883 Mia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001903023 – 130Melanoma-derived growth regulatory proteinAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 40By similarity
Disulfide bondi58 ↔ 129By similarity

Post-translational modificationi

May possess two intramolecular disulfide bonds.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62946

Expressioni

Tissue specificityi

Cartilage primordia and cartilage.

Inductioni

Repressed by retinoic acid.

Gene expression databases

BgeeiENSRNOG00000001499
GenevisibleiQ62946 RN

Interactioni

Subunit structurei

Interacts with FASLG.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002050

Structurei

3D structure databases

ProteinModelPortaliQ62946
SMRiQ62946
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 112SH3PROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the MIA/OTOR family.Curated

Keywords - Domaini

SH3 domain, Signal

Phylogenomic databases

eggNOGiENOG410IVZ6 Eukaryota
ENOG411207U LUCA
GeneTreeiENSGT00390000010535
HOGENOMiHOG000063668
HOVERGENiHBG000503
InParanoidiQ62946
KOiK16655
OMAiFIPIRQG
OrthoDBiEOG091G0RVX

Family and domain databases

InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCSPVLLGI VILSVFSGLS RADRAMPKLA DRKLCADEEC SHPISMAVAL
60 70 80 90 100
QDYVAPDCRF LTIYRGQVVY VFSKLKGRGR LFWGGSVQGD YYGDLAAHLG
110 120 130
YFPSSIVRED LTLKPGKVDM KTDEWDFYCQ
Length:130
Mass (Da):14,536
Last modified:February 21, 2001 - v2
Checksum:i5F99149AECF74501
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 47MA → VT in AAC52481 (PubMed:8621736).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51438 mRNA Translation: AAC52481.1
U67884 mRNA Translation: AAB40659.1
RefSeqiNP_110479.1, NM_030852.2
UniGeneiRn.10660

Genome annotation databases

EnsembliENSRNOT00000002050; ENSRNOP00000002050; ENSRNOG00000001499
GeneIDi81510
KEGGirno:81510
UCSCiRGD:620883 rat

Similar proteinsi

Entry informationi

Entry nameiMIA_RAT
AccessioniPrimary (citable) accession number: Q62946
Secondary accession number(s): P97591
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health